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dc.contributor.authorVlachogiannis, G
dc.contributor.authorHedayat, S
dc.contributor.authorVatsiou, A
dc.contributor.authorJamin, Y
dc.contributor.authorFernández-Mateos, J
dc.contributor.authorKhan, K
dc.contributor.authorLampis, A
dc.contributor.authorEason, K
dc.contributor.authorHuntingford, I
dc.contributor.authorBurke, R
dc.contributor.authorRata, M
dc.contributor.authorKoh, D-M
dc.contributor.authorTunariu, N
dc.contributor.authorCollins, D
dc.contributor.authorHulkki-Wilson, S
dc.contributor.authorRagulan, C
dc.contributor.authorSpiteri, I
dc.contributor.authorMoorcraft, SY
dc.contributor.authorChau, I
dc.contributor.authorRao, S
dc.contributor.authorWatkins, D
dc.contributor.authorFotiadis, N
dc.contributor.authorBali, M
dc.contributor.authorDarvish-Damavandi, M
dc.contributor.authorLote, H
dc.contributor.authorEltahir, Z
dc.contributor.authorSmyth, EC
dc.contributor.authorBegum, R
dc.contributor.authorClarke, PA
dc.contributor.authorHahne, JC
dc.contributor.authorDowsett, M
dc.contributor.authorde Bono, J
dc.contributor.authorWorkman, P
dc.contributor.authorSadanandam, A
dc.contributor.authorFassan, M
dc.contributor.authorSansom, OJ
dc.contributor.authorEccles, S
dc.contributor.authorStarling, N
dc.contributor.authorBraconi, C
dc.contributor.authorSottoriva, A
dc.contributor.authorRobinson, SP
dc.contributor.authorCunningham, D
dc.contributor.authorValeri, N
dc.date.accessioned2018-02-14T09:29:00Z
dc.date.issued2018-02-23
dc.identifier.citationScience (New York, N.Y.), 2018, 359 (6378), pp. 920 - 926
dc.identifier.issn0036-8075
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1060
dc.identifier.eissn1095-9203
dc.identifier.doi10.1126/science.aao2774
dc.description.abstractPatient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has remained unclear. We report on a living biobank of PDOs from metastatic, heavily pretreated colorectal and gastroesophageal cancer patients recruited in phase 1/2 clinical trials. Phenotypic and genotypic profiling of PDOs showed a high degree of similarity to the original patient tumors. Molecular profiling of tumor organoids was matched to drug-screening results, suggesting that PDOs could complement existing approaches in defining cancer vulnerabilities and improving treatment responses. We compared responses to anticancer agents ex vivo in organoids and PDO-based orthotopic mouse tumor xenograft models with the responses of the patients in clinical trials. Our data suggest that PDOs can recapitulate patient responses in the clinic and could be implemented in personalized medicine programs.
dc.formatPrint
dc.format.extent920 - 926
dc.languageeng
dc.language.isoeng
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectOrganoids
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectGastrointestinal Neoplasms
dc.subjectNeoplasm Metastasis
dc.subjectPhenylurea Compounds
dc.subjectPyridines
dc.subjectAntineoplastic Agents
dc.subjectXenograft Model Antitumor Assays
dc.subjectGenomics
dc.subjectDrug Resistance, Neoplasm
dc.subjectPrecision Medicine
dc.titlePatient-derived organoids model treatment response of metastatic gastrointestinal cancers.
dc.typeJournal Article
dcterms.dateAccepted2018-01-11
rioxxterms.versionofrecord10.1126/science.aao2774
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2018-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfScience (New York, N.Y.)
pubs.issue6378
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Hit Discovery & Structural Design
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Signal Transduction & Molecular Pharmacology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Gastrointestinal Cancers Clinical Trials
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Gastrointestinal Cancers Clinical Trials/Gastrointestinal Cancers Clinical Trials (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Systems and Precision Cancer Medicine
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology/Hit Discovery & Structural Design
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/16/17 Starting Cohort
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Hit Discovery & Structural Design
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Signal Transduction & Molecular Pharmacology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Gastrointestinal Cancers Clinical Trials
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Gastrointestinal Cancers Clinical Trials/Gastrointestinal Cancers Clinical Trials (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Systems and Precision Cancer Medicine
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Structural Biology/Hit Discovery & Structural Design
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/16/17 Starting Cohort
pubs.publication-statusPublished
pubs.volume359
pubs.embargo.termsNot known
icr.researchteamSignal Transduction & Molecular Pharmacology
icr.researchteamGastrointestinal Cancers Clinical Trials
icr.researchteamMedicine (RMH Smith Cunningham)
icr.researchteamProstate Cancer Targeted Therapy Group
icr.researchteamEndocrinology
icr.researchteamEvolutionary Genomics & Modelling
icr.researchteamFunctional Genomics
icr.researchteamGastrointestinal Cancer Biology and Genomics
icr.researchteamSystems and Precision Cancer Medicine
icr.researchteamPre-Clinical MRI
icr.researchteamHit Discovery & Structural Design
dc.contributor.icrauthorHedayat-Husseyin, Somaieh
dc.contributor.icrauthorJamin, Yann
dc.contributor.icrauthorLampis, Andrea
dc.contributor.icrauthorEason, Katherine
dc.contributor.icrauthorBurke, Rosemary
dc.contributor.icrauthorCollins, David
dc.contributor.icrauthorRagulan, Chanthirika
dc.contributor.icrauthorSpiteri Sagastume, Maria
dc.contributor.icrauthorLote, Hazel
dc.contributor.icrauthorClarke, Paul
dc.contributor.icrauthorHahne, Jens
dc.contributor.icrauthorDe Bono, Johann
dc.contributor.icrauthorWorkman, Paul
dc.contributor.icrauthorBraconi, Chiara
dc.contributor.icrauthorSottoriva, Andrea
dc.contributor.icrauthorRobinson, Simon
dc.contributor.icrauthorValeri, Nicola


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