Browsing Other ICR Research by author "Pines, Jonathon"
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Delayed APC/C activation extends the first mitosis of mouse embryos.
Ajduk, A; Strauss, B; Pines, J; Zernicka-Goetz, M (Springer Science and Business Media LLC, 2017-08-29)The correct temporal regulation of mitosis underpins genomic stability because it ensures the alignment of chromosomes on the mitotic spindle that is required for their proper segregation to the two daughter cells. Crucially, ... -
The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.
Di Fiore, B; Wurzenberger, C; Davey, NE; Pines, J (CELL PRESS, 2016-12-15)The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex ...