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Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis.

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Date
2019-03
ICR Author
Houlston, Richard
Author
Amirian, ES
Ostrom, QT
Armstrong, GN
Lai, RK
Gu, X
Jacobs, DI
Jalali, A
Claus, EB
Barnholtz-Sloan, JS
Il'yasova, D
Schildkraut, JM
Ali-Osman, F
Sadetzki, S
Jenkins, RB
Lachance, DH
Olson, SH
Bernstein, JL
Merrell, RT
Wrensch, MR
Johansen, C
Houlston, RS
Scheurer, ME
Shete, S
Amos, CI
Melin, B
Bondy, ML
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Type
Journal Article
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Abstract
Background There have been few studies of sufficient size to address the relationship between glioma risk and the use of aspirin or NSAIDs, and results have been conflicting. The purpose of this study was to examine the associations between glioma and aspirin/NSAID use, and to aggregate these findings with prior published studies using meta-analysis.Methods The Glioma International Case-Control Study (GICC) consists of 4,533 glioma cases and 4,171 controls recruited from 2010 to 2013. Interviews were conducted using a standardized questionnaire to obtain information on aspirin/NSAID use. We examined history of regular use for ≥6 months and duration-response. Restricted maximum likelihood meta-regression models were used to aggregate site-specific estimates, and to combine GICC estimates with previously published studies.Results A history of daily aspirin use for ≥6 months was associated with a 38% lower glioma risk, compared with not having a history of daily use [adjusted meta-OR = 0.62; 95% confidence interval (CI), 0.54-0.70]. There was a significant duration-response trend ( P = 1.67 × 10 -17 ), with lower ORs for increasing duration of aspirin use. Duration-response trends were not observed for NSAID use. In the meta-analysis aggregating GICC data with five previous studies, there was a marginally significant association between use of aspirin and glioma (mOR = 0.84; 95% CI, 0.70-1.02), but no association for NSAID use.Conclusions Our study suggests that aspirin may be associated with a reduced risk of glioma.Impact These results imply that aspirin use may be associated with decreased glioma risk. Further research examining the association between aspirin use and glioma risk is warranted.
URI
https://repository.icr.ac.uk/handle/internal/3177
DOI
https://doi.org/10.1158/1055-9965.epi-18-0702
Collections
  • Genetics and Epidemiology
Subject
Humans
Glioma
Brain Neoplasms
Aspirin
Anti-Inflammatory Agents, Non-Steroidal
Prognosis
Risk Assessment
Case-Control Studies
International Agencies
Research team
Cancer Genomics
Language
eng
Date accepted
2018-11-13
License start date
2019-03
Citation
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019, 28 (3), pp. 555 - 562

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