Now showing items 273-292 of 690

    • A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1. 

      Vijayakrishnan, J; Kumar, R; Henrion, MYR; Moorman, AV; Rachakonda, PS; Hosen, I; da Silva Filho, MI; Holroyd, A; Dobbins, SE; Koehler, R; Thomsen, H; Irving, JA; Allan, JM; Lightfoot, T; Roman, E; Kinsey, SE; Sheridan, E; Thompson, PD; Hoffmann, P; Nöthen, MM; Heilmann-Heimbach, S; Jöckel, KH; Greaves, M; Harrison, CJ; Bartram, CR; Schrappe, M; Stanulla, M; Hemminki, K; Houlston, RS (2017-03)
      Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype ...
    • Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. 

      Vijayakrishnan, J; Studd, J; Broderick, P; Kinnersley, B; Holroyd, A; Law, PJ; Kumar, R; Allan, JM; Harrison, CJ; Moorman, AV; Vora, A; Roman, E; Rachakonda, S; Kinsey, SE; Sheridan, E; Thompson, PD; Irving, JA; Koehler, R; Hoffmann, P; Nöthen, MM; Heilmann-Heimbach, S; Jöckel, K-H; Easton, DF; Pharaoh, PDP; Dunning, AM; Peto, J; Canzian, F; Swerdlow, A; Eeles, RA; Kote-Jarai, Z; Muir, K; Pashayan, N; PRACTICAL Consortium; Greaves, M; Zimmerman, M; Bartram, CR; Schrappe, M; Stanulla, M; Hemminki, K; Houlston, RS (2018-04-09)
      Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform ...
    • Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma. 

      Sud, A; Thomsen, H; Orlando, G; Försti, A; Law, PJ; Broderick, P; Cooke, R; Hariri, F; Pastinen, T; Easton, DF; Pharoah, PDP; Dunning, AM; Peto, J; Canzian, F; Eeles, R; Kote-Jarai, Z; Muir, K; Pashayan, N; Campa, D; PRACTICAL Consortium; Hoffmann, P; Nöthen, MM; Jöckel, K-H; von Strandmann, EP; Swerdlow, AJ; Engert, A; Orr, N; Hemminki, K; Houlston, RS (2018-11)
      To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL ...
    • Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. 

      Sud, A; Thomsen, H; Law, PJ; Försti, A; Filho, MIDS; Holroyd, A; Broderick, P; Orlando, G; Lenive, O; Wright, L; Cooke, R; Easton, D; Pharoah, P; Dunning, A; Peto, J; Canzian, F; Eeles, R; Kote-Jarai, Z; Muir, K; Pashayan, N; PRACTICAL consortium; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Strandmann, EPV; Lightfoot, T; Kane, E; Roman, E; Lake, A; Montgomery, D; Jarrett, RF; Swerdlow, AJ; Engert, A; Orr, N; Hemminki, K; Houlston, RS (2017-12)
      Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide ...
    • Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. 

      Melin, BS; Barnholtz-Sloan, JS; Wrensch, MR; Johansen, C; Il'yasova, D; Kinnersley, B; Ostrom, QT; Labreche, K; Chen, Y; Armstrong, G; Liu, Y; Eckel-Passow, JE; Decker, PA; Labussière, M; Idbaih, A; Hoang-Xuan, K; Di Stefano, A-L; Mokhtari, K; Delattre, J-Y; Broderick, P; Galan, P; Gousias, K; Schramm, J; Schoemaker, MJ; Fleming, SJ; Herms, S; Heilmann, S; Nöthen, MM; Wichmann, H-E; Schreiber, S; Swerdlow, A; Lathrop, M; Simon, M; Sanson, M; Andersson, U; Rajaraman, P; Chanock, S; Linet, M; Wang, Z; Yeager, M; GliomaScan Consortium; Wiencke, JK; Hansen, H; McCoy, L; Rice, T; Kosel, ML; Sicotte, H; Amos, CI; Bernstein, JL; Davis, F; Lachance, D; Lau, C; Merrell, RT; Shildkraut, J; Ali-Osman, F; Sadetzki, S; Scheurer, M; Shete, S; Lai, RK; Claus, EB; Olson, SH; Jenkins, RB; Houlston, RS; Bondy, ML (2017-05)
      Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two ...
    • Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma. 

