dc.contributor.author | Geukens, T | |
dc.contributor.author | De Schepper, M | |
dc.contributor.author | Van Den Bogaert, W | |
dc.contributor.author | Van Baelen, K | |
dc.contributor.author | Maetens, M | |
dc.contributor.author | Pabba, A | |
dc.contributor.author | Mahdami, A | |
dc.contributor.author | Leduc, S | |
dc.contributor.author | Isnaldi, E | |
dc.contributor.author | Nguyen, H-L | |
dc.contributor.author | Bachir, I | |
dc.contributor.author | Hajipirloo, M | |
dc.contributor.author | Zels, G | |
dc.contributor.author | Van Cauwenberge, J | |
dc.contributor.author | Borremans, K | |
dc.contributor.author | Vandecaveye, V | |
dc.contributor.author | Weynand, B | |
dc.contributor.author | Vermeulen, P | |
dc.contributor.author | Leucci, E | |
dc.contributor.author | Baietti, MF | |
dc.contributor.author | Sflomos, G | |
dc.contributor.author | Battista, L | |
dc.contributor.author | Brisken, C | |
dc.contributor.author | Derksen, PWB | |
dc.contributor.author | Koorman, T | |
dc.contributor.author | Visser, D | |
dc.contributor.author | Scheele, CLGJ | |
dc.contributor.author | Thommen, DS | |
dc.contributor.author | Hatse, S | |
dc.contributor.author | Fendt, S-M | |
dc.contributor.author | Vanderheyden, E | |
dc.contributor.author | Van Brussel, T | |
dc.contributor.author | Schepers, R | |
dc.contributor.author | Boeckx, B | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Marano, G | |
dc.contributor.author | Biganzoli, E | |
dc.contributor.author | Smeets, A | |
dc.contributor.author | Nevelsteen, I | |
dc.contributor.author | Punie, K | |
dc.contributor.author | Neven, P | |
dc.contributor.author | Wildiers, H | |
dc.contributor.author | Richard, F | |
dc.contributor.author | Floris, G | |
dc.contributor.author | Desmedt, C | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2024-07-10T14:46:17Z | |
dc.date.available | 2024-07-10T14:46:17Z | |
dc.date.issued | 2024-04-24 | |
dc.identifier | ARTN 31 | |
dc.identifier | 10.1038/s41523-024-00637-3 | |
dc.identifier.citation | npj Breast Cancer, 2024, 10 (1), pp. 31 - | en_US |
dc.identifier.issn | 2374-4677 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6308 | |
dc.identifier.eissn | 2374-4677 | |
dc.identifier.eissn | 2374-4677 | |
dc.identifier.doi | 10.1038/s41523-024-00637-3 | |
dc.identifier.doi | 10.1038/s41523-024-00637-3 | |
dc.description.abstract | Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8 liquids per patient from its first 20 patients. In a dedicated experiment, we show the mild impact of increasing time after death on RNA quality, transcriptional profiles and immunohistochemical staining in tumor tissue samples. We show that this impact can be counteracted by organ cooling. We successfully generated ex vivo models from tissue and liquid biopsies from distinct histological subtypes of breast cancer. We anticipate these and future findings of UPTIDER to elucidate mechanisms of disease progression and treatment resistance and to provide tools for the exploration of precision medicine strategies in the metastatic setting. | |
dc.format | Electronic | |
dc.format.extent | 31 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | NATURE PORTFOLIO | en_US |
dc.relation.ispartof | npj Breast Cancer | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Oncology | |
dc.subject | PROGESTERONE-RECEPTOR | |
dc.subject | GENE-EXPRESSION | |
dc.subject | PRIMARY TUMORS | |
dc.subject | COLD ISCHEMIA | |
dc.subject | BREAST | |
dc.subject | HETEROGENEITY | |
dc.subject | PROCUREMENT | |
dc.subject | ESTROGEN | |
dc.subject | MODEL | |
dc.subject | TIME | |
dc.title | Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2024-04-05 | |
dc.date.updated | 2024-07-10T14:45:42Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1038/s41523-024-00637-3 | en_US |
rioxxterms.licenseref.startdate | 2024-04-24 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38658604 | |
pubs.issue | 1 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrine control mechanisms | |
pubs.publication-status | Published online | |
pubs.publisher-url | http://dx.doi.org/10.1038/s41523-024-00637-3 | |
pubs.volume | 10 | |
icr.researchteam | Endocrine control mechans | en_US |
dc.contributor.icrauthor | Brisken, Cathrin | |
icr.provenance | Deposited by Mr Arek Surman on 2024-07-10. Deposit type is initial. No. of files: 1. Files: Rapid autopsies to enhance metastatic research the UPTIDER post-mortem tissue donation program.pdf | |