MRI-guided lung SBRT: Present and future developments.
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Date
2017-12-01Author
Menten, MJ
Wetscherek, A
Fast, MF
Type
Journal Article
Metadata
Show full item recordAbstract
Stereotactic body radiotherapy (SBRT) is rapidly becoming an alternative to surgery for the treatment of early-stage non-small cell lung cancer patients. Lung SBRT is administered in a hypo-fractionated, conformal manner, delivering high doses to the target. To avoid normal-tissue toxicity, it is crucial to limit the exposure of nearby healthy organs-at-risk (OAR). Current image-guided radiotherapy strategies for lung SBRT are mostly based on X-ray imaging modalities. Although still in its infancy, magnetic resonance imaging (MRI) guidance for lung SBRT is not exposure-limited and MRI promises to improve crucial soft-tissue contrast. Looking beyond anatomical imaging, functional MRI is expected to inform treatment decisions and adaptations in the future. This review summarises and discusses how MRI could be advantageous to the different links of the radiotherapy treatment chain for lung SBRT: diagnosis and staging, tumour and OAR delineation, treatment planning, and inter- or intrafractional motion management. Special emphasis is placed on a new generation of hybrid MRI treatment devices and their potential for real-time adaptive radiotherapy.
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Subject
Humans
Lung Neoplasms
Magnetic Resonance Imaging
Radiosurgery
Radiotherapy, Image-Guided
Research team
Radiotherapy Physics Modelling
Language
eng
Date accepted
2017-02-07
License start date
2017-12
Citation
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2017, 44 pp. 139 - 149
Publisher
ELSEVIER SCI LTD