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Rapid amplification of immunoglobulin heavy chain switch (IGHS) translocation breakpoints using long-distance inverse PCR
(NATURE PUBLISHING GROUP, 2004-12)
Molecular cloning of immunoglobulin heavy chain (IGH) translocation breakpoints identifies genes of biological importance in the development of normal and malignant B cells. Long-distance inverse PCR (LDI-PCR) was first ...
Cyclin D1 by flow cytometry as a useful tool in the diagnosis of B-cell malignancies
(2001)
The translocation (11;14)(q13;q32) and its molecular counterpart the BCL-1 rearrangement are features observed in mantle cell lymphoma (MCL) and less commonly in other B-cell disorders. This rearrangement leads to cyclin ...
Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes
(2001-11)
A novel pentacyclic acridine, 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4), has been identified as a potent inhibitor of telomerase in the cell-free telomeric repeat amplification protocol ...
Predictors of histological disease progression in untreated, localized prostate cancer.
(2007-09)
Active surveillance for early prostate cancer is a policy of close monitoring with radical treatment targeted at cases with evidence of disease progression. There is no consensus on the need for or optimum timing of repeat ...
Effects of mixing metal ions on oxidative DNA damage mediated by a Fenton-type reduction
(PERGAMON-ELSEVIER SCIENCE LTD, 2008-02)
The formation of 8-hydroxy-deoxyguanosine (8-OHdG) and strand breaks in DNA by Fenton-type reactions by mixtures of two of five metal ions, iron (II), cadmium (II), nickel (II), chromium (III) or copper (II), has been ...
Abnormal constitutional karyotypes in patients with neuroblastoma: a report of four new cases and review of 47 others in the literature
(2003)
Anomalies of constitutional karyotype, which have led to the discovery of oncogenes and tumor-suppressor genes in embryonal tumors such as retinoblastoma and Wilms tumor, have, until recently, rarely been reported until ...
In the Yeast Heat Shock Response, Hsf1-Directed Induction of Hsp90 Facilitates the Activation of the Slt2 (Mpk1) Mitogen-Activated Protein Kinase Required for Cell Integrity
(2007-04-01)
Yeast is rendered temperature sensitive with loss of the C-terminal (CT) domain of heat shock transcription factor (Hsf1). This domain loss was found to abrogate heat stimulation of Slt2 (Mpk1), the mitogen-activated protein ...
Carcinoma of the cervix and tobacco smoking: Collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies - International collaboration of epidemiological studies of cervical cancer
(WILEY-LISS, 2006-03-15)
Tobacco smoking has been classified as a cause of cervical cancer, but the effect of different patterns of smoking on risk is unclear. The International Collaboration of Epidemiological Studies of Cervical Cancer has brought ...
Delineation of the minimal region of loss at 13q14 in multiple myeloma
(2003-01)
Previous studies have focused on the incidence and prognostic implications of 13q14 deletions in multiple myeloma (MM), but none has sought to delineate the minimal common deleted region (CDR). In an effort to do so, ...
Calculation of x-ray spectra emerging from an x-ray tube. Part II. X-ray production and filtration in x-ray targets
(AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, 2007-06)
A new approach to the calculation of the x-ray spectrum emerging from an x-ray tube is proposed. Theoretical results for the bremsstrahlung cross section appearing in the literature are summarized. Four different treatments ...