Advances in the treatment of advanced oestrogen-receptor-positive breast cancer.
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Date
2017-06-17ICR Author
Author
Turner, NC
Neven, P
Loibl, S
Andre, F
Type
Journal Article
Metadata
Show full item recordAbstract
Oestrogen-receptor-positive breast cancer is the most common subtype of breast cancer. Endocrine therapies that target the dependence of this subtype on the oestrogen receptor have substantial activity, yet the development of resistance to therapy is inevitable in advanced cancer. Major progress has been made in identifying the drivers of oestrogen-receptor-positive breast cancer and the mechanisms of resistance to endocrine therapy. This progress has translated into major advances in the treatment of advanced breast cancer, with several targeted therapies that enhance the efficacy of endocrine therapy; inhibitors of mTOR and inhibitors of the cyclin-dependent kinases CDK4 and CDK6 substantially improve progression-free survival. A new wave of targeted therapies is being developed, including inhibitors of PI3K, AKT, and HER2, and a new generation of oestrogen-receptor degraders. Considerable challenges remain in patient selection, deciding on the most appropriate order in which to administer therapies, and establishing whether cross-resistance occurs between therapies.
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Subject
Humans
Breast Neoplasms
Piperazines
Pyridines
Nuclear Proteins
Receptors, Estrogen
Transcription Factors
Antineoplastic Agents
Aromatase Inhibitors
Female
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase 6
TOR Serine-Threonine Kinases
Molecular Targeted Therapy
Research team
Molecular Oncology
Language
eng
Date accepted
2016-08-24
License start date
2017-06
Citation
Lancet (London, England), 2017, 389 (10087), pp. 2403 - 2414
Publisher
ELSEVIER SCIENCE INC