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dc.contributor.authorYuan, H
dc.contributor.authorLiu, H
dc.contributor.authorLiu, Z
dc.contributor.authorOwzar, K
dc.contributor.authorHan, Y
dc.contributor.authorSu, L
dc.contributor.authorWei, Y
dc.contributor.authorHung, RJ
dc.contributor.authorMcLaughlin, J
dc.contributor.authorBrhane, Y
dc.contributor.authorBrennan, P
dc.contributor.authorBickeboeller, H
dc.contributor.authorRosenberger, A
dc.contributor.authorHoulston, RS
dc.contributor.authorCaporaso, N
dc.contributor.authorLandi, MT
dc.contributor.authorHeinrich, J
dc.contributor.authorRisch, A
dc.contributor.authorChristiani, DC
dc.contributor.authorGümüş, ZH
dc.contributor.authorKlein, RJ
dc.contributor.authorAmos, CI
dc.contributor.authorWei, Q
dc.date.accessioned2020-10-21T13:06:03Z
dc.date.issued2016-10-07
dc.identifier.citationScientific reports, 2016, 6 pp. 34234 - ?
dc.identifier.issn2045-2322
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4180
dc.identifier.eissn2045-2322
dc.identifier.doi10.1038/srep34234
dc.description.abstractLung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value < 1 × 10-7) were further validated in two additional independent lung cancer GWAS datasets from Harvard University and deCODE. In the final meta-analysis of all eight GWAS datasets with 17,153 cases and 239,337 controls, a novel risk SNP rs114020893 in the lncRNA NEXN-AS1 region at 1p31.1 remained statistically significant (odds ratio = 1.17; 95% confidence interval = 1.11-1.24; P = 8.31 × 10-9). In further in silico analysis, rs114020893 was predicted to change the secondary structure of the lncRNA. Our finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility.
dc.formatElectronic
dc.format.extent34234 - ?
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectRisk Factors
dc.subjectNucleic Acid Conformation
dc.subjectPolymorphism, Single Nucleotide
dc.subjectFemale
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectRNA, Long Noncoding
dc.titleA Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.
dc.typeJournal Article
dcterms.dateAccepted2016-09-06
rioxxterms.versionofrecord10.1038/srep34234
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-10-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfScientific reports
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume6
pubs.embargo.termsNot known
icr.researchteamCancer Genomics
dc.contributor.icrauthorHoulston, Richard


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