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'Relationship between thermal dose and cell death for "rapid" ablative and "slow" hyperthermic heating'.
(TAYLOR & FRANCIS LTD, 2019-01-01)
AIM: Thermal isoeffective dose (TID) has not been convincingly validated for application to predict biological effects from rapid thermal ablation (e.g., using >55 °C). This study compares the classical method of quantifying ...
A cellular automaton model for spheroid response to radiation and hyperthermia treatments.
(NATURE PUBLISHING GROUP, 2019-11-27)
Thermo-radiosensitisation is a promising approach for treatment of radio-resistant tumours such as those containing hypoxic subregions. Response prediction and treatment planning should account for tumour response ...
Combining radiation with hyperthermia: a multiscale model informed by in vitro experiments.
(ROYAL SOC, 2018-01-01)
Combined radiotherapy and hyperthermia offer great potential for the successful treatment of radio-resistant tumours through thermo-radiosensitization. Tumour response heterogeneity, due to intrinsic, or micro-environmentally ...
Focused Ultrasound-Mediated Hyperthermia in Vitro: An Experimental Arrangement for Treating Cells under Tissue-Mimicking Conditions.
(ELSEVIER SCIENCE INC, 2019-12-01)
An experimental arrangement that allows in vitro exposure of cells to focused ultrasound-mediated hyperthermia (43°C-55°C) in a tissue-mimicking phantom with biological, acoustic and thermal properties comparable to those ...
A comprehensive model for heat-induced radio-sensitisation.
(TAYLOR & FRANCIS LTD, 2017-07-05)
Combined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitisation. We propose an empirical cell survival model (AlphaR model) to describe this multimodality ...
3D tumour spheroids for the prediction of the effects of radiation and hyperthermia treatments.
(NATURE PORTFOLIO, 2020-02-03)
For multimodality therapies such as the combination of hyperthermia and radiation, quantification of biological effects is key for dose prescription and response prediction. Tumour spheroids have a microenvironment that ...