Browsing Radiotherapy and Imaging by author "Harrington, Kevin"
Now showing items 61-80 of 158
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Immunological impact of cell death signaling driven by radiation on the tumor microenvironment.
Rodriguez-Ruiz, ME; Vitale, I; Harrington, KJ; Melero, I; Galluzzi, L (NATURE PORTFOLIO, 2020-02-01)Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological ... -
Immunomodulatory activity of IR700-labelled affibody targeting HER2.
Mączyńska, J; Da Pieve, C; Burley, TA; Raes, F; Shah, A; et al. (SPRINGERNATURE, 2020-10-20)There is an urgent need to develop therapeutic approaches that can increase the response rate to immuno-oncology agents. Photoimmunotherapy has recently been shown to generate anti-tumour immunological responses by releasing ... -
Impact of antibiotic use during curative treatment of locally advanced head and neck cancers with chemotherapy and radiotherapy.
Nenclares, P; Bhide, SA; Sandoval-Insausti, H; Pialat, P; Gunn, L; et al. (ELSEVIER SCI LTD, 2020-05-01)BACKGROUND: Pre-clinical evidence suggests reduced efficacy of anticancer treatment in patients exposed to broad-spectrum antibiotics. It is hypothesised that this phenomenon may be explained by the effects of antibiotics ... -
Incorporating spatial dose metrics in machine learning-based normal tissue complication probability (NTCP) models of severe acute dysphagia resulting from head and neck radiotherapy.
Dean, J; Wong, K; Gay, H; Welsh, L; Jones, A-B; et al. (ELSEVIER IRELAND LTD, 2018-01-01)Severe acute dysphagia commonly results from head and neck radiotherapy (RT). A model enabling prediction of severity of acute dysphagia for individual patients could guide clinical decision-making. Statistical associations ... -
Induction Chemotherapy Followed by Chemo-intensity-modulated Radiotherapy for Locally Advanced Nasopharyngeal Cancer.
Miah, AB; Bhide, SA; Del Rosario, L; Matthews, J; Nicol, R; et al. (ELSEVIER SCIENCE LONDON, 2016-08-01)AIMS: To determine the toxicity and tumour control rates after chemo-intensity-modulated radiotherapy (chemo-IMRT) for locally advanced nasopharyngeal cancers (LA-NPC). MATERIALS AND METHODS: Patients with LA-NPC were ... -
Inflammatory microenvironment remodelling by tumour cells after radiotherapy.
McLaughlin, M; Patin, EC; Pedersen, M; Wilkins, A; Dillon, MT; et al. (NATURE PORTFOLIO, 2020-04-01)The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think about cancer treatment. Even so, for most types of cancer, only a minority of patients currently benefit from ICI therapies. Intrinsic ... -
Inhibition of HOX/PBX dimer formation leads to necroptosis in acute myeloid leukemia cells.
Alharbi, RA; Pandha, HS; Simpson, GR; Pettengell, R; Poterlowicz, K; et al. (IMPACT JOURNALS LLC, 2017-10-27)The HOX genes encode a family of transcription factors that have key roles in both development and malignancy. Disrupting the interaction between HOX proteins and their binding partner, PBX, has been shown to cause apoptotic ... -
Intensity modulated radiotherapy in locally advanced thyroid cancer: Outcomes of a sequential phase I dose-escalation study.
Rooney, KP; Miah, AB; Bhide, SA; Guerrero-Urbano, MT; Sharabiani, MT; et al. (ELSEVIER IRELAND LTD, 2018-04-01)BACKGROUND AND PURPOSE: To determine the safety and tolerability of dose-escalation using modestly accelerated IMRT in high-risk locally advanced thyroid cancer requiring post-operative radiotherapy, and to report preliminary ... -
International Guideline on Dose Prioritization and Acceptance Criteria in Radiation Therapy Planning for Nasopharyngeal Carcinoma.
Lee, AW; Ng, WT; Pan, JJ; Chiang, C-L; Poh, SS; et al.Purpose The treatment of nasopharyngeal carcinoma requires high radiation doses. The balance of the risks of local recurrence owing to inadequate tumor coverage versus the potential damage to the adjacent organs at risk ... -
International Recommendations on Reirradiation by Intensity Modulated Radiation Therapy for Locally Recurrent Nasopharyngeal Carcinoma.
