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dc.contributor.authorMelin, BS
dc.contributor.authorBarnholtz-Sloan, JS
dc.contributor.authorWrensch, MR
dc.contributor.authorJohansen, C
dc.contributor.authorIl'yasova, D
dc.contributor.authorKinnersley, B
dc.contributor.authorOstrom, QT
dc.contributor.authorLabreche, K
dc.contributor.authorChen, Y
dc.contributor.authorArmstrong, G
dc.contributor.authorLiu, Y
dc.contributor.authorEckel-Passow, JE
dc.contributor.authorDecker, PA
dc.contributor.authorLabussière, M
dc.contributor.authorIdbaih, A
dc.contributor.authorHoang-Xuan, K
dc.contributor.authorDi Stefano, A-L
dc.contributor.authorMokhtari, K
dc.contributor.authorDelattre, J-Y
dc.contributor.authorBroderick, P
dc.contributor.authorGalan, P
dc.contributor.authorGousias, K
dc.contributor.authorSchramm, J
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorFleming, SJ
dc.contributor.authorHerms, S
dc.contributor.authorHeilmann, S
dc.contributor.authorNöthen, MM
dc.contributor.authorWichmann, H-E
dc.contributor.authorSchreiber, S
dc.contributor.authorSwerdlow, A
dc.contributor.authorLathrop, M
dc.contributor.authorSimon, M
dc.contributor.authorSanson, M
dc.contributor.authorAndersson, U
dc.contributor.authorRajaraman, P
dc.contributor.authorChanock, S
dc.contributor.authorLinet, M
dc.contributor.authorWang, Z
dc.contributor.authorYeager, M
dc.contributor.authorGliomaScan Consortium
dc.contributor.authorWiencke, JK
dc.contributor.authorHansen, H
dc.contributor.authorMcCoy, L
dc.contributor.authorRice, T
dc.contributor.authorKosel, ML
dc.contributor.authorSicotte, H
dc.contributor.authorAmos, CI
dc.contributor.authorBernstein, JL
dc.contributor.authorDavis, F
dc.contributor.authorLachance, D
dc.contributor.authorLau, C
dc.contributor.authorMerrell, RT
dc.contributor.authorShildkraut, J
dc.contributor.authorAli-Osman, F
dc.contributor.authorSadetzki, S
dc.contributor.authorScheurer, M
dc.contributor.authorShete, S
dc.contributor.authorLai, RK
dc.contributor.authorClaus, EB
dc.contributor.authorOlson, SH
dc.contributor.authorJenkins, RB
dc.contributor.authorHoulston, RS
dc.contributor.authorBondy, ML
dc.date.accessioned2017-08-18T10:30:58Z
dc.date.issued2017-05
dc.identifier.citationNature genetics, 2017, 49 (5), pp. 789 - 794
dc.identifier.issn1061-4036
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/787
dc.identifier.eissn1546-1718
dc.identifier.doi10.1038/ng.3823
dc.description.abstractGenome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10 -9 , odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10 -10 , OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10 -8 , OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10 -11 , OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10 -10 , OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10 -9 , OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10 -10 , OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10 -10 , OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10 -9 , OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10 -8 , OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10 -10 , OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10 -11 , OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10 -9 , OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.
dc.formatPrint-Electronic
dc.format.extent789 - 794
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectGliomaScan Consortium
dc.subjectHumans
dc.subjectGlioma
dc.subjectGlioblastoma
dc.subjectBrain Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectGenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlleles
dc.subjectQuantitative Trait Loci
dc.subjectMeta-Analysis as Topic
dc.subjectGenome-Wide Association Study
dc.titleGenome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
dc.typeJournal Article
dcterms.dateAccepted2017-03-01
rioxxterms.versionofrecord10.1038/ng.3823
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature genetics
pubs.issue5
pubs.notes12 months
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume49
pubs.embargo.terms12 months
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamCancer Genomicsen_US
dc.contributor.icrauthorKinnersley, Benjaminen
dc.contributor.icrauthorSchoemaker, Minouken
dc.contributor.icrauthorBroderick, Peteren
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorHoulston, Richarden


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