Browsing Radiotherapy and Imaging by author "Gothard, Lone"
Now showing items 1-14 of 14
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A randomized control trial evaluating fluorescent ink versus dark ink tattoos for breast radiotherapy.
Landeg, SJ; Kirby, AM; Lee, SF; Bartlett, F; Titmarsh, K; et al. (BRITISH INST RADIOLOGY, 2016-12-01)OBJECTIVE: The purpose of this UK study was to evaluate interfraction reproducibility and body image score when using ultraviolet (UV) tattoos (not visible in ambient lighting) for external references during breast/chest ... -
An ionising radiation-induced specific transcriptional signature of inflammation-associated genes in whole blood from radiotherapy patients: a pilot study.
Cruz-Garcia, L; Badie, C; Anbalagan, S; Moquet, J; Gothard, L; et al. (BMC, 2021-05-03)BACKGROUND: This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to ionising radiation received by radiotherapy patients. METHODS: ... -
Applicability of Scoring Calyculin A-Induced Premature Chromosome Condensation Objects for Dose Assessment Including for Radiotherapy Patients.
Sun, M; Moquet, J; Lloyd, D; Barnard, S; Anbalagan, S; et al. (KARGER, 2023-10-19)As an extension to a previous study, a linear calibration curve covering doses from 0 to 10 Gy was constructed and evaluated in the present study using calyculin A-induced premature chromosome condensation (PCC) by scoring ... -
Correlation between DNA damage responses of skin to a test dose of radiation and late adverse effects of earlier breast radiotherapy.
Somaiah, N; Chua, MLK; Bourne, S; Daley, F; A' Hern, R; et al. (ELSEVIER IRELAND LTD, 2016-05-15)AIM: To correlate residual double strand breaks (DSB) 24h after 4Gy test doses to skin in vivo and to lymphocytes in vitro with adverse effects of earlier breast radiotherapy (RT). PATIENTS AND METHODS: Patients given whole ... -
Correlation between the radiation responses of fibroblasts cultured from individual patients and the risk of late reaction after breast radiotherapy.
Nuta, O; Somaiah, N; Boyle, S; Chua, MLK; Gothard, L; et al. (ELSEVIER IRELAND LTD, 2016-05-01)Late normal tissue toxicity varies widely between patients and limits breast radiotherapy dose. Here we aimed to determine its relationship to DNA damage responses of fibroblast cultures from individual patients. Thirty-five ... -
Dicentric Dose Estimates for Patients Undergoing Radiotherapy in the RTGene Study to Assess Blood Dosimetric Models and the New Bayesian Method for Gradient Exposure.
Moquet, J; Higueras, M; Donovan, E; Boyle, S; Barnard, S; et al. (RADIATION RESEARCH SOC, 2018-09-20)The RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy patient responses to ionizing radiation. In parallel, for validation purposes, this ... -
FDXR is a biomarker of radiation exposure in vivo.
O'Brien, G; Cruz-Garcia, L; Majewski, M; Grepl, J; Abend, M; et al. (NATURE PORTFOLIO, 2018-01-15)Previous investigations in gene expression changes in blood after radiation exposure have highlighted its potential to provide biomarkers of exposure. Here, FDXR transcriptional changes in blood were investigated in humans ... -
Hyperbaric oxygen for patients with chronic bowel dysfunction after pelvic radiotherapy (HOT2): a randomised, double-blind, sham-controlled phase 3 trial.
Glover, M; Smerdon, GR; Andreyev, HJ; Benton, BE; Bothma, P; et al. (ELSEVIER SCIENCE INC, 2016-02-01)BACKGROUND: Hyperbaric oxygen has been used as a therapy for patients experiencing chronic intestinal syndromes after pelvic radiotherapy for decades, yet the evidence to support the use of this therapy is based almost ... -
Influence of Confounding Factors on Radiation Dose Estimation Using In Vivo Validated Transcriptional Biomarkers.
Cruz-Garcia, L; O'Brien, G; Donovan, E; Gothard, L; Boyle, S; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2018-07-01)For triage purposes following a nuclear accident, blood-based gene expression biomarkers can provide rapid dose estimates for a large number of individuals. Ionizing-radiation-responsive genes are regulated through the DNA ... -
Intratumoral Hydrogen Peroxide With Radiation Therapy in Locally Advanced Breast Cancer: Results From a Phase 1 Clinical Trial.
Nimalasena, S; Gothard, L; Anbalagan, S; Allen, S; Sinnett, V; et al. (ELSEVIER SCIENCE INC, 2020-11-15)PURPOSE: Hydrogen peroxide (H2O2) plays a vital role in normal cellular processes but at supraphysiological concentrations causes oxidative stress and cytotoxicity, a property that is potentially exploitable for the treatment ... -
Local control and toxicity after hypofractionated accelerated palliative RT in breast cancer
Webb, K; Gothard, L; Mohammed, K; Kirby, A; Locke, I; et al. (ELSEVIER IRELAND LTD, 2022-05-01) -
Locoregional control and toxicity following high-dose hypofractionated and accelerated palliative radiotherapy regimens in breast cancer.
Webb, K; Gothard, L; Mohammed, K; Kirby, AM; Locke, I; et al. (ELSEVIER SCIENCE LONDON, 2023-09-01)AIMS: For patients with locally advanced primary/recurrent breast cancer, radiotherapy is an effective treatment for locoregional control. 36 Gy in 6 Gy once-weekly fractions is a commonly used schedule, but there are no ... -
Low-cost Kinect Version 2 imaging system for breath hold monitoring and gating: Proof of concept study for breast cancer VMAT radiotherapy
Edmunds, D; Gothard, L; Khabra, K; Kirby, A; Madhale, P; et al. -
Low-cost Kinect Version 2 imaging system for breath hold monitoring and gating: Proof of concept study for breast cancer VMAT radiotherapy.
Edmunds, DM; Gothard, L; Khabra, K; Kirby, A; Madhale, P; et al. (WILEY, 2018-05-01)Voluntary inspiration breath hold (VIBH) for left breast cancer patients has been shown to be a safe and effective method of reducing radiation dose to the heart. Currently, VIBH protocol compliance is monitored visually. ...