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dc.contributor.authorBrewer, HR
dc.contributor.authorJones, ME
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorAshworth, A
dc.contributor.authorSwerdlow, AJ
dc.date.accessioned2017-07-19T14:52:32Z
dc.date.issued2017-08
dc.identifier.citationBreast cancer research and treatment, 2017, 165 (1), pp. 193 - 200
dc.identifier.issn0167-6806
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/714
dc.identifier.eissn1573-7217
dc.identifier.doi10.1007/s10549-017-4325-2
dc.description.abstractPurpose Family history is an important risk factor for breast cancer incidence, but the parameters conventionally used to categorize it are based solely on numbers and/or ages of breast cancer cases in the family and take no account of the size and age-structure of the woman's family.Methods Using data from the Generations Study, a cohort of over 113,000 women from the general UK population, we analyzed breast cancer risk in relation to first-degree family history using a family history score (FHS) that takes account of the expected number of family cases based on the family's age-structure and national cancer incidence rates.Results Breast cancer risk increased significantly (P trend  < 0.0001) with greater FHS. There was a 3.5-fold (95% CI 2.56-4.79) range of risk between the lowest and highest FHS groups, whereas women who had two or more relatives with breast cancer, the strongest conventional familial risk factor, had a 2.5-fold (95% CI 1.83-3.47) increase in risk. Using likelihood ratio tests, the best model for determining breast cancer risk due to family history was that combining FHS and age of relative at diagnosis.Conclusions A family history score based on expected as well as observed breast cancers in a family can give greater risk discrimination on breast cancer incidence than conventional parameters based solely on cases in affected relatives. Our modeling suggests that a yet stronger predictor of risk might be a combination of this score and age at diagnosis in relatives.
dc.formatPrint-Electronic
dc.format.extent193 - 200
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectMedical History Taking
dc.subjectIncidence
dc.subjectLikelihood Functions
dc.subjectProportional Hazards Models
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectProspective Studies
dc.subjectPedigree
dc.subjectFamily Characteristics
dc.subjectAge Factors
dc.subjectHeredity
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectYoung Adult
dc.subjectUnited Kingdom
dc.titleFamily history and risk of breast cancer: an analysis accounting for family structure.
dc.typeJournal Article
dcterms.dateAccepted2017-05-29
rioxxterms.versionofrecord10.1007/s10549-017-4325-2
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBreast cancer research and treatment
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume165
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorBrewer, Hannahen
dc.contributor.icrauthorJones, Michaelen
dc.contributor.icrauthorSchoemaker, Minouken
dc.contributor.icrauthorSwerdlow, Anthonyen


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