Browsing ICR Divisions by author "Khorashad, Jamshid"
Now showing items 1-4 of 4
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A Role for the Bone Marrow Microenvironment in Drug Resistance of Acute Myeloid Leukemia
Bolandi, SM; Pakjoo, M; Beigi, P; Kiani, M; Allahgholipour, A; et al. (MDPI AG, 2021-10-21)<jats:p>Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis and remarkable resistance to chemotherapeutic agents. Understanding resistance mechanisms against currently available drugs helps to ... -
Carfilzomib Enhances the Suppressive Effect of Ruxolitinib in Myelofibrosis.
Claudiani, S; Mason, CC; Milojkovic, D; Bianchi, A; Pellegrini, C; et al. (MDPI, 2021-09-28)As the first FDA-approved tyrosine kinase inhibitor for treatment of patients with myelofibrosis (MF), ruxolitinib improves clinical symptoms but does not lead to eradication of the disease or significant reduction of the ... -
Genomic Abnormalities as Biomarkers and Therapeutic Targets in Acute Myeloid Leukemia.
Ribeiro, S; Eiring, AM; Khorashad, JS (MDPI, 2021-10-09)Acute myeloid leukemia (AML) is a highly heterogeneous malignancy characterized by the clonal expansion of myeloid stem and progenitor cells in the bone marrow, peripheral blood, and other tissues. AML results from the ... -
MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis
Zhao, H; Pomicter, AD; Eiring, AM; Franzini, A; Ahmann, J; et al. (American Society of Hematology, 2022-02-03)<jats:title>Abstract</jats:title> <jats:p>The chronic phase of chronic myeloid leukemia (CP-CML) is characterized by the excessive production of maturating myeloid cells. As CML stem/progenitor cells (LSPCs) ...