Browsing Radiotherapy and Imaging by author "Collins, David"
Now showing items 21-34 of 34
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Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.
Vlachogiannis, G; Hedayat, S; Vatsiou, A; Jamin, Y; Fernández-Mateos, J; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2018-02-23)Patient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has remained unclear. We report on a living biobank of PDOs from ... -
Principal component analysis fosr fast and model-free denoising of multi b-value diffusion-weighted MR images.
Gurney-Champion, OJ; Collins, DJ; Wetscherek, A; Rata, M; Klaassen, R; et al. (IOP PUBLISHING LTD, 2019-04-09)Despite the utility of tumour characterisation using quantitative parameter maps from multi-b-value diffusion-weighted MRI (DWI), clinicians often prefer the use of the image with highest diffusion-weighting (b-value), for ... -
Repeatability of derived parameters from histograms following non-Gaussian diffusion modelling of diffusion-weighted imaging in a paediatric oncological cohort.
Jerome, NP; Miyazaki, K; Collins, DJ; Orton, MR; d'Arcy, JA; et al. (SPRINGER, 2017-01-01)OBJECTIVES: To examine repeatability of parameters derived from non-Gaussian diffusion models in data acquired in children with solid tumours. METHODS: Paediatric patients (<16 years, n = 17) were scanned twice, 24 h apart, ... -
Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI.
Winfield, JM; Orton, MR; Collins, DJ; Ind, TEJ; Attygalle, A; et al. (SPRINGER, 2017-02-01)OBJECTIVES: Assessment of empirical diffusion-weighted MRI (DW-MRI) models in cervical tumours to investigate whether fitted parameters distinguish between types and grades of tumours. METHODS: Forty-two patients (24 ... -
Super-resolution T2-weighted 4D MRI for image guided radiotherapy.
Freedman, JN; Collins, DJ; Gurney-Champion, OJ; McClelland, JR; Nill, S; et al. (ELSEVIER IRELAND LTD, 2018-12-01)BACKGROUND AND PURPOSE: The superior soft-tissue contrast of 4D-T2w MRI motivates its use for delineation in radiotherapy treatment planning. We address current limitations of slice-selective implementations, including ... -
Supervised Machine-Learning Enables Segmentation and Evaluation of Heterogeneous Post-treatment Changes in Multi-Parametric MRI of Soft-Tissue Sarcoma.
Blackledge, MD; Winfield, JM; Miah, A; Strauss, D; Thway, K; et al. (FRONTIERS MEDIA SA, 2019-10-10)Background: Multi-parametric MRI provides non-invasive methods for response assessment of soft-tissue sarcoma (STS) from non-surgical treatments. However, evaluation of MRI parameters over the whole tumor volume may not ... -
Synthetic 4D-CT of the thorax for treatment plan adaptation on MR-guided radiotherapy systems.
Freedman, JN; Bainbridge, HE; Nill, S; Collins, DJ; Kachelrieß, M; et al. (IOP PUBLISHING LTD, 2019-05-23)MR-guided radiotherapy treatment planning utilises the high soft-tissue contrast of MRI to reduce uncertainty in delineation of the target and organs at risk. Replacing 4D-CT with MRI-derived synthetic 4D-CT would support ... -
T2-adjusted computed diffusion-weighted imaging: A novel method to enhance tumour visualisation.
Cheng, L; Blackledge, MD; Collins, DJ; Orton, MR; Jerome, NP; et al. (PERGAMON-ELSEVIER SCIENCE LTD, 2016-12-01)PURPOSE: To introduce T2-adjusted computed DWI (T2-cDWI), a method that provides synthetic images at arbitrary b-values and echo times (TEs) that improve tissue contrast by removing or increasing T2 contrast in diffusion-weighted ... -
T2-Weighted 4D Magnetic Resonance Imaging for Application in Magnetic Resonance-Guided Radiotherapy Treatment Planning.
Freedman, JN; Collins, DJ; Bainbridge, H; Rank, CM; Nill, S; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2017-10-01)OBJECTIVES: The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D ... -
The impact of 2D cine MR imaging parameters on automated tumor and organ localization for MR-guided real-time adaptive radiotherapy.
Menten, MJ; Fast, MF; Wetscherek, A; Rank, CM; Kachelrieß, M; et al. (IOP PUBLISHING LTD, 2018-11-22)2D cine MR imaging may be utilized to monitor rapidly moving tumors and organs-at-risk for real-time adaptive radiotherapy. This study systematically investigates the impact of geometric imaging parameters on the ability ... -
Utility of Multi-Parametric Quantitative Magnetic Resonance Imaging for Characterization and Radiotherapy Response Assessment in Soft-Tissue Sarcomas and Correlation With Histopathology.
Winfield, JM; Miah, AB; Strauss, D; Thway, K; Collins, DJ; et al. (FRONTIERS MEDIA SA, 2019-04-25)Purpose: To evaluate repeatability of quantitative multi-parametric MRI in retroperitoneal sarcomas, assess parameter changes with radiotherapy, and correlate pre-operative values with histopathological findings in the ... -
Value of diffusion-weighted imaging for monitoring tissue change during magnetic resonance-guided high-intensity focused ultrasound therapy in bone applications: an ex-vivo study.
Giles, SL; Winfield, JM; Collins, DJ; Rivens, I; Civale, J; et al. (SPRINGERNATURE, 2018-05-10)BACKGROUND: Magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) can palliate metastatic bone pain by periosteal neurolysis. We investigated the value of diffusion-weighted imaging (DWI) for monitoring ... -
Volume of Bone Metastasis Assessed with Whole-Body Diffusion-weighted Imaging Is Associated with Overall Survival in Metastatic Castration-resistant Prostate Cancer.
Perez-Lopez, R; Lorente, D; Blackledge, MD; Collins, DJ; Mateo, J; et al. (RADIOLOGICAL SOC NORTH AMERICA, 2016-07-01)Purpose To determine the correlation between the volume of bone metastasis as assessed with diffusion-weighted (DW) imaging and established prognostic factors in metastatic castration-resistant prostate cancer (mCRPC) and ... -
Whole-body diffusion-weighted MR imaging for assessment of treatment response in myeloma.
Giles, SL; Messiou, C; Collins, DJ; Morgan, VA; Simpkin, CJ; et al. (RADIOLOGICAL SOC NORTH AMERICA, 2014-06-01)PURPOSE: To determine the feasibility of whole-body diffusion-weighted (DW) magnetic resonance (MR) imaging for assessment of treatment response in myeloma. MATERIALS AND METHODS: This prospective single-institution study ...