      da Silva Filho, MI; Försti, A; Weinhold, N; Meziane, I; Campo, C; Huhn, S; Nickel, J; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Landi, S; Mitchell, JS; Johnson, D; Morgan, GJ; Houlston, R; Goldschmidt, H; Jauch, A; Milani, P; Merlini, G; Rowcieno, D; Hawkins, P; Hegenbart, U; Palladini, G; Wechalekar, A; Schönland, SO; Hemminki, K (2017-08)
      Immunoglobulin light chain (AL) amyloidosis is characterized by tissue deposition of amyloid fibers derived from immunoglobulin light chain. AL amyloidosis and multiple myeloma (MM) originate from monoclonal gammopathy of ...
    • Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells. 

      Pettitt, SJ; Krastev, DB; Pemberton, HN; Fontebasso, Y; Frankum, J; Rehman, FL; Brough, R; Song, F; Bajrami, I; Rafiq, R; Wallberg, F; Kozarewa, I; Fenwick, K; Armisen-Garrido, J; Swain, A; Gulati, A; Campbell, J; Ashworth, A; Lord, CJ (2017-03)
      We describe a screen for cellular response to drugs that makes use of haploid embryonic stem cells. We generated ten libraries of mutants with piggyBac gene trap transposon integrations, totalling approximately 100,000 ...
    • Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress. 

      McDade, SS; Patel, D; Moran, M; Campbell, J; Fenwick, K; Kozarewa, I; Orr, NJ; Lord, CJ; Ashworth, AA; McCance, DJ (2014-06)
      In response to genotoxic stress the TP53 tumour suppressor activates target gene expression to induce cell cycle arrest or apoptosis depending on the extent of DNA damage. These canonical activities can be repressed by ...
    • Genome-wide homozygosity signature and risk of Hodgkin lymphoma. 

      Sud, A; Cooke, R; Swerdlow, AJ; Houlston, RS (2015-09-22)
      Recent studies have reported that regions of homozygosity (ROH) in the genome are detectable in outbred populations and can be associated with an increased risk of malignancy. To examine whether homozygosity is associated ...
    • Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer. 

      Woolston, A; Khan, K; Spain, G; Barber, LJ; Griffiths, B; Gonzalez-Exposito, R; Hornsteiner, L; Punta, M; Patil, Y; Newey, A; Mansukhani, S; Davies, MN; Furness, A; Sclafani, F; Peckitt, C; Jiménez, M; Kouvelakis, K; Ranftl, R; Begum, R; Rana, I; Thomas, J; Bryant, A; Quezada, S; Wotherspoon, A; Khan, N; Fotiadis, N; Marafioti, T; Powles, T; Lise, S; Calvo, F; Guettler, S; von Loga, K; Rao, S; Watkins, D; Starling, N; Chau, I; Sadanandam, A; Cunningham, D; Gerlinger, M (2019-07)
      Despite biomarker stratification, the anti-EGFR antibody cetuximab is only effective against a subgroup of colorectal cancers (CRCs). This genomic and transcriptomic analysis of the cetuximab resistance landscape in 35 RAS ...
    • A genomic atlas of human adrenal and gonad development. 

      Del Valle, I; Buonocore, F; Duncan, AJ; Lin, L; Barenco, M; Parnaik, R; Shah, S; Hubank, M; Gerrelli, D; Achermann, JC (2017-04-07)
      In humans, the adrenal glands and gonads undergo distinct biological events between 6-10 weeks post conception (wpc), such as testis determination, the onset of steroidogenesis and primordial germ cell development. However, ...
    • Genomic Classification and Prognosis in Acute Myeloid Leukemia. 

