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Immunological impact of cell death signaling driven by radiation on the tumor microenvironment.

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ICR Author
Harrington, Kevin
Author
Rodriguez-Ruiz, ME
Vitale, I
Harrington, KJ
Melero, I
Galluzzi, L
Type
Journal Article
Metadata
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Abstract
Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via multiple, non-redundant mechanisms. Such mechanisms include the selective elimination of particularly radiosensitive cell types and consequent loss of specific cellular functions, the local release of cytokines and danger signals by dying radiosensitive cells, and altered cytokine secretion by surviving radioresistant cells. Altogether, these processes create chemotactic and immunomodulatory cues for incoming and resident immune cells. Here we discuss how cytoprotective and cytotoxic signaling modules activated by radiation in specific cell populations reshape the immunological tumor microenvironment.
URI
https://repository.icr.ac.uk/handle/internal/4444
DOI
https://doi.org/10.1038/s41590-019-0561-4
Collections
  • Cancer Biology
  • Radiotherapy and Imaging
Subject
Animals
Humans
Signal Transduction
Cell Death
Tumor Microenvironment
Research team
Targeted Therapy
Targeted Therapy
Language
eng
Date accepted
2019-11-14
Citation
Nature immunology, 2020, 21 (2), pp. 120 - 134

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