Now showing items 686-705 of 1086

    • p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance. 

      Yogev, O; Barker, K; Sikka, A; Almeida, GS; Hallsworth, A; Smith, LM; Jamin, Y; Ruddle, R; Koers, A; Webber, HT; Raynaud, FI; Popov, S; Jones, C; Petrie, K; Robinson, SP; Keun, HC; Chesler, L (2016-05)
      Neuroblastoma is the most common childhood extracranial solid tumor. In high-risk cases, many of which are characterized by amplification of MYCN, outcome remains poor. Mutations in the p53 (TP53) tumor suppressor are rare ...
    • PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. 

      Southey, MC; Goldgar, DE; Winqvist, R; Pylkäs, K; Couch, F; Tischkowitz, M; Foulkes, WD; Dennis, J; Michailidou, K; van Rensburg, EJ; Heikkinen, T; Nevanlinna, H; Hopper, JL; Dörk, T; Claes, KB; Reis-Filho, J; Teo, ZL; Radice, P; Catucci, I; Peterlongo, P; Tsimiklis, H; Odefrey, FA; Dowty, JG; Schmidt, MK; Broeks, A; Hogervorst, FB; Verhoef, S; Carpenter, J; Clarke, C; Scott, RJ; Fasching, PA; Haeberle, L; Ekici, AB; Beckmann, MW; Peto, J; Dos-Santos-Silva, I; Fletcher, O; Johnson, N; Bolla, MK; Sawyer, EJ; Tomlinson, I; Kerin, MJ; Miller, N; Marme, F; Burwinkel, B; Yang, R; Guénel, P; Truong, T; Menegaux, F; Sanchez, M; Bojesen, S; Nielsen, SF; Flyger, H; Benitez, J; Zamora, MP; Perez, JIA; Menéndez, P; Anton-Culver, H; Neuhausen, S; Ziogas, A; Clarke, CA; Brenner, H; Arndt, V; Stegmaier, C; Brauch, H; Brüning, T; Ko, Y-D; Muranen, TA; Aittomäki, K; Blomqvist, C; Bogdanova, NV; Antonenkova, NN; Lindblom, A; Margolin, S; Mannermaa, A; Kataja, V; Kosma, V-M; Hartikainen, JM; Spurdle, AB; Investigators, K; Australian Ovarian Cancer Study Group; Wauters, E; Smeets, D; Beuselinck, B; Floris, G; Chang-Claude, J; Rudolph, A; Seibold, P; Flesch-Janys, D; Olson, JE; Vachon, C; Pankratz, VS; McLean, C; Haiman, CA; Henderson, BE; Schumacher, F; Le Marchand, L; Kristensen, V; Alnæs, GG; Zheng, W; Hunter, DJ; Lindstrom, S; Hankinson, SE; Kraft, P; Andrulis, I; Knight, JA; Glendon, G; Mulligan, AM; Jukkola-Vuorinen, A; Grip, M; Kauppila, S; Devilee, P; Tollenaar, RAEM; Seynaeve, C; Hollestelle, A; Garcia-Closas, M; Figueroa, J; Chanock, SJ; Lissowska, J; Czene, K; Darabi, H; Eriksson, M; Eccles, DM; Rafiq, S; Tapper, WJ; Gerty, SM; Hooning, MJ; Martens, JWM; Collée, JM; Tilanus-Linthorst, M; Hall, P; Li, J; Brand, JS; Humphreys, K; Cox, A; Reed, MWR; Luccarini, C; Baynes, C; Dunning, AM; Hamann, U; Torres, D; Ulmer, HU; Rüdiger, T; Jakubowska, A; Lubinski, J; Jaworska, K; Durda, K; Slager, S; Toland, AE; Ambrosone, CB; Yannoukakos, D; Swerdlow, A; Ashworth, A; Orr, N; Jones, M; González-Neira, A; Pita, G; Alonso, MR; Álvarez, N; Herrero, D; Tessier, DC; Vincent, D; Bacot, F; Simard, J; Dumont, M; Soucy, P; Eeles, R; Muir, K; Wiklund, F; Gronberg, H; Schleutker, J; Nordestgaard, BG; Weischer, M; Travis, RC; Neal, D; Donovan, JL; Hamdy, FC; Khaw, K-T; Stanford, JL; Blot, WJ; Thibodeau, S; Schaid, DJ; Kelley, JL; Maier, C; Kibel, AS; Cybulski, C; Cannon-Albright, L; Butterbach, K; Park, J; Kaneva, R; Batra, J; Teixeira, MR; Kote-Jarai, Z; Olama, AAA; Benlloch, S; Renner, SP; Hartmann, A; Hein, A; Ruebner, M; Lambrechts, D; Van Nieuwenhuysen, E; Vergote, I; Lambretchs, S; Doherty, JA; Rossing, MA; Nickels, S; Eilber, U; Wang-Gohrke, S; Odunsi, K; Sucheston-Campbell, LE; Friel, G; Lurie, G; Killeen, JL; Wilkens, LR; Goodman, MT; Runnebaum, I; Hillemanns, PA; Pelttari, LM; Butzow, R; Modugno, F; Edwards, RP; Ness, RB; Moysich, KB; du Bois, A; Heitz, F; Harter, P; Kommoss, S; Karlan, BY; Walsh, C; Lester, J; Jensen, A; Kjaer, SK; Høgdall, E; Peissel, B; Bonanni, B; Bernard, L; Goode, EL; Fridley, BL; Vierkant, RA; Cunningham, JM; Larson, MC; Fogarty, ZC; Kalli, KR; Liang, D; Lu, KH; Hildebrandt, MAT; Wu, X; Levine, DA; Dao, F; Bisogna, M; Berchuck, A; Iversen, ES; Marks, JR; Akushevich, L; Cramer, DW; Schildkraut, J; Terry, KL; Poole, EM; Stampfer, M; Tworoger, SS; Bandera, EV; Orlow, I; Olson, SH; Bjorge, L; Salvesen, HB; van Altena, AM; Aben, KKH; Kiemeney, LA; Massuger, LFAG; Pejovic, T; Bean, Y; Brooks-Wilson, A; Kelemen, LE; Cook, LS; Le, ND; Górski, B; Gronwald, J; Menkiszak, J; Høgdall, CK; Lundvall, L; Nedergaard, L; Engelholm, SA; Dicks, E; Tyrer, J; Campbell, I; McNeish, I; Paul, J; Siddiqui, N; Glasspool, R; Whittemore, AS; Rothstein, JH; McGuire, V; Sieh, W; Cai, H; Shu, X-O; Teten, RT; Sutphen, R; McLaughlin, JR; Narod, SA; Phelan, CM; Monteiro, AN; Fenstermacher, D; Lin, H-Y; Permuth, JB; Sellers, TA; Chen, YA; Tsai, Y-Y; Chen, Z; Gentry-Maharaj, A; Gayther, SA; Ramus, SJ; Menon, U; Wu, AH; Pearce, CL; Van Den Berg, D; Pike, MC; Dansonka-Mieszkowska, A; Plisiecka-Halasa, J; Moes-Sosnowska, J; Kupryjanczyk, J; Pharoah, PD; Song, H; Winship, I; Chenevix-Trench, G; Giles, GG; Tavtigian, SV; Easton, DF; Milne, RL (2016-12)
      Background The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are ...
    • Pan-cancer analysis of whole genomes. 

      ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (2020-02-05)
      Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale<sup>1-3</sup>. Here we report the integrative analysis ...
    • Partial breast radiotherapy after breast conservation surgery for early breast cancer: 5-year outcomes from the IMPORT LOW (CRUK/06/003) phase III randomised controlled trial 

      Coles, C; Griffin, C; Kirby, A; Titley, J; Agrawal, R; Alhasso, A; Bhattacharya, I; Brunt, M; Ciurlionis, L; Chan, C; Donovan, E; Emson, M; Harnett, A; Haviland, J; Hopwood, P; Jefford, M; Kaggwa, R; Sawyer, E; Syndikus, I; Tsang, Y; Wheatley, D; Wilcox, M; Yarnold, J; Bliss, J
    • Partial-breast radiotherapy after breast conservation surgery for patients with early breast cancer (UK IMPORT LOW trial): 5-year results from a multicentre, randomised, controlled, phase 3, non-inferiority trial. 

      Coles, CE; Griffin, CL; Kirby, AM; Titley, J; Agrawal, RK; Alhasso, A; Bhattacharya, IS; Brunt, AM; Ciurlionis, L; Chan, C; Donovan, EM; Emson, MA; Harnett, AN; Haviland, JS; Hopwood, P; Jefford, ML; Kaggwa, R; Sawyer, EJ; Syndikus, I; Tsang, YM; Wheatley, DA; Wilcox, M; Yarnold, JR; Bliss, JM; IMPORT Trialists (2017-09)
      Background Local cancer relapse risk after breast conservation surgery followed by radiotherapy has fallen sharply in many countries, and is influenced by patient age and clinicopathological factors. We hypothesise that ...
    • Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. 

      Vlachogiannis, G; Hedayat, S; Vatsiou, A; Jamin, Y; Fernández-Mateos, J; Khan, K; Lampis, A; Eason, K; Huntingford, I; Burke, R; Rata, M; Koh, D-M; Tunariu, N; Collins, D; Hulkki-Wilson, S; Ragulan, C; Spiteri, I; Moorcraft, SY; Chau, I; Rao, S; Watkins, D; Fotiadis, N; Bali, M; Darvish-Damavandi, M; Lote, H; Eltahir, Z; Smyth, EC; Begum, R; Clarke, PA; Hahne, JC; Dowsett, M; de Bono, J; Workman, P; Sadanandam, A; Fassan, M; Sansom, OJ; Eccles, S; Starling, N; Braconi, C; Sottoriva, A; Robinson, SP; Cunningham, D; Valeri, N (2018-02)
      Patient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has remained unclear. We report on a living biobank of PDOs from ...
    • Patient-Reported Outcomes Over 5 Years After Whole- or Partial-Breast Radiotherapy: Longitudinal Analysis of the IMPORT LOW (CRUK/06/003) Phase III Randomized Controlled Trial. 

      Bhattacharya, IS; Haviland, JS; Kirby, AM; Kirwan, CC; Hopwood, P; Yarnold, JR; Bliss, JM; Coles, CE; IMPORT Trialists (2019-02)
      Purpose IMPORT LOW demonstrated noninferiority of partial-breast and reduced-dose radiotherapy versus whole-breast radiotherapy for local relapse and similar or reduced toxicity at 5 years. Comprehensive patient-reported ...
    • Patient-reported outcomes with nivolumab in advanced solid cancers. 

      Tykodi, SS; Schadendorf, D; Cella, D; Reck, M; Harrington, K; Wagner, S; Shaw, JW (2018-11)
      Patients with recurrent or metastatic cancer commonly suffer from debilitating toxicity associated with conventional treatment modalities, as well as disease-related symptoms, often with a concomitant negative impact on ...
    • Patient-reported Quality of Life Outcomes in Patients Treated for Muscle-invasive Bladder Cancer with Radiotherapy ± Chemotherapy in the BC2001 Phase III Randomised Controlled Trial. 

      Huddart, RA; Hall, E; Lewis, R; Porta, N; Crundwell, M; Jenkins, PJ; Rawlings, C; Tremlett, J; Campani, L; Hendron, C; Hussain, SA; James, ND; BC2001 Investigators (2020-02)
      Background BC2001, the largest randomised trial of bladder-sparing treatment for muscle-invasive bladder cancer, demonstrated improvement of local control and bladder cancer-specific survival from the addition of concomitant ...
    • Patients choose certainty over burden in bladder cancer surveillance 

      van Osch, FHM; Nekeman, D; Aaronson, NK; Billingham, LJ; James, ND; Cheng, KK; Bryan, RT; Zeegers, MP (Springer Science and Business Media LLC, 2019-12)
    • PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours. 

      Dillon, MT; Boylan, Z; Smith, D; Guevara, J; Mohammed, K; Peckitt, C; Saunders, M; Banerji, U; Clack, G; Smith, SA; Spicer, JF; Forster, MD; Harrington, KJ (2018-08)
      PATRIOT is a phase I study of the ATR inhibitor, AZD6738, as monotherapy, and in combination with palliative radiotherapy. Here, we describe the protocol for this study, which opened in 2014 and is currently recruiting and ...
    • Patritumab or placebo, with cetuximab plus platinum therapy in recurrent or metastatic squamous cell carcinoma of the head and neck: A randomised phase II study. 