      Papaemmanuil, E; Gerstung, M; Bullinger, L; Gaidzik, VI; Paschka, P; Roberts, ND; Potter, NE; Heuser, M; Thol, F; Bolli, N; Gundem, G; Van Loo, P; Martincorena, I; Ganly, P; Mudie, L; McLaren, S; O'Meara, S; Raine, K; Jones, DR; Teague, JW; Butler, AP; Greaves, MF; Ganser, A; Döhner, K; Schlenk, RF; Döhner, H; Campbell, PJ (2016-06)
      Recent studies have provided a detailed census of genes that are mutated in acute myeloid leukemia (AML). Our next challenge is to understand how this genetic diversity defines the pathophysiology of AML and informs clinical ...
    • Genomic gain and over expression of CCL2 correlate with vascular invasion in stage I non-seminomatous testicular germ-cell tumours. 

      Gilbert, DC; Chandler, I; Summersgill, B; McIntyre, A; Missiaglia, E; Goddard, NC; Huddart, RA; Shipley, J (2011-08)
      Testicular germ-cell tumours (TGCT) are the most frequent solid tumour to affect young Caucasian adult males and have increased in incidence over recent decades. In clinical stage I non-seminomas, (NSGCT) histological ...
    • Genomic instability and the selection of treatments for cancer. 

      Martin, SA; Hewish, M; Lord, CJ; Ashworth, A (2010-01)
      A critical link exists between DNA mutation and chromosomal rearrangements (genomic instability) and cancer development. This genomic instability can manifest itself as small changes at the nucleotide level or as gross ...
    • Genomic instability and TP53 genomic alterations associate with poor anti-proliferative response and intrinsic resistance to aromatase inhibitor treatment 

      Schuster, E; Gellert, P; Segal, C; Lopez-Knowles, E; Buus, R; Cheang, M; Morden, J; Robertson, J; Bliss, J; Smith, I; Dowsett, M
    • The genomic landscape of plasma cells in systemic light chain amyloidosis. 

      Boyle, EM; Ashby, C; Wardell, CP; Rowczenio, D; Sachchithanantham, S; Wang, Y; Johnson, SK; Bauer, MA; Weinhold, N; Kaiser, MF; Johnson, DC; Jones, JR; Pawlyn, C; Proszek, P; Schinke, C; Facon, T; Dumontet, C; Davies, FE; Morgan, GJ; Walker, BA; Wechalekar, AD (2018-12)
    • The genomic landscape of testicular germ cell tumours: from susceptibility to treatment. 

      Litchfield, K; Levy, M; Huddart, RA; Shipley, J; Turnbull, C (2016-07)
      The genomic landscape of testicular germ cell tumour (TGCT) can be summarized using four overarching hypotheses. Firstly, TGCT risk is dominated by inherited genetic factors, which determine nearly half of all disease risk ...
    • Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia. 

      Speedy, HE; Kinnersley, B; Chubb, D; Broderick, P; Law, PJ; Litchfield, K; Jayne, S; Dyer, MJS; Dearden, C; Follows, GA; Catovsky, D; Houlston, RS (2016-11)
      Chronic lymphocytic leukemia (CLL) can be familial; however, thus far no rare germ line disruptive alleles for CLL have been identified. We performed whole-exome sequencing of 66 CLL families, identifying 4 families where ...
    • The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium. 

      Amirian, ES; Armstrong, GN; Zhou, R; Lau, CC; Claus, EB; Barnholtz-Sloan, JS; Il'yasova, D; Schildkraut, J; Ali-Osman, F; Sadetzki, S; Johansen, C; Houlston, RS; Jenkins, RB; Lachance, D; Olson, SH; Bernstein, JL; Merrell, RT; Wrensch, MR; Davis, FG; Lai, R; Shete, S; Amos, CI; Scheurer, ME; Aldape, K; Alafuzoff, I; Brännström, T; Broholm, H; Collins, P; Giannini, C; Rosenblum, M; Tihan, T; Melin, BS; Bondy, ML (2016-01)
      Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity ...
    • A Global Covariance Descriptor for Nuclear Atypia Scoring in Breast Histopathology Images 

      Khan, AM; Sirinukunwattana, K; Rajpoot, N (IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2015-09)
      Nuclear atypia scoring is a diagnostic measure commonly used to assess tumor grade of various cancers, including breast cancer. It provides a quantitative measure of deviation in visual appearance of cell nuclei from those ...