Browsing Other ICR Research by author "Lord, Christopher"
Now showing items 1-2 of 2
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Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance.
Tarantino, D; Walker, C; Weekes, D; Pemberton, H; Davidson, K; et al. (SPRINGERNATURE, 2022-08-05)HORMAD1 expression is usually restricted to germline cells, but it becomes mis-expressed in epithelial cells in ~60% of triple-negative breast cancers (TNBCs), where it is associated with elevated genomic instability (1). ... -
Systemic Therapy for Hereditary Breast Cancers.
Harvey-Jones, EJ; Lord, CJ; Tutt, ANJ (W B SAUNDERS CO-ELSEVIER INC, 2023-02-01)Approximately 5% to 10% of all breast cancers are hereditary; many of which are caused by pathogenic variants in genes required for homologous recombination, including BRCA1 and BRCA2. Here we discuss systemic treatment ...