dc.contributor.author | Xu, Z | |
dc.contributor.author | Davies, ER | |
dc.contributor.author | Yao, L | |
dc.contributor.author | Zhou, Y | |
dc.contributor.author | Li, J | |
dc.contributor.author | Alzetani, A | |
dc.contributor.author | Marshall, BG | |
dc.contributor.author | Hancock, D | |
dc.contributor.author | Wallis, T | |
dc.contributor.author | Downward, J | |
dc.contributor.author | Ewing, RM | |
dc.contributor.author | Davies, DE | |
dc.contributor.author | Jones, MG | |
dc.contributor.author | Wang, Y | |
dc.coverage.spatial | Netherlands | |
dc.date.accessioned | 2024-07-30T14:02:43Z | |
dc.date.available | 2024-07-30T14:02:43Z | |
dc.date.issued | 2024-05-01 | |
dc.identifier | ARTN 101065 | |
dc.identifier | S2352-3042(23)00346-X | |
dc.identifier.citation | Genes and Diseases, 2024, 11 (3), pp. 101065 - | en_US |
dc.identifier.issn | 2352-4820 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/6323 | |
dc.identifier.eissn | 2352-3042 | |
dc.identifier.eissn | 2352-3042 | |
dc.identifier.doi | 10.1016/j.gendis.2023.06.034 | |
dc.identifier.doi | 10.1016/j.gendis.2023.06.034 | |
dc.description.abstract | The factors that determine fibrosis progression or normal tissue repair are largely unknown. We previously demonstrated that autophagy inhibition-mediated epithelial-mesenchymal transition (EMT) in human alveolar epithelial type II (ATII) cells augments local myofibroblast differentiation in pulmonary fibrosis by paracrine signalling. Here, we report that liver kinase B1 (LKB1) inactivation in ATII cells inhibits autophagy and induces EMT as a consequence. In IPF lungs, this is caused by downregulation of CAB39L, a key subunit within the LKB1 complex. 3D co-cultures of ATII cells and MRC5 lung fibroblasts coupled with RNA sequencing (RNA-seq) confirmed that paracrine signalling between LKB1-depleted ATII cells and fibroblasts augmented myofibroblast differentiation. Together these data suggest that reduced autophagy caused by LKB1 inhibition can induce EMT in ATII cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk. | |
dc.format | Print | |
dc.format.extent | 101065 - | |
dc.language | eng | |
dc.language.iso | eng | en_US |
dc.publisher | KEAI PUBLISHING LTD | en_US |
dc.relation.ispartof | Genes and Diseases | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | Genetics & Heredity | |
dc.subject | LKB1 | |
dc.subject | CAB39L | |
dc.subject | EMT | |
dc.subject | Crosstalk | |
dc.subject | Pulmonary fibrosis | |
dc.subject | IDIOPATHIC PULMONARY-FIBROSIS | |
dc.subject | SIGNALING PATHWAY | |
dc.subject | AUTOPHAGY | |
dc.subject | KINASE | |
dc.subject | CANCER | |
dc.title | LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis. | en_US |
dc.type | Journal Article | |
dcterms.dateAccepted | 2023-06-28 | |
dc.date.updated | 2024-07-30T14:01:54Z | |
rioxxterms.version | VoR | en_US |
rioxxterms.versionofrecord | 10.1016/j.gendis.2023.06.034 | en_US |
rioxxterms.licenseref.startdate | 2024-05-01 | |
rioxxterms.type | Journal Article/Review | en_US |
pubs.author-url | https://www.ncbi.nlm.nih.gov/pubmed/38222900 | |
pubs.issue | 3 | |
pubs.organisational-group | ICR | |
pubs.organisational-group | ICR/Primary Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Cancer Biology/Lung Cancer Group | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | ICR/Primary Group/ICR Divisions/Closed research teams/Lung Cancer Group | |
pubs.publication-status | Published | |
pubs.publisher-url | http://dx.doi.org/10.1016/j.gendis.2023.06.034 | |
pubs.volume | 11 | |
icr.researchteam | Lung Cancer Group | en_US |
dc.contributor.icrauthor | Downward, Julian David Harry | |
icr.provenance | Deposited by Mr Arek Surman on 2024-07-30. Deposit type is initial. No. of files: 1. Files: LKB1 depletion-mediated epithelial-mesenchymal transition induces fibroblast activation in lung fibrosis.pdf | |