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Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration.
(2005-01)
Membrane blebbing during the apoptotic execution phase results from caspase-mediated cleavage and activation of ROCK I. Here, we show that ROCK activity, myosin light chain (MLC) phosphorylation, MLC ATPase activity, and ...
Chemotaxis towards hyaluronan is dependent on CD44 expression and modulated by cell type variation in CD44-hyaluronan binding.
(COMPANY OF BIOLOGISTS LTD, 2005-11-01)
The accumulation of the extracellular matrix glycosaminoglycan hyaluronan by tumours and tumour-associated stroma promotes cancer cell invasion and metastasis. Using the Dunn chamber chemotaxis assay, we demonstrate for ...
Randomised controlled trial of mammographic screening in women from age 40: predicted mortality based on surrogate outcome measures
(NATURE PUBLISHING GROUP, 2005-03-14)
A trial in the UK to study the effect on mortality from breast cancer of invitation for annual mammography from the age of 40-41, has randomised a total of 160 921 women in the ratio 1 : 2 to the intervention and control ...
The psychological impact of human papillomavirus testing in women with borderline or mildly dyskaryotic cervical smear test results: 6-month follow-up
(NATURE PUBLISHING GROUP, 2005-03-28)
State anxiety (S-STAI-6), distress (GHQ-12), concern and quality of life (EuroQoL-EQ-5D) 6 months after human papillomavirus (HPV) testing in women with borderline or mildly dyskaryotic smear test results were assessed ...
The expected burden of mesothelioma mortality in Great Britain from 2002 to 2050
(NATURE PUBLISHING GROUP, 2005-02-14)
The British mesothelioma register contains all deaths from 1968 to 2001 where mesothelioma was mentioned on the death certificate. These data were used to predict the future burden of mesothelioma mortality in Great Britain. ...
Body fatness and physical activity at young ages and the risk of breast cancer in premenopausal women
(NATURE PUBLISHING GROUP, 2005-10-03)
We examined the relationship between body fatness, sports participation and breast cancer risk in 1560 premenopausal cases and 1548 controls, from three related population-based case - control studies in the UK. Half of ...
Randomised controlled trial of mammographic screening in women from age 40: results of screening in the first 10 years
(NATURE PUBLISHING GROUP, 2005-03-14)
Debate continues over the effectiveness of screening by mammography in women below age 50. We report here on results of screening in the first 10 years of a randomised trial to study the effect on breast cancer mortality ...