dc.contributor.author | Yuan, H | |
dc.contributor.author | Liu, H | |
dc.contributor.author | Liu, Z | |
dc.contributor.author | Owzar, K | |
dc.contributor.author | Han, Y | |
dc.contributor.author | Su, L | |
dc.contributor.author | Wei, Y | |
dc.contributor.author | Hung, RJ | |
dc.contributor.author | McLaughlin, J | |
dc.contributor.author | Brhane, Y | |
dc.contributor.author | Brennan, P | |
dc.contributor.author | Bickeboeller, H | |
dc.contributor.author | Rosenberger, A | |
dc.contributor.author | Houlston, RS | |
dc.contributor.author | Caporaso, N | |
dc.contributor.author | Landi, MT | |
dc.contributor.author | Heinrich, J | |
dc.contributor.author | Risch, A | |
dc.contributor.author | Christiani, DC | |
dc.contributor.author | Gümüş, ZH | |
dc.contributor.author | Klein, RJ | |
dc.contributor.author | Amos, CI | |
dc.contributor.author | Wei, Q | |
dc.date.accessioned | 2020-10-21T13:06:03Z | |
dc.date.issued | 2016-10-07 | |
dc.identifier.citation | Scientific reports, 2016, 6 pp. 34234 - ? | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4180 | |
dc.identifier.eissn | 2045-2322 | |
dc.identifier.doi | 10.1038/srep34234 | |
dc.description.abstract | Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value < 1 × 10-7) were further validated in two additional independent lung cancer GWAS datasets from Harvard University and deCODE. In the final meta-analysis of all eight GWAS datasets with 17,153 cases and 239,337 controls, a novel risk SNP rs114020893 in the lncRNA NEXN-AS1 region at 1p31.1 remained statistically significant (odds ratio = 1.17; 95% confidence interval = 1.11-1.24; P = 8.31 × 10-9). In further in silico analysis, rs114020893 was predicted to change the secondary structure of the lncRNA. Our finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility. | |
dc.format | Electronic | |
dc.format.extent | 34234 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Lung Neoplasms | |
dc.subject | Risk Factors | |
dc.subject | Nucleic Acid Conformation | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Genome-Wide Association Study | |
dc.subject | RNA, Long Noncoding | |
dc.title | A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-09-06 | |
rioxxterms.versionofrecord | 10.1038/srep34234 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-10-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Scientific reports | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.publication-status | Published | |
pubs.volume | 6 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Cancer Genomics | |
dc.contributor.icrauthor | Houlston, Richard | |