Browsing Other ICR Research by author "Antolin Hernandez, Albert"
Now showing items 1-4 of 4
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AI delivers Michaelis constants as fuel for genome-scale metabolic models.
Antolin, AA; Cascante, M (PUBLIC LIBRARY SCIENCE, 2021-10-20)Michaelis constants (Km) are essential to predict the catalytic rate of enzymes, but are not widely available. A new study in PLOS Biology uses artificial intelligence (AI) to accurately predict Km on a proteome-wide scale, ... -
Dual Inhibitors of PARPs and ROCKs.
Antolín, AA; Mestres, J (AMER CHEMICAL SOC, 2018-10-31)Recent network and system biology analyses suggest that most complex diseases are regulated by robust and highly interconnected pathways that could be better modulated by small molecules binding to multiple biological ... -
Identification of different side effects between PARP inhibitors and their polypharmacological multi-target rationale.
Sandhu, D; Antolin, AA; Cox, AR; Jones, AM (WILEY, 2021-07-30)AIMS: The aim of this study was to determine the differences and potential mechanistic rationale for observed adverse drug reactions (ADRs) between four approved PARP inhibitors (PARPi). METHODS: The Medicines and Healthcare ... -
Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome.
Gray, B; Baruteau, A-E; Antolin, AA; Pittman, A; Sarganas, G; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2022-02-03)BACKGROUND: Acquired long QT syndrome (aLQTS) is a serious unpredictable adverse drug reaction. Pharmacogenomic markers may predict risk. METHODS: Among 153 aLQTS patients (mean age 58 years [range, 14-88], 98.7% White, ...