Ng, WT; Soong, YL; Ahn, YC; AlHussain, H; Choi, HCW; et al. (ELSEVIER SCIENCE INC, 2021-07-01)PURPOSE: Reirradiation for locally recurrent nasopharyngeal carcinoma (NPC) is challenging because prior radiation dose delivered in the first course is often close to the tolerance limit of surrounding normal structures. ... -
Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade.
Samson, A; Scott, KJ; Taggart, D; West, EJ; Wilson, E; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2018-01-03)Immune checkpoint inhibitors, including those targeting programmed cell death protein 1 (PD-1), are reshaping cancer therapeutic strategies. Evidence suggests, however, that tumor response and patient survival are determined ... -
Introducing the Cancer Research UK Advanced Radiotherapy Technologies Network (ART-NET).
Harrington, K; Hall, E; Hawkins, M; Henry, A; MacKay, R; et al. (2017-11) -
Isolated limb perfusion with biochemotherapy and oncolytic virotherapy combines with radiotherapy and surgery to overcome treatment resistance in an animal model of extremity soft tissue sarcoma.
Wilkinson, MJ; Smith, HG; Pencavel, TD; Mansfield, DC; Kyula-Currie, J; et al. (WILEY, 2016-09-15)The management of locally advanced or recurrent extremity sarcoma often necessitates multimodal therapy to preserve a limb, of which isolated limb perfusion (ILP) is a key component. However, with standard chemotherapeutic ... -
Laryngeal cancer: United Kingdom National Multidisciplinary guidelines.
Jones, TM; De, M; Foran, B; Harrington, K; Mortimore, S (CAMBRIDGE UNIV PRESS, 2016-05-01)This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. Significantly new data have been published on laryngeal cancer management since the ... -
Long-term Outcomes with Nivolumab as First-line Treatment in Recurrent or Metastatic Head and Neck Cancer: Subgroup Analysis of CheckMate 141.
Gillison, ML; Blumenschein, G; Fayette, J; Guigay, J; Colevas, AD; et al. (OXFORD UNIV PRESS, 2022-03-04)In the randomized, phase 3 CheckMate 141 trial, nivolumab significantly improved overall survival (OS) versus investigator's choice (IC) of chemotherapy at primary analysis among 361 patients with recurrent or metastatic ... -
Looking a Gift Horse in the Mouth: Observations on NHS England's Interim Guidance on Pembrolizumab in Head and Neck Squamous Cell Cancer.
Harrington, KJ; Bhide, SA; Forster, MD; Good, JS; Gunn, L; et al. (2020-08) -
Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial.
Bahig, H; Yuan, Y; Mohamed, ASR; Brock, KK; Ng, SP; et al. (ELSEVIER IRELAND LTD, 2018-11-01)BACKGROUND: Current standard radiotherapy for oropharynx cancer (OPC) is associated with high rates of severe toxicities, shown to adversely impact patients' quality of life. Given excellent outcomes of human papilloma ... -
MRI-based Assessment of 3D Intrafractional Motion of Head and Neck Cancer for Radiation Therapy.
Gurney-Champion, OJ; McQuaid, D; Dunlop, A; Wong, KH; Welsh, LC; et al. (ELSEVIER SCIENCE INC, 2018-02-01)PURPOSE: To determine the 3-dimensional (3D) intrafractional motion of head and neck squamous cell carcinoma (HNSCC). METHODS AND MATERIALS: Dynamic contrast-enhanced magnetic resonance images from 56 patients with HNSCC ... -
Near-infrared photoimmunotherapy targeting EGFR-Shedding new light on glioblastoma treatment.
Burley, TA; Mączyńska, J; Shah, A; Szopa, W; Harrington, KJ; et al. (WILEY, 2018-06-01)Glioblastomas (GBMs) are high-grade brain tumors, differentially driven by alterations (amplification, deletion or missense mutations) in the epidermal growth factor receptor (EGFR), that carry a poor prognosis of just ... -
Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients.
Samson, A; West, EJ; Carmichael, J; Scott, KJ; Turnbull, S; et al. (AMER ASSOC CANCER RESEARCH, 2022-06-03)Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research. Pexa-Vec (Pexastimogene Devacirepvec; JX-594, TG6006) is a principally ...