Browsing ICR Divisions by author "Doran, Simon"
Now showing items 21-30 of 30
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Issues involved in the quantitative 3D imaging of proton doses using optical CT and chemical dosimeters.
Doran, S; Gorjiara, T; Kacperek, A; Adamovics, J; Kuncic, Z; et al. (IOP PUBLISHING LTD, 2015-01-21)Dosimetry of proton beams using 3D imaging of chemical dosimeters is complicated by a variation with proton linear energy transfer (LET) of the dose-response (the so-called 'quenching effect'). Simple theoretical arguments ... -
Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review.
Denholm, R; De Stavola, B; Hipwell, JH; Doran, SJ; Busana, MC; et al. (BMC, 2016-10-12)BACKGROUND: Breast density, the amount of fibroglandular tissue in the adult breast for a women's age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, ... -
Prospective, longitudinal, multi-modal functional imaging for radical chemo-IMRT treatment of locally advanced head and neck cancer: the INSIGHT study.
Welsh, L; Panek, R; McQuaid, D; Dunlop, A; Schmidt, M; et al. (BIOMED CENTRAL LTD, 2015-05-15)BACKGROUND: Radical chemo-radiotherapy (CRT) is an effective organ-sparing treatment option for patients with locally advanced head and neck cancer (LAHNC). Despite advances in treatment for LAHNC, a significant minority ... -
Radiomic features of cervical cancer on T2-and diffusion-weighted MRI: Prognostic value in low-volume tumors suitable for trachelectomy.
Wormald, BW; Doran, SJ; Ind, TE; D'Arcy, J; Petts, J; et al. (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020-01-01)BACKGROUND: Textural features extracted from MRI potentially provide prognostic information additional to volume for influencing surgical management of cervical cancer. PURPOSE: To identify textural features that differ ... -
A radiomics-based decision support tool improves lung cancer diagnosis in combination with the Herder score in large lung nodules.
Hunter, B; Chen, M; Ratnakumar, P; Alemu, E; Logan, A; et al. (ELSEVIER, 2022-12-01)BACKGROUND: Large lung nodules (≥15 mm) have the highest risk of malignancy, and may exhibit important differences in phenotypic or clinical characteristics to their smaller counterparts. Existing risk models do not stratify ... -
"Real-world" radiomics from multi-vendor MRI: an original retrospective study on the prediction of nodal status and disease survival in breast cancer, as an exemplar to promote discussion of the wider issues.
Doran, SJ; Kumar, S; Orton, M; d'Arcy, J; Kwaks, F; et al. (BMC, 2021-05-20)BACKGROUND: Most MRI radiomics studies to date, even multi-centre ones, have used "pure" datasets deliberately accrued from single-vendor, single-field-strength scanners. This does not reflect aspirations for the ultimate ... -
Repeatability and sensitivity of T2* measurements in patients with head and neck squamous cell carcinoma at 3T.
Panek, R; Welsh, L; Dunlop, A; Wong, KH; Riddell, AM; et al. (WILEY-BLACKWELL, 2016-07-01)PURPOSE: To determine whether quantitation of T2* is sufficiently repeatable and sensitive to detect clinically relevant oxygenation levels in head and neck squamous cell carcinoma (HNSCC) at 3T. MATERIALS AND METHODS: Ten ... -
Spatial patterns of tumour growth impact clonal diversification in a computational model and the TRACERx Renal study.
Fu, X; Zhao, Y; Lopez, JI; Rowan, A; Au, L; et al. (NATURE PORTFOLIO, 2022-01-01)Genetic intra-tumour heterogeneity fuels clonal evolution, but our understanding of clinically relevant clonal dynamics remain limited. We investigated spatial and temporal features of clonal diversification in clear cell ... -
Splenic volume as a predictor of treatment response in patients with non-small cell lung cancer receiving immunotherapy.
Castagnoli, F; Doran, S; Lunn, J; Minchom, A; O'Brien, M; et al. (Public Library of Science (PLoS), 2022-01-01)INTRODUCTION: The spleen is a lymphoid organ and we hypothesize that clinical benefit to immunotherapy may present with an increase in splenic volume during treatment. The purpose of this study was to investigate whether ...