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Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) of the normal bone marrow in children and effects of local and systemic cancer therapies
(Institute of Cancer Research (University Of London), 2021-01-31)
Bone marrow, one of the largest organs in the body, is a highly proliferative tissue because of its dynamic function in providing the cellular elements of blood. In a paediatric population, the proportion of red marrow ...
Efficient Online 4D Magnetic Resonance Imaging
(IEEE COMPUTER SOC, 2021-01-01)
Magnetic resonance imaging (MRI) guided radiotherapy for prostate cancer
(Institute of Cancer Research (University Of London), 2020-11-30)
Radiotherapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. Magnetic resonance imaging (MRI) guided radiotherapy allows daily adaptive replanning and can improve ...
Three-dimensional dose verification of adaptive radiotherapy at an MR-linac
(Institute of Cancer Research (University Of London), 2020-04-30)
The vision of accurate real-time image-guided radiotherapy (RT) has led to the development of MR-Linacs consisting of MRI scanners integrated within RT treatment units. The safe clinical operation of these devices requires ...
Monitoring tumour response to extracellular matrix modulation with multiparametric MRI
(Institute of Cancer Research (University Of London), 2022-04-30)
Primary breast tumours are characterised by a dense extracellular matrix (ECM), with accumulation of collagen and hyaluronan (HA). This stromal dense phenotype is associated with tumour progression, metastasis and poor ...
Computational science-enabled radiological pathology for the non-invasive mapping of tumour heterogeneity in childhood neuroblastoma
(Institute of Cancer Research (University Of London), 2021-01-31)
Neuroblastoma is a common childhood solid tumour that accounts for 15% of all cancer paediatric deaths. This thesis addresses key deficiencies in our ability to define, monitor and predict neuroblastoma heterogeneity for ...
Quantitative assessment of patient suitability for magnetic resonance-guided High Intensity Focused Ultrasound Therapy
(Institute of Cancer Research (University Of London), 2021-01-31)
Clinical assessment of a patient's suitability for magnetic resonance-guided high intensity focused ultrasound (MRgHIFU) therapy currently involves subjective judgements based on available diagnostic images and prior ...
Advanced magnetic resonance imaging in lung mesothelioma
(Institute of Cancer Research (University Of London), 2021-07-31)
Malignant pleural mesothelioma (MPM) has a rind-like growth pattern and may have both solid disease and pleural fluid, so it is very challenging to accurately categorize change in tumour burden using size-based tumour ...
Delayed contrast dynamics as marker of regional impairment in pulmonary fibrosis using 5D MRI - a pilot study.
(BRITISH INST RADIOLOGY, 2020-09-01)
OBJECTIVE: To analyse delayed contrast dynamics of fibrotic lesions in interstitial lung disease (ILD) using five dimensional (5D) MRI and to correlate contrast dynamics with disease severity. METHODS: 20 patients (mean ...
Inter-observer agreement of baseline whole body MRI in multiple myeloma.
(BMC, 2020-07-14)
BACKGROUND: Whole body magnetic resonance imaging (MRI) is now incorporated into international guidance for imaging patients with multiple myeloma. The aim of this study was to investigate inter-observer agreement of triple ...