A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.
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Date
2016-10-07ICR Author
Author
Yuan, H
Liu, H
Liu, Z
Owzar, K
Han, Y
Su, L
Wei, Y
Hung, RJ
McLaughlin, J
Brhane, Y
Brennan, P
Bickeboeller, H
Rosenberger, A
Houlston, RS
Caporaso, N
Landi, MT
Heinrich, J
Risch, A
Christiani, DC
Gümüş, ZH
Klein, RJ
Amos, CI
Wei, Q
Type
Journal Article
Metadata
Show full item recordAbstract
Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value < 1 × 10-7) were further validated in two additional independent lung cancer GWAS datasets from Harvard University and deCODE. In the final meta-analysis of all eight GWAS datasets with 17,153 cases and 239,337 controls, a novel risk SNP rs114020893 in the lncRNA NEXN-AS1 region at 1p31.1 remained statistically significant (odds ratio = 1.17; 95% confidence interval = 1.11-1.24; P = 8.31 × 10-9). In further in silico analysis, rs114020893 was predicted to change the secondary structure of the lncRNA. Our finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility.
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Subject
Humans
Lung Neoplasms
Risk Factors
Nucleic Acid Conformation
Polymorphism, Single Nucleotide
Female
Male
Genome-Wide Association Study
RNA, Long Noncoding
Research team
Cancer Genomics
Language
eng
Date accepted
2016-09-06
License start date
2016-10-07
Citation
Scientific reports, 2016, 6 pp. 34234 - ?
Publisher
NATURE PORTFOLIO