dc.contributor.author | Melin, BS | |
dc.contributor.author | Barnholtz-Sloan, JS | |
dc.contributor.author | Wrensch, MR | |
dc.contributor.author | Johansen, C | |
dc.contributor.author | Il'yasova, D | |
dc.contributor.author | Kinnersley, B | |
dc.contributor.author | Ostrom, QT | |
dc.contributor.author | Labreche, K | |
dc.contributor.author | Chen, Y | |
dc.contributor.author | Armstrong, G | |
dc.contributor.author | Liu, Y | |
dc.contributor.author | Eckel-Passow, JE | |
dc.contributor.author | Decker, PA | |
dc.contributor.author | Labussière, M | |
dc.contributor.author | Idbaih, A | |
dc.contributor.author | Hoang-Xuan, K | |
dc.contributor.author | Di Stefano, A-L | |
dc.contributor.author | Mokhtari, K | |
dc.contributor.author | Delattre, J-Y | |
dc.contributor.author | Broderick, P | |
dc.contributor.author | Galan, P | |
dc.contributor.author | Gousias, K | |
dc.contributor.author | Schramm, J | |
dc.contributor.author | Schoemaker, MJ | |
dc.contributor.author | Fleming, SJ | |
dc.contributor.author | Herms, S | |
dc.contributor.author | Heilmann, S | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | Wichmann, H-E | |
dc.contributor.author | Schreiber, S | |
dc.contributor.author | Swerdlow, A | |
dc.contributor.author | Lathrop, M | |
dc.contributor.author | Simon, M | |
dc.contributor.author | Sanson, M | |
dc.contributor.author | Andersson, U | |
dc.contributor.author | Rajaraman, P | |
dc.contributor.author | Chanock, S | |
dc.contributor.author | Linet, M | |
dc.contributor.author | Wang, Z | |
dc.contributor.author | Yeager, M | |
dc.contributor.author | GliomaScan Consortium, | |
dc.contributor.author | Wiencke, JK | |
dc.contributor.author | Hansen, H | |
dc.contributor.author | McCoy, L | |
dc.contributor.author | Rice, T | |
dc.contributor.author | Kosel, ML | |
dc.contributor.author | Sicotte, H | |
dc.contributor.author | Amos, CI | |
dc.contributor.author | Bernstein, JL | |
dc.contributor.author | Davis, F | |
dc.contributor.author | Lachance, D | |
dc.contributor.author | Lau, C | |
dc.contributor.author | Merrell, RT | |
dc.contributor.author | Shildkraut, J | |
dc.contributor.author | Ali-Osman, F | |
dc.contributor.author | Sadetzki, S | |
dc.contributor.author | Scheurer, M | |
dc.contributor.author | Shete, S | |
dc.contributor.author | Lai, RK | |
dc.contributor.author | Claus, EB | |
dc.contributor.author | Olson, SH | |
dc.contributor.author | Jenkins, RB | |
dc.contributor.author | Houlston, RS | |
dc.contributor.author | Bondy, ML | |
dc.date.accessioned | 2017-08-18T10:30:58Z | |
dc.date.issued | 2017-05-01 | |
dc.identifier.citation | Nature genetics, 2017, 49 (5), pp. 789 - 794 | |
dc.identifier.issn | 1061-4036 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/787 | |
dc.identifier.eissn | 1546-1718 | |
dc.identifier.doi | 10.1038/ng.3823 | |
dc.description.abstract | Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10-9, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10-10, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10-8, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10-11, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10-10, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10-9, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10-10, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10-10, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10-9, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10-8, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10-10, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10-11, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10-9, OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology. | |
dc.format | Print-Electronic | |
dc.format.extent | 789 - 794 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
dc.subject | GliomaScan Consortium | |
dc.subject | Humans | |
dc.subject | Glioma | |
dc.subject | Glioblastoma | |
dc.subject | Brain Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Gene Expression Regulation, Neoplastic | |
dc.subject | Genotype | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Alleles | |
dc.subject | Quantitative Trait Loci | |
dc.subject | Meta-Analysis as Topic | |
dc.subject | Genome-Wide Association Study | |
dc.title | Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-03-01 | |
rioxxterms.versionofrecord | 10.1038/ng.3823 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-05 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature genetics | |
pubs.issue | 5 | |
pubs.notes | 12 months | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.publication-status | Published | |
pubs.volume | 49 | |
pubs.embargo.terms | 12 months | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Cancer Genomics | |
dc.contributor.icrauthor | Kinnersley, Benjamin | |
dc.contributor.icrauthor | Broderick, Peter | |
dc.contributor.icrauthor | Schoemaker, Minouk | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Houlston, Richard | |