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dc.contributor.authorMelin, BSen_US
dc.contributor.authorBarnholtz-Sloan, JSen_US
dc.contributor.authorWrensch, MRen_US
dc.contributor.authorJohansen, Cen_US
dc.contributor.authorIl'yasova, Den_US
dc.contributor.authorKinnersley, Ben_US
dc.contributor.authorOstrom, QTen_US
dc.contributor.authorLabreche, Ken_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorArmstrong, Gen_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorEckel-Passow, JEen_US
dc.contributor.authorDecker, PAen_US
dc.contributor.authorLabussière, Men_US
dc.contributor.authorIdbaih, Aen_US
dc.contributor.authorHoang-Xuan, Ken_US
dc.contributor.authorDi Stefano, A-Len_US
dc.contributor.authorMokhtari, Ken_US
dc.contributor.authorDelattre, J-Yen_US
dc.contributor.authorBroderick, Pen_US
dc.contributor.authorGalan, Pen_US
dc.contributor.authorGousias, Ken_US
dc.contributor.authorSchramm, Jen_US
dc.contributor.authorSchoemaker, MJen_US
dc.contributor.authorFleming, SJen_US
dc.contributor.authorHerms, Sen_US
dc.contributor.authorHeilmann, Sen_US
dc.contributor.authorNöthen, MMen_US
dc.contributor.authorWichmann, H-Een_US
dc.contributor.authorSchreiber, Sen_US
dc.contributor.authorSwerdlow, Aen_US
dc.contributor.authorLathrop, Men_US
dc.contributor.authorSimon, Men_US
dc.contributor.authorSanson, Men_US
dc.contributor.authorAndersson, Uen_US
dc.contributor.authorRajaraman, Pen_US
dc.contributor.authorChanock, Sen_US
dc.contributor.authorLinet, Men_US
dc.contributor.authorWang, Zen_US
dc.contributor.authorYeager, Men_US
dc.contributor.authorGliomaScan Consortiumen_US
dc.contributor.authorWiencke, JKen_US
dc.contributor.authorHansen, Hen_US
dc.contributor.authorMcCoy, Len_US
dc.contributor.authorRice, Ten_US
dc.contributor.authorKosel, MLen_US
dc.contributor.authorSicotte, Hen_US
dc.contributor.authorAmos, CIen_US
dc.contributor.authorBernstein, JLen_US
dc.contributor.authorDavis, Fen_US
dc.contributor.authorLachance, Den_US
dc.contributor.authorLau, Cen_US
dc.contributor.authorMerrell, RTen_US
dc.contributor.authorShildkraut, Jen_US
dc.contributor.authorAli-Osman, Fen_US
dc.contributor.authorSadetzki, Sen_US
dc.contributor.authorScheurer, Men_US
dc.contributor.authorShete, Sen_US
dc.contributor.authorLai, RKen_US
dc.contributor.authorClaus, EBen_US
dc.contributor.authorOlson, SHen_US
dc.contributor.authorJenkins, RBen_US
dc.contributor.authorHoulston, RSen_US
dc.contributor.authorBondy, MLen_US
dc.date.accessioned2017-08-18T10:30:58Z
dc.date.issued2017-05en_US
dc.identifier.citationNature genetics, 2017, 49 (5), pp. 789 - 794en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/787
dc.identifier.eissn1546-1718en_US
dc.identifier.doi10.1038/ng.3823en_US
dc.description.abstractGenome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,496 cases and 18,190 controls. We identified five new loci for glioblastoma (GBM) at 1p31.3 (rs12752552; P = 2.04 × 10<sup>-9</sup>, odds ratio (OR) = 1.22), 11q14.1 (rs11233250; P = 9.95 × 10<sup>-10</sup>, OR = 1.24), 16p13.3 (rs2562152; P = 1.93 × 10<sup>-8</sup>, OR = 1.21), 16q12.1 (rs10852606; P = 1.29 × 10<sup>-11</sup>, OR = 1.18) and 22q13.1 (rs2235573; P = 1.76 × 10<sup>-10</sup>, OR = 1.15), as well as eight loci for non-GBM tumors at 1q32.1 (rs4252707; P = 3.34 × 10<sup>-9</sup>, OR = 1.19), 1q44 (rs12076373; P = 2.63 × 10<sup>-10</sup>, OR = 1.23), 2q33.3 (rs7572263; P = 2.18 × 10<sup>-10</sup>, OR = 1.20), 3p14.1 (rs11706832; P = 7.66 × 10<sup>-9</sup>, OR = 1.15), 10q24.33 (rs11598018; P = 3.39 × 10<sup>-8</sup>, OR = 1.14), 11q21 (rs7107785; P = 3.87 × 10<sup>-10</sup>, OR = 1.16), 14q12 (rs10131032; P = 5.07 × 10<sup>-11</sup>, OR = 1.33) and 16p13.3 (rs3751667; P = 2.61 × 10<sup>-9</sup>, OR = 1.18). These data substantiate that genetic susceptibility to GBM and non-GBM tumors are highly distinct, which likely reflects different etiology.en_US
dc.formatPrint-Electronicen_US
dc.format.extent789 - 794en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectGliomaScan Consortiumen_US
dc.subjectHumansen_US
dc.subjectGliomaen_US
dc.subjectGlioblastomaen_US
dc.subjectBrain Neoplasmsen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectGene Expression Regulation, Neoplasticen_US
dc.subjectGenotypeen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectAllelesen_US
dc.subjectQuantitative Trait Locien_US
dc.subjectMeta-Analysis as Topicen_US
dc.subjectGenome-Wide Association Studyen_US
dc.titleGenome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-03-01en_US
rioxxterms.versionofrecord10.1038/ng.3823en_US
rioxxterms.licenseref.startdate2017-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNature geneticsen_US
pubs.issue5en_US
pubs.notes12 monthsen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublisheden_US
pubs.volume49en_US
pubs.embargo.terms12 monthsen_US
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamCancer Genomicsen_US
dc.contributor.icrauthorKinnersley, Benjaminen_US
dc.contributor.icrauthorSchoemaker, Minouken_US
dc.contributor.icrauthorBroderick, Peteren_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorHoulston, Richarden_US


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