The diagnostic value of 18F-FDG-PET/CT and MRI in suspected vertebral osteomyelitis - a prospective study.
View/ Open
Date
2018-05ICR Author
Author
Kouijzer, IJE
Scheper, H
de Rooy, JWJ
Bloem, JL
Janssen, MJR
van den Hoven, L
Hosman, AJF
Visser, LG
Oyen, WJG
Bleeker-Rovers, CP
de Geus-Oei, L-F
Type
Journal Article
Metadata
Show full item recordAbstract
PURPOSE:The aim of this study was to determine the diagnostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. METHODS:From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F-FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others' image interpretation. 18F-FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. RESULTS:For 18F-FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F-FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). CONCLUSION:18F-FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F-FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.
Collections
Subject
Spine
Humans
Osteomyelitis
Fluorodeoxyglucose F18
Radiopharmaceuticals
Positron-Emission Tomography
Tomography, X-Ray Computed
Magnetic Resonance Imaging
Sensitivity and Specificity
Prospective Studies
Adult
Aged
Aged, 80 and over
Middle Aged
Female
Male
Positron Emission Tomography Computed Tomography
Research team
Translational Molecular Imaging
Language
eng
Date accepted
2017-12-10
License start date
2018-05
Citation
European journal of nuclear medicine and molecular imaging, 2018, 45 (5), pp. 798 - 805