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Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.
(2017-12-12)
The immunosuppressive protein PD-L1 is upregulated in many cancers and contributes to evasion of the host immune system. The relative importance of the tumor microenvironment and cancer cell-intrinsic signaling in the ...
Signalling pathways implicated in early mammary gland morphogenesis and breast cancer.
(PUBLIC LIBRARY SCIENCE, 2006-08-01)
Specification of mammary epithelial cell fate occurs during embryogenesis as cells aggregate to form the mammary anlage. Within the embryonic mammary bud, a population of epithelial cells exists that will subsequently ...
Pten Regulates Epithelial Cytodifferentiation during Prostate Development.
(PUBLIC LIBRARY SCIENCE, 2015-06-15)
Gene expression and functional studies have indicated that the molecular programmes involved in prostate development are also active in prostate cancer. PTEN has been implicated in human prostate cancer and is frequently ...