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dc.contributor.authorBrouckaert, O
dc.contributor.authorRudolph, A
dc.contributor.authorLaenen, A
dc.contributor.authorKeeman, R
dc.contributor.authorBolla, MK
dc.contributor.authorWang, Q
dc.contributor.authorSoubry, A
dc.contributor.authorWildiers, H
dc.contributor.authorAndrulis, IL
dc.contributor.authorArndt, V
dc.contributor.authorBeckmann, MW
dc.contributor.authorBenitez, J
dc.contributor.authorBlomqvist, C
dc.contributor.authorBojesen, SE
dc.contributor.authorBrauch, H
dc.contributor.authorBrennan, P
dc.contributor.authorBrenner, H
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorChoi, J-Y
dc.contributor.authorCornelissen, S
dc.contributor.authorCouch, FJ
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorEriksson, M
dc.contributor.authorFasching, PA
dc.contributor.authorFigueroa, J
dc.contributor.authorFlyger, H
dc.contributor.authorGiles, GG
dc.contributor.authorGonzález-Neira, A
dc.contributor.authorGuénel, P
dc.contributor.authorHall, P
dc.contributor.authorHollestelle, A
dc.contributor.authorHopper, JL
dc.contributor.authorIto, H
dc.contributor.authorJones, M
dc.contributor.authorKang, D
dc.contributor.authorkConFab
dc.contributor.authorKnight, JA
dc.contributor.authorKosma, V-M
dc.contributor.authorLi, J
dc.contributor.authorLindblom, A
dc.contributor.authorLilyquist, J
dc.contributor.authorLophatananon, A
dc.contributor.authorMannermaa, A
dc.contributor.authorManoukian, S
dc.contributor.authorMargolin, S
dc.contributor.authorMatsuo, K
dc.contributor.authorMuir, K
dc.contributor.authorNevanlinna, H
dc.contributor.authorPeterlongo, P
dc.contributor.authorPylkäs, K
dc.contributor.authorSaajrang, S
dc.contributor.authorSeynaeve, C
dc.contributor.authorShen, C-Y
dc.contributor.authorShu, X-O
dc.contributor.authorSouthey, MC
dc.contributor.authorSwerdlow, A
dc.contributor.authorTeo, S-H
dc.contributor.authorTollenaar, RAEM
dc.contributor.authorTruong, T
dc.contributor.authorTseng, C-C
dc.contributor.authorvan den Broek, AJ
dc.contributor.authorvan Deurzen, CHM
dc.contributor.authorWinqvist, R
dc.contributor.authorWu, AH
dc.contributor.authorYip, CH
dc.contributor.authorYu, J-C
dc.contributor.authorZheng, W
dc.contributor.authorMilne, RL
dc.contributor.authorPharoah, PDP
dc.contributor.authorEaston, DF
dc.contributor.authorSchmidt, MK
dc.contributor.authorGarcia-Closas, M
dc.contributor.authorChang-Claude, J
dc.contributor.authorLambrechts, D
dc.contributor.authorNeven, P
dc.date.accessioned2017-11-22T09:31:37Z
dc.date.issued2017-11-07
dc.identifier.citationBreast cancer research : BCR, 2017, 19 (1), pp. 119 - ?
dc.identifier.issn1465-5411
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/913
dc.identifier.eissn1465-542X
dc.identifier.doi10.1186/s13058-017-0909-3
dc.description.abstractBackground Previous studies have shown that reproductive factors are differentially associated with breast cancer (BC) risk by subtypes. The aim of this study was to investigate associations between reproductive factors and BC subtypes, and whether these vary by age at diagnosis.Methods We used pooled data on tumor markers (estrogen and progesterone receptor, human epidermal growth factor receptor-2 (HER2)) and reproductive risk factors (parity, age at first full-time pregnancy (FFTP) and age at menarche) from 28,095 patients with invasive BC from 34 studies participating in the Breast Cancer Association Consortium (BCAC). In a case-only analysis, we used logistic regression to assess associations between reproductive factors and BC subtype compared to luminal A tumors as a reference. The interaction between age and parity in BC subtype risk was also tested, across all ages and, because age was modeled non-linearly, specifically at ages 35, 55 and 75 years.Results Parous women were more likely to be diagnosed with triple negative BC (TNBC) than with luminal A BC, irrespective of age (OR for parity = 1.38, 95% CI 1.16-1.65, p = 0.0004; p for interaction with age = 0.076). Parous women were also more likely to be diagnosed with luminal and non-luminal HER2-like BCs and this effect was slightly more pronounced at an early age (p for interaction with age = 0.037 and 0.030, respectively). For instance, women diagnosed at age 35 were 1.48 (CI 1.01-2.16) more likely to have luminal HER2-like BC than luminal A BC, while this association was not significant at age 75 (OR = 0.72, CI 0.45-1.14). While age at menarche was not significantly associated with BC subtype, increasing age at FFTP was non-linearly associated with TNBC relative to luminal A BC. An age at FFTP of 25 versus 20 years lowered the risk for TNBC (OR = 0.78, CI 0.70-0.88, p < 0.0001), but this effect was not apparent at a later FFTP.Conclusions Our main findings suggest that parity is associated with TNBC across all ages at BC diagnosis, whereas the association with luminal HER2-like BC was present only for early onset BC.
dc.formatElectronic
dc.format.extent119 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectkConFab
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectReproductive History
dc.subjectOdds Ratio
dc.subjectRisk Assessment
dc.subjectRisk Factors
dc.subjectCohort Studies
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectYoung Adult
dc.subjectTriple Negative Breast Neoplasms
dc.subjectBiomarkers, Tumor
dc.titleReproductive profiles and risk of breast cancer subtypes: a multi-center case-only study.
dc.typeJournal Article
dcterms.dateAccepted2017-10-16
rioxxterms.versionofrecord10.1186/s13058-017-0909-3
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-11-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBreast cancer research : BCR
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume19
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiologyen_US
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorJones, Michaelen


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