      Forster, MD; Dillon, MT; Kocsis, J; Remenár, É; Pajkos, G; Rolland, F; Greenberg, J; Harrington, KJ (2019-12)
      BACKGROUND:The fully human monoclonal antibody patritumab blocks HER3 activation, a resistance mechanism to cetuximab, induced by heregulin (HRG). A phase Ib study in recurrent and/or metastatic (R/M) squamous cell carcinoma ...
    • Patritumab with Cetuximab plus Platinum-Containing Therapy in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck: An Open-Label, Phase Ib Study. 

      Dillon, MT; Grove, L; Newbold, KL; Shaw, H; Brown, NF; Mendell, J; Chen, S; Beckman, RA; Jennings, A; Ricamara, M; Greenberg, J; Forster, M; Harrington, KJ (2019-01)
      Purpose Patritumab plus cetuximab with platinum as first-line therapy for patients with recurrent and/or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) was evaluated for safety and to determine the ...
    • Pattern of Progression after Stereotactic Body Radiotherapy for Oligometastatic Prostate Cancer Nodal Recurrences. 

      Ost, P; Jereczek-Fossa, BA; Van As, N; Zilli, T; Tree, A; Henderson, D; Orecchia, R; Casamassima, F; Surgo, A; Miralbell, R; De Meerleer, G
      Aims To report the relapse pattern of stereotactic body radiotherapy (SBRT) for oligorecurrent nodal prostate cancer (PCa).Materials and methods PCa patients with ≤3 lymph nodes (N1/M1a) at the time of recurrence were ...
    • Patterns of practice for adaptive and real-time radiation therapy (POP-ART RT) part I: Intra-fraction breathing motion management. 

      Anastasi, G; Bertholet, J; Poulsen, P; Roggen, T; Garibaldi, C; Tilly, N; Booth, JT; Oelfke, U; Heijmen, B; Aznar, MC (2020-12)
      Purpose The POP-ART RT study aims to determine to what extent and how intra-fractional real-time respiratory motion management (RRMM) and plan adaptation for inter-fractional anatomical changes (ART), are used in clinical ...
    • Patterns of practice for adaptive and real-time radiation therapy (POP-ART RT) part II: Offline and online plan adaption for interfractional changes. 

      Bertholet, J; Anastasi, G; Noble, D; Bel, A; van Leeuwen, R; Roggen, T; Duchateau, M; Pilskog, S; Garibaldi, C; Tilly, N; García-Mollá, R; Bonaque, J; Oelfke, U; Aznar, MC; Heijmen, B (2020-12)
      Purpose The POP-ART RT study aims to determine to what extent and how intrafractional real-time respiratory motion management (RRMM), and plan adaptation for interfractional anatomical changes (ART) are used in clinical ...
    • Patterns of recurrence after prostate bed radiotherapy. 

      Brand, DH; Parker, JI; Dearnaley, DP; Eeles, R; Huddart, R; Khoo, V; Murray, J; Suh, Y-E; Tree, AC; van As, N; Parker, C (2019-12)
      Background and purpose Prostate bed radiotherapy is a standard treatment after radical prostatectomy. Recent evidence suggests that, for patients with a PSA > 0.34 ng/ml, the radiotherapy treatment volume should include ...
    • Pazopanib, a promising option for the treatment of aggressive fibromatosis. 

      Szucs, Z; Messiou, C; Wong, HH; Hatcher, H; Miah, A; Zaidi, S; van der Graaf, WTA; Judson, I; Jones, RL; Benson, C (2017-04)
      Desmoid tumour/aggressive fibromatosis (DT/AF) is a rare soft-tissue neoplasm that is locally aggressive but does not metastasize. There is no standard systemic treatment for symptomatic patients, although a number of ...
    • PD-1 Blockade Following Isolated Limb Perfusion with Vaccinia Virus Prevents Local and Distant Relapse of Soft-tissue Sarcoma. 

      Smith, HG; Mansfield, D; Roulstone, V; Kyula-Currie, JN; McLaughlin, M; Patel, RR; Bergerhoff, KF; Paget, JT; Dillon, MT; Khan, A; Melcher, A; Thway, K; Harrington, KJ; Hayes, AJ (2019-06)
      PURPOSE:The prevention and treatment of metastatic sarcoma are areas of significant unmet need. Immune checkpoint inhibitor monotherapy has shown little activity in sarcoma and there is great interest in identifying novel ...