Browsing Radiotherapy and Imaging by author "Eeles, Rosalind"
Now showing items 1-20 of 148
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A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
Scarbrough, PM; Weber, RP; Iversen, ES; Brhane, Y; Amos, CI; et al. (AMER ASSOC CANCER RESEARCH, 2016-01-01)BACKGROUND: DNA damage is an established mediator of carcinogenesis, although genome-wide association studies (GWAS) have identified few significant loci. This cross-cancer site, pooled analysis was performed to increase ... -
A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data.
Huynh-Le, M-P; Fan, CC; Karunamuni, R; Walsh, EI; Turner, EL; et al. (AMER ASSOC CANCER RESEARCH, 2020-09-01)BACKGROUND: A polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. ... -
A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.
Marzec, J; Mao, X; Li, M; Wang, M; Feng, N; et al. (IMPACT JOURNALS LLC, 2016-04-19)Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated ... -
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Scott, RA; Freitag, DF; Li, L; Chu, AY; Surendran, P; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2016-06-01)Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ... -
A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study.
Bancroft, EK; Page, EC; Brook, MN; Thomas, S; Taylor, N; et al. (ELSEVIER SCIENCE INC, 2021-10-19)BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and ... -
A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry.
Darst, BF; Hughley, R; Pfennig, A; Hazra, U; Fan, C; et al. (ELSEVIER, 2022-05-01)A rare African ancestry-specific germline deletion variant in HOXB13 (X285K, rs77179853) was recently reported in Martinican men with early-onset prostate cancer. Given the role of HOXB13 germline variation in prostate ... -
A Review of Prostate Cancer Genome-Wide Association Studies (GWAS).
Benafif, S; Kote-Jarai, Z; Eeles, RA; PRACTICAL Consortium, (AMER ASSOC CANCER RESEARCH, 2018-08-01)Prostate cancer is the most common cancer in men in Europe and the United States. The genetic heritability of prostate cancer is contributed to by both rarely occurring genetic variants with higher penetrance and moderate ... -
A risk prediction algorithm based on family history and common genetic variants: application to prostate cancer with potential clinical impact.
Macinnis, RJ; Antoniou, AC; Eeles, RA; Severi, G; Al Olama, AA; et al. (WILEY, 2011-07-18)Genome wide association studies have identified several single nucleotide polymorphisms (SNPs) that are independently associated with small increments in risk of prostate cancer, opening up the possibility for using such ... -
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer.
Karunamuni, RA; Huynh-Le, M-P; Fan, CC; Thompson, W; Eeles, RA; et al. (SPRINGERNATURE, 2021-01-08)BACKGROUND: Polygenic hazard scores (PHS) can identify individuals with increased risk of prostate cancer. We estimated the benefit of additional SNPs on performance of a previously validated PHS (PHS46). MATERIALS AND ... -
Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study.
Brunner, C; Davies, NM; Martin, RM; Eeles, R; Easton, D; et al. (WILEY, 2017-01-01)Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies. The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially ... -
Alcohol Intake and Alcohol-SNP Interactions Associated with Prostate Cancer Aggressiveness.
Lin, H-Y; Wang, X; Tseng, T-S; Kao, Y-H; Fang, Z; et al. (MDPI, 2021-02-02)Excessive alcohol intake is a well-known modifiable risk factor for many cancers. It is still unclear whether genetic variants or single nucleotide polymorphisms (SNPs) can modify alcohol intake's impact on prostate cancer ... -
Ambiguity in a masculine world: Being a BRCA1/2 mutation carrier and a man with prostate cancer.
Moynihan, C; Bancroft, EK; Mitra, A; Ardern-Jones, A; Castro, E; et al. (WILEY, 2017-11-01)OBJECTIVE: Increased risk of prostate cancer (PCa) is observed in men with BRCA1/BRCA2 mutations. Sex and gender are key determinants of health and disease although unequal care exists between the sexes. Stereotypical male ... -
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.
Wu, L; Yang, Y; Guo, X; Shu, X-O; Cai, Q; et al. (NATURE PUBLISHING GROUP, 2020-08-06)It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence ... -
Analysis of Over 140,000 European Descendants Identifies Genetically Predicted Blood Protein Biomarkers Associated with Prostate Cancer Risk.
Wu, L; Shu, X; Bao, J; Guo, X; Kote-Jarai, Z; et al. (AMER ASSOC CANCER RESEARCH, 2019-09-15)Several blood protein biomarkers have been associated with prostate cancer risk. However, most studies assessed only a small number of biomarkers and/or included a small sample size. To identify novel protein biomarkers ... -
Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels.
Bonilla, C; Lewis, SJ; Rowlands, M-A; Gaunt, TR; Davey Smith, G; et al. (WILEY, 2016-10-01)Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are ... -
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
Zhang, YD; Hurson, AN; Zhang, H; Choudhury, PP; Easton, DF; et al. (NATURE PORTFOLIO, 2020-07-03)Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of ... -
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Law, PJ; Timofeeva, M; Fernandez-Rozadilla, C; Broderick, P; Studd, J; et al. (NATURE PUBLISHING GROUP, 2019-05-14)Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that ... -
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
Schumacher, FR; Al Olama, AA; Berndt, SI; Benlloch, S; Ahmed, M; et al. (NATURE PORTFOLIO, 2018-07-01)Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 ... -
Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses.
Khankari, NK; Shu, X-O; Wen, W; Kraft, P; Lindström, S; et al. (PUBLIC LIBRARY SCIENCE, 2016-09-06)BACKGROUND: Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort ... -
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration,; Haycock, PC; Burgess, S; Nounu, A; Zheng, J; et al. (AMER MEDICAL ASSOC, 2017-05-01)IMPORTANCE: The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding ...