Browsing Molecular Pathology by author "Greaves, Melvyn"
Now showing items 1-20 of 21
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A causal mechanism for childhood acute lymphoblastic leukaemia.
Greaves, M (NATURE PORTFOLIO, 2018-08-01)In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two discrete steps. First, in utero initiation ... -
A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1.
Vijayakrishnan, J; Kumar, R; Henrion, MYR; Moorman, AV; Rachakonda, PS; et al. (NATURE PUBLISHING GROUP, 2017-03-01)Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype ... -
Can we prevent childhood Leukaemia?
Greaves, M; Cazzaniga, V; Ford, A (SPRINGERNATURE, 2021-05-01) -
Cancer cell transmission via the placenta.
Greaves, M; Hughes, W (OXFORD UNIV PRESS, 2018-01-01)Cancer cells have a parasitic propensity in the primary host but their capacity to transit between individuals is severely restrained by two factors: a lack of a route for viable cell transfer and immune recognition in ... -
Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.
Lote, H; Spiteri, I; Ermini, L; Vatsiou, A; Roy, A; et al. (2017-06)Background Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs. The evolutionary trajectory of cancers can be defined using phylogenetic approaches but ... -
Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.
Lote, H; Spiteri, I; Ermini, L; Vatsiou, A; Roy, A; et al. (OXFORD UNIV PRESS, 2017-02-23)BACKGROUND: Patients often ask oncologists how long a cancer has been present before causing symptoms or spreading to other organs. The evolutionary trajectory of cancers can be defined using phylogenetic approaches but ... -
Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia.
Turati, VA; Guerra-Assunção, JA; Potter, NE; Gupta, R; Ecker, S; et al. (NATURE PORTFOLIO, 2021-07-05)Comparison of intratumor genetic heterogeneity in cancer at diagnosis and relapse suggests that chemotherapy induces bottleneck selection of subclonal genotypes. However, evolutionary events subsequent to chemotherapy could ... -
Classifying the evolutionary and ecological features of neoplasms.
Maley, CC; Aktipis, A; Graham, TA; Sottoriva, A; Boddy, AM; et al. (NATURE PUBLISHING GROUP, 2017-10-01)Neoplasms change over time through a process of cell-level evolution, driven by genetic and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic cell determines which changes provide adaptive ... -
Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients.
Jones, JR; Weinhold, N; Ashby, C; Walker, BA; Wardell, C; et al. (FERRATA STORTI FOUNDATION, 2019-06-30)The emergence of treatment resistant sub-clones is a key feature of relapse in multiple myeloma. Therapeutic attempts to extend remission and prevent relapse include maximizing response and the use of maintenance therapy. ... -
Convergent TP53 loss and evolvability in cancer.
Mansur, MB; Greaves, M (BMC, 2023-09-25)Cancer cell populations evolve by a stepwise process involving natural selection of the fittest variants within a tissue ecosystem context and as modified by therapy. Genomic scrutiny of patient samples reveals an extraordinary ... -
Covert pre-leukaemic clones in healthy co-twins of patients with childhood acute lymphoblastic leukaemia.
Ford, AM; Colman, S; Greaves, M (SPRINGERNATURE, 2023-01-01) -
Genetic and functional diversity of propagating cells in glioblastoma.
Piccirillo, SGM; Colman, S; Potter, NE; van Delft, FW; Lillis, S; et al. (CELL PRESS, 2015-01-13)Glioblastoma (GBM) is a lethal malignancy whose clinical intransigence has been linked to extensive intraclonal genetic and phenotypic diversity and the common emergence of therapeutic resistance. This interpretation ... -
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Vijayakrishnan, J; Studd, J; Broderick, P; Kinnersley, B; Holroyd, A; et al. (NATURE PORTFOLIO, 2018-04-09)Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform ... -
Genomic Classification and Prognosis in Acute Myeloid Leukemia.
Papaemmanuil, E; Gerstung, M; Bullinger, L; Gaidzik, VI; Paschka, P; et al. (MASSACHUSETTS MEDICAL SOC, 2016-06-09)BACKGROUND: Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and ... -
Nothing in cancer makes sense except….
Greaves, M (BMC, 2018-02-21)Paraphrasing Dobzhansky's famous dictum, I discuss how interrogating cancer through the lens of evolution has transformed our understanding of its development, causality and treatment resistance. The emerging picture of ... -
Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster
Cazzaniga, G; Bisanti, L; Randi, G; Deandrea, S; Bungaro, S; et al. (Springer Science and Business Media LLC, 2017-08-01) -
Protracted dormancy of pre-leukemic stem cells.
Ford, AM; Mansur, MB; Furness, CL; van Delft, FW; Okamura, J; et al. (NATURE PUBLISHING GROUP, 2015-11-01)Cancer stem cells can escape therapeutic killing by adopting a quiescent or dormant state. The reversibility of this condition provides the potential for later recurrence or relapse, potentially many years later. We describe ... -
Single cell analysis of clonal architecture in acute myeloid leukaemia.
Potter, N; Miraki-Moud, F; Ermini, L; Titley, I; Vijayaraghavan, G; et al. (NATURE PUBLISHING GROUP, 2019-05-01)We used single cell Q-PCR on a micro-fluidic platform (Fluidigm) to analyse clonal, genetic architecture and phylogeny in acute myeloid leukaemia (AML) using selected mutations. Ten cases of NPM1c mutant AML were screened ... -
The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia.
Mansur, MB; Furness, CL; Nakjang, S; Enshaei, A; Alpar, D; et al. (WILEY, 2021-07-01)BACKGROUND: Treatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T-cell acute lymphoblastic leukemia (T-ALL). Understanding the biology of disease in this ... -
The Interplay of Cesarean-Section Delivery and First-Birth Order as Risk Factors in Acute Lymphoblastic Leukemia.
Pombo-de-Oliveira, MS; EMiLI Study Group,; Petridou, ET; Karalexi, MA; Junqueira, MER; et al. (AMER ASSOC CANCER RESEARCH, 2023-03-06)BACKGROUND: Childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) has been associated with early-life exposures, including birth by cesarean section (C-section), and a deficit of social exposure (first child). ...