dc.contributor.author | Vlachogiannis, G | |
dc.contributor.author | Hedayat, S | |
dc.contributor.author | Vatsiou, A | |
dc.contributor.author | Jamin, Y | |
dc.contributor.author | Fernández-Mateos, J | |
dc.contributor.author | Khan, K | |
dc.contributor.author | Lampis, A | |
dc.contributor.author | Eason, K | |
dc.contributor.author | Huntingford, I | |
dc.contributor.author | Burke, R | |
dc.contributor.author | Rata, M | |
dc.contributor.author | Koh, D-M | |
dc.contributor.author | Tunariu, N | |
dc.contributor.author | Collins, D | |
dc.contributor.author | Hulkki-Wilson, S | |
dc.contributor.author | Ragulan, C | |
dc.contributor.author | Spiteri, I | |
dc.contributor.author | Moorcraft, SY | |
dc.contributor.author | Chau, I | |
dc.contributor.author | Rao, S | |
dc.contributor.author | Watkins, D | |
dc.contributor.author | Fotiadis, N | |
dc.contributor.author | Bali, M | |
dc.contributor.author | Darvish-Damavandi, M | |
dc.contributor.author | Lote, H | |
dc.contributor.author | Eltahir, Z | |
dc.contributor.author | Smyth, EC | |
dc.contributor.author | Begum, R | |
dc.contributor.author | Clarke, PA | |
dc.contributor.author | Hahne, JC | |
dc.contributor.author | Dowsett, M | |
dc.contributor.author | de Bono, J | |
dc.contributor.author | Workman, P | |
dc.contributor.author | Sadanandam, A | |
dc.contributor.author | Fassan, M | |
dc.contributor.author | Sansom, OJ | |
dc.contributor.author | Eccles, S | |
dc.contributor.author | Starling, N | |
dc.contributor.author | Braconi, C | |
dc.contributor.author | Sottoriva, A | |
dc.contributor.author | Robinson, SP | |
dc.contributor.author | Cunningham, D | |
dc.contributor.author | Valeri, N | |
dc.date.accessioned | 2018-02-14T09:29:00Z | |
dc.date.issued | 2018-02-23 | |
dc.identifier.citation | Science (New York, N.Y.), 2018, 359 (6378), pp. 920 - 926 | |
dc.identifier.issn | 0036-8075 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1060 | |
dc.identifier.eissn | 1095-9203 | |
dc.identifier.doi | 10.1126/science.aao2774 | |
dc.description.abstract | Patient-derived organoids (PDOs) have recently emerged as robust preclinical models; however, their potential to predict clinical outcomes in patients has remained unclear. We report on a living biobank of PDOs from metastatic, heavily pretreated colorectal and gastroesophageal cancer patients recruited in phase 1/2 clinical trials. Phenotypic and genotypic profiling of PDOs showed a high degree of similarity to the original patient tumors. Molecular profiling of tumor organoids was matched to drug-screening results, suggesting that PDOs could complement existing approaches in defining cancer vulnerabilities and improving treatment responses. We compared responses to anticancer agents ex vivo in organoids and PDO-based orthotopic mouse tumor xenograft models with the responses of the patients in clinical trials. Our data suggest that PDOs can recapitulate patient responses in the clinic and could be implemented in personalized medicine programs. | |
dc.format | Print | |
dc.format.extent | 920 - 926 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Organoids | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Mice | |
dc.subject | Gastrointestinal Neoplasms | |
dc.subject | Neoplasm Metastasis | |
dc.subject | Phenylurea Compounds | |
dc.subject | Pyridines | |
dc.subject | Antineoplastic Agents | |
dc.subject | Xenograft Model Antitumor Assays | |
dc.subject | Genomics | |
dc.subject | Drug Resistance, Neoplasm | |
dc.subject | Precision Medicine | |
dc.title | Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-01-11 | |
rioxxterms.versionofrecord | 10.1126/science.aao2774 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
rioxxterms.licenseref.startdate | 2018-02 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Science (New York, N.Y.) | |
pubs.issue | 6378 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Hit Discovery & Structural Design | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Signal Transduction & Molecular Pharmacology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Gastrointestinal Cancers Clinical Trials | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Gastrointestinal Cancers Clinical Trials/Gastrointestinal Cancers Clinical Trials (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Systems and Precision Cancer Medicine | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology/Hit Discovery & Structural Design | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/16/17 Starting Cohort | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Hit Discovery & Structural Design | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Signal Transduction & Molecular Pharmacology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Gastrointestinal Cancers Clinical Trials | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Gastrointestinal Cancers Clinical Trials/Gastrointestinal Cancers Clinical Trials (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Functional Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Systems and Precision Cancer Medicine | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Pre-Clinical MRI | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Structural Biology/Hit Discovery & Structural Design | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/16/17 Starting Cohort | |
pubs.publication-status | Published | |
pubs.volume | 359 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Signal Transduction & Molecular Pharmacology | |
icr.researchteam | Gastrointestinal Cancers Clinical Trials | |
icr.researchteam | Medicine (RMH Smith Cunningham) | |
icr.researchteam | Prostate Cancer Targeted Therapy Group | |
icr.researchteam | Endocrinology | |
icr.researchteam | Evolutionary Genomics & Modelling | |
icr.researchteam | Functional Genomics | |
icr.researchteam | Gastrointestinal Cancer Biology and Genomics | |
icr.researchteam | Systems and Precision Cancer Medicine | |
icr.researchteam | Pre-Clinical MRI | |
icr.researchteam | Hit Discovery & Structural Design | |
dc.contributor.icrauthor | Hedayat-Husseyin, Somaieh | |
dc.contributor.icrauthor | Jamin, Yann | |
dc.contributor.icrauthor | Lampis, Andrea | |
dc.contributor.icrauthor | Eason, Katherine | |
dc.contributor.icrauthor | Burke, Rosemary | |
dc.contributor.icrauthor | Collins, David | |
dc.contributor.icrauthor | Ragulan, Chanthirika | |
dc.contributor.icrauthor | Spiteri Sagastume, Maria | |
dc.contributor.icrauthor | Lote, Hazel | |
dc.contributor.icrauthor | Clarke, Paul | |
dc.contributor.icrauthor | Hahne, Jens | |
dc.contributor.icrauthor | De Bono, Johann | |
dc.contributor.icrauthor | Workman, Paul | |
dc.contributor.icrauthor | Braconi, Chiara | |
dc.contributor.icrauthor | Sottoriva, Andrea | |
dc.contributor.icrauthor | Robinson, Simon | |
dc.contributor.icrauthor | Valeri, Nicola | |