Pediatric high-grade glioma: biologically and clinically in need of new thinking.
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Date
2017-02-01ICR Author
Author
Jones, C
Karajannis, MA
Jones, DTW
Kieran, MW
Monje, M
Baker, SJ
Becher, OJ
Cho, Y-J
Gupta, N
Hawkins, C
Hargrave, D
Haas-Kogan, DA
Jabado, N
Li, X-N
Mueller, S
Nicolaides, T
Packer, RJ
Persson, AI
Phillips, JJ
Simonds, EF
Stafford, JM
Tang, Y
Pfister, SM
Weiss, WA
Type
Journal Article
Metadata
Show full item recordAbstract
High-grade gliomas in children are different from those that arise in adults. Recent collaborative molecular analyses of these rare cancers have revealed previously unappreciated connections among chromatin regulation, developmental signaling, and tumorigenesis. As we begin to unravel the unique developmental origins and distinct biological drivers of this heterogeneous group of tumors, clinical trials need to keep pace. It is important to avoid therapeutic strategies developed purely using data obtained from studies on adult glioblastoma. This approach has resulted in repetitive trials and ineffective treatments being applied to these children, with limited improvement in clinical outcome. The authors of this perspective, comprising biology and clinical expertise in the disease, recently convened to discuss the most effective ways to translate the emerging molecular insights into patient benefit. This article reviews our current understanding of pediatric high-grade glioma and suggests approaches for innovative clinical management.
Collections
Subject
Humans
Glioma
Brain Neoplasms
Cell Transformation, Neoplastic
Prognosis
Child
Neoplasm Grading
Research team
Glioma Team
Language
eng
Date accepted
2016-04-14
License start date
2017-02
Citation
Neuro-oncology, 2017, 19 (2), pp. 153 - 161
Publisher
OXFORD UNIV PRESS INC