Now showing items 1-10 of 689
Calmodulin-independent, agonistic properties of a peptide containing the calmodulin binding site of estrogen receptor alpha
Calmodulin (CaM) contributes to estrogen receptor alpha (ER)-mediated transcription. In order to study the underlying mechanisms, we synthesized a peptide including the CaM binding site: ERalpha17p (P(295)-T(311)). This ...
Synthesis of certain 2'-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5'; evaluation as potential dUTP analogues
Synthesis of certain 2 '-deoxyuridine derivatives containing substituted phenoxy groups attached to C-5 '; Evaluation as potential dUTP analogues. Derivatives of 2 ' -deoxyuridine in which the 5 ' -OH group is replaced by ...
Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition
Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition. Uracil DNA glycosylase (UDG) is a base excision repair enzyme responsible for the removal of uracil ...
A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours
A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours. ZD9331 is an antifolate drug that potently and specifically inhibits thymidylate synthase (TS). In ...
EGFR signaling in invasion, angiogenesis and metastasis
(Humana Press, 2008-09-25)
Tumour invasion and metastasis are the hallmarks of advanced stage cancer and are associated with poor patient prognosis. EGFR is overexpressed in a variety of tumour types and this frequently correlates with a more ...
An evaluation of the performance of HapMap SNP data in a Shanghai Chinese population: Analyses of allele frequency, linkage disequilibrium pattern and tagging SNPs transferability on chromosome Iq2I-q25
Background: The HapMap project aimed to catalog millions of common single nucleotide polymorphisms ( SNPs) in the human genome in four major populations, in order to facilitate association studies of complex diseases. To ...
Prostate epithelial stem cell culture
(KLUWER ACADEMIC PUBL, 2003)
The prostate gland is the site of the second most common cancer in men in the UK, with 9,280 deaths recorded in 2000. Another common disease of the prostate is benign prostatic hyperplasia and both conditions are believed ...
Hypothesis: a novel route for immortalization of epithelial cells by Epstein-Barr virus
Transfection of primate tissue explants with a specific sub-fragment (p31) of EBV DNA results in epithelial (but no other) cells proliferating indefinitely (becoming ‘immortalized’) without evidence of a ‘growth crisis’. ...
Radiotherapy for brain metastases
(SPRINGER-VERLAG LONDON LTD, 2001)
Towards the evaluation of the relevant degrees of freedom in nonlinear partial differential equations
We investigate an operator renormalization group method to extract and describe the relevant degrees of freedom in the evolution of partial differential equations. The proposed renormalization group approach is formulated ...