Inter-observer agreement of baseline whole body MRI in multiple myeloma.
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Date
2020-07-14Author
Croft, J
Riddell, A
Koh, D-M
Downey, K
Blackledge, M
Usher, M
Boyd, K
Kaiser, M
Messiou, C
Type
Journal Article
Metadata
Show full item recordAbstract
BACKGROUND: Whole body magnetic resonance imaging (MRI) is now incorporated into international guidance for imaging patients with multiple myeloma. The aim of this study was to investigate inter-observer agreement of triple reported baseline whole-body MRI in myeloma and highlight potential pitfalls. METHODS: Fifty-seven patients with symptomatic myeloma at first presentation or relapse and planned for autologous stem cell transplant were included. All patients completed baseline whole body MRI within 2 weeks prior to starting treatment. Each scan was reported independently by 3 radiologists using a defined scoring system. Differences in observer scores were compared using analysis of variance (ANOVA) and inter-observer agreement assessed using intra class correlation coefficient (ICC). RESULTS: There was no significant difference in mean observer scores for whole skeleton and ICC demonstrated excellent inter-observer agreement at 0.91. ICC varied between skeletal regions with spine, pelvis and ribs showing good inter-observer agreement, whereas skull and long bones were moderate. Scans with variation in observer scores were re-examined and cause of discrepancies identified. This information was used to describe potential anatomical pitfalls in reporting . CONCLUSION: Whole-body MRI has excellent inter-observer agreement in reporting symptomatic myeloma at baseline. Inter-observer agreement varied between skeletal regions highlighting specific areas of difficulty.
Collections
Subject
Humans
Multiple Myeloma
Observer Variation
Magnetic Resonance Imaging
Reproducibility of Results
Middle Aged
Female
Male
Whole Body Imaging
Research team
Myeloma Group
Computational Imaging
Language
eng
Date accepted
2020-07-08
License start date
2020-07-14
Citation
Cancer imaging : the official publication of the International Cancer Imaging Society, 2020, 20 (1), pp. 48 - ?
Publisher
BMC