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dc.contributor.authorBrouckaert, Oen_US
dc.contributor.authorRudolph, Aen_US
dc.contributor.authorLaenen, Aen_US
dc.contributor.authorKeeman, Ren_US
dc.contributor.authorBolla, MKen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorSoubry, Aen_US
dc.contributor.authorWildiers, Hen_US
dc.contributor.authorAndrulis, ILen_US
dc.contributor.authorArndt, Ven_US
dc.contributor.authorBeckmann, MWen_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorBlomqvist, Cen_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorBrauch, Hen_US
dc.contributor.authorBrennan, Pen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.contributor.authorChoi, J-Yen_US
dc.contributor.authorCornelissen, Sen_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorCross, SSen_US
dc.contributor.authorCzene, Ken_US
dc.contributor.authorEriksson, Men_US
dc.contributor.authorFasching, PAen_US
dc.contributor.authorFigueroa, Jen_US
dc.contributor.authorFlyger, Hen_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorGonzález-Neira, Aen_US
dc.contributor.authorGuénel, Pen_US
dc.contributor.authorHall, Pen_US
dc.contributor.authorHollestelle, Aen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorIto, Hen_US
dc.contributor.authorJones, Men_US
dc.contributor.authorKang, Den_US
dc.contributor.authorkConFaben_US
dc.contributor.authorKnight, JAen_US
dc.contributor.authorKosma, V-Men_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorLindblom, Aen_US
dc.contributor.authorLilyquist, Jen_US
dc.contributor.authorLophatananon, Aen_US
dc.contributor.authorMannermaa, Aen_US
dc.contributor.authorManoukian, Sen_US
dc.contributor.authorMargolin, Sen_US
dc.contributor.authorMatsuo, Ken_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorPeterlongo, Pen_US
dc.contributor.authorPylkäs, Ken_US
dc.contributor.authorSaajrang, Sen_US
dc.contributor.authorSeynaeve, Cen_US
dc.contributor.authorShen, C-Yen_US
dc.contributor.authorShu, X-Oen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorSwerdlow, Aen_US
dc.contributor.authorTeo, S-Hen_US
dc.contributor.authorTollenaar, RAEMen_US
dc.contributor.authorTruong, Ten_US
dc.contributor.authorTseng, C-Cen_US
dc.contributor.authorvan den Broek, AJen_US
dc.contributor.authorvan Deurzen, CHMen_US
dc.contributor.authorWinqvist, Ren_US
dc.contributor.authorWu, AHen_US
dc.contributor.authorYip, CHen_US
dc.contributor.authorYu, J-Cen_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorMilne, RLen_US
dc.contributor.authorPharoah, PDPen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorSchmidt, MKen_US
dc.contributor.authorGarcia-Closas, Men_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorLambrechts, Den_US
dc.contributor.authorNeven, Pen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2017-11-22T09:31:37Z
dc.date.issued2017-11-07en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/29116004en_US
dc.identifier10.1186/s13058-017-0909-3en_US
dc.identifier.citationBreast Cancer Res, 2017, 19 (1), pp. 119 - ?en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/913
dc.identifier.eissn1465-542Xen_US
dc.identifier.doi10.1186/s13058-017-0909-3en_US
dc.description.abstractBACKGROUND: Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis. METHODS: We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years. RESULTS: Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP. CONCLUSIONS: Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.en_US
dc.format.extent119 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAge at breast cancer diagnosisen_US
dc.subjectAge at first full-time pregnancyen_US
dc.subjectAge at menarcheen_US
dc.subjectBreast cancer subtypeen_US
dc.subjectParityen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectBiomarkers, Tumoren_US
dc.subjectBreast Neoplasmsen_US
dc.subjectCohort Studiesen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMiddle Ageden_US
dc.subjectOdds Ratioen_US
dc.subjectReproductive Historyen_US
dc.subjectRisk Assessmenten_US
dc.subjectRisk Factorsen_US
dc.subjectTriple Negative Breast Neoplasmsen_US
dc.subjectYoung Adulten_US
dc.titleReproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-10-16en_US
rioxxterms.versionofrecord10.1186/s13058-017-0909-3en_US
rioxxterms.licenseref.startdate2017-11-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBreast Cancer Resen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished onlineen_US
pubs.volume19en_US
pubs.embargo.termsNot knownen_US
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorJones, Michaelen_US


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