Browsing ICR Divisions by author "Houlston, Richard"
Now showing items 1-20 of 182
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A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1.
Vijayakrishnan, J; Kumar, R; Henrion, MYR; Moorman, AV; Rachakonda, PS; et al. (NATURE PUBLISHING GROUP, 2017-03-01)Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype ... -
A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network study.
Labreche, K; Daniau, M; Sud, A; Law, PJ; Royer-Perron, L; et al. (OXFORD UNIV PRESS INC, 2019-08-05)BACKGROUND: Primary central nervous system lymphoma (PCNSL) is a rare form of extra-nodal non-Hodgkin lymphoma. PCNSL is a distinct subtype of non-Hodgkin lymphoma, with over 95% of tumors belonging to the diffuse large ... -
A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.
Yuan, H; Liu, H; Liu, Z; Owzar, K; Han, Y; et al. (NATURE PORTFOLIO, 2016-10-07)Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 ... -
Age-specific genome-wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'-like features associated with younger age.
Ostrom, QT; Kinnersley, B; Armstrong, G; Rice, T; Chen, Y; et al. (WILEY, 2018-11-15)Glioblastoma (GBM) is the most common malignant brain tumor in the United States. Incidence of GBM increases with age, and younger age-at-diagnosis is significantly associated with improved prognosis. While the relationship ... -
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.
Mueller, SH; Lai, AG; Valkovskaya, M; Michailidou, K; Bolla, MK; et al. (BMC, 2023-01-26)BACKGROUND: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes. METHODS: ... -
Alcohol consumption, DNA methylation and colorectal cancer risk: Results from pooled cohort studies and Mendelian randomization analysis.
Zhou, X; Wang, L; Xiao, J; Sun, J; Yu, L; et al. (WILEY, 2022-07-01)Alcohol consumption is thought to be one of the modifiable risk factors for colorectal cancer (CRC). However, the causality and mechanisms by which alcohol exerts its carcinogenic effect are unclear. We evaluated the ... -
Algorithmic considerations when analysing capture Hi-C data.
Disney-Hogg, L; Kinnersley, B; Houlston, R (2020-01-01)Chromosome conformation capture methodologies have provided insight into the effect of 3D genomic architecture on gene regulation. Capture Hi-C (CHi-C) is a recent extension of Hi-C that improves the effective resolution ... -
An enhanced genetic model of relapsed IGH-translocated multiple myeloma evolutionary dynamics.
Hoang, PH; Cornish, AJ; Sherborne, AL; Chubb, D; Kimber, S; et al. (SPRINGERNATURE, 2020-10-14)Most patients with multiple myeloma (MM) die from progressive disease after relapse. To advance our understanding of MM evolution mechanisms, we performed whole-genome sequencing of 80 IGH-translocated tumour-normal newly ... -
Analysis of 153 115 patients with hematological malignancies refines the spectrum of familial risk.
Sud, A; Chattopadhyay, S; Thomsen, H; Sundquist, K; Sundquist, J; et al. (AMER SOC HEMATOLOGY, 2019-09)Estimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk for malignancy. To gain insight into the familial risk for the different ... -
Analysis of rare disruptive germline mutations in 2135 enriched BRCA-negative breast cancers excludes additional high-impact susceptibility genes.
Loveday, C; Garrett, A; Law, P; Hanks, S; Poyastro-Pearson, E; et al. (ELSEVIER, 2022-12-01)BACKGROUND: Breast cancer has a significant heritable basis, of which ∼60% remains unexplained. Testing for BRCA1/BRCA2 offers useful discrimination of breast cancer risk within families, and identification of additional ... -
Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis.
Amirian, ES; Ostrom, QT; Armstrong, GN; Lai, RK; Gu, X; et al. (AMER ASSOC CANCER RESEARCH, 2019-03-01)BACKGROUND: There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or NSAIDs, and results have been conflicting. The purpose of this study was to examine the ... -
Assessing the effect of obesity-related traits on multiple myeloma using a Mendelian randomisation approach.
Went, M; Sud, A; Law, PJ; Johnson, DC; Weinhold, N; et al. (NATURE PUBLISHING GROUP, 2017-06-16) -
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
Zhang, YD; Hurson, AN; Zhang, H; Choudhury, PP; Easton, DF; et al. (NATURE PORTFOLIO, 2020-07-03)Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of ... -
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Law, PJ; Timofeeva, M; Fernandez-Rozadilla, C; Broderick, P; Studd, J; et al. (NATURE PUBLISHING GROUP, 2019-05-14)Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that ... -
Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival.
Morra, A; Schreurs, MAC; Andrulis, IL; Anton-Culver, H; Augustinsson, A; et al. (WILEY, 2023-08-01)BACKGROUND: Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers. AIM: To assessed the ... -
Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs.
Pan, Y; Liu, H; Wang, Y; Kang, X; Liu, Z; et al. (NATURE PORTFOLIO, 2017-03-17)mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in ... -
Bidirectional Mendelian randomisation analysis of the relationship between circulating vitamin D concentration and colorectal cancer risk.
He, Y; Zhang, X; Timofeeva, M; Farrington, SM; Li, X; et al. (WILEY, 2022-01-15)Epidemiological evidence is consistent with a protective effect of vitamin D against colorectal cancer (CRC), but the observed strong associations are open to confounders and potential reverse causation. Previous Mendelian ... -
Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes
Studd, J; Cornish, A; Hoang, P; Law, P; Houlston, R (2021-04-15)To obtain a comprehensive picture of composite genetic drivers events and clonal dynamics in subtypes of paediatric acute lymphoblastic leukaemia (ALL) we analysed tumour-normal whole genome sequencing and expression data ... -
Cancer drivers and clonal dynamics in acute lymphoblastic leukaemia subtypes.
Studd, JB; Cornish, AJ; Hoang, PH; Law, P; Kinnersley, B; et al. (SPRINGERNATURE, 2021-11-09)To obtain a comprehensive picture of composite genetic driver events and clonal dynamics in subtypes of paediatric acute lymphoblastic leukaemia (ALL) we analysed tumour-normal whole genome sequencing and expression data ... -
Cancer genetics, precision prevention and a call to action.
Turnbull, C; Sud, A; Houlston, RS (NATURE PUBLISHING GROUP, 2018-09-01)More than 15 years have passed since the identification, through linkage, of 'first-wave' susceptibility genes for common cancers (BRCA1, BRCA2, MLH1 and MSH2). These genes have strong frequency-penetrance profiles, such ...