Browsing Other ICR Research by author "Furness, Andrew"
Now showing items 1-16 of 16
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Challenges in oncology career: are we closing the gender gap? Results of the new ESMO Women for Oncology Committee survey.
Linardou, H; Adjei, AA; Bajpai, J; Banerjee, S; Berghoff, AS; et al. (ELSEVIER, 2023-04-01)BACKGROUND: Following a European Society for Medical Oncology Women for Oncology (ESMO W4O) survey in 2016 showing severe under-representation of female oncologists in leadership roles, ESMO launched a series of initiatives ... -
Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab.
Alexander, JL; Ibraheim, H; Sheth, B; Little, J; Khan, MS; et al. (BMJ PUBLISHING GROUP, 2021-07-01)INTRODUCTION: Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated empirically ... -
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2.
Au, L; Fendler, A; Shepherd, STC; Rzeniewicz, K; Cerrone, M; et al. (NATURE PORTFOLIO, 2021-05-26)Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported ... -
Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective cohort study.
Bai, X; Shaheen, A; Grieco, C; d'Arienzo, PD; Mina, F; et al. (ELSEVIER, 2023-11-01)BACKGROUND: Both dabrafenib/trametinib (D/T) and anti-PD-1 monotherapy (PD-1) are approved adjuvant therapies for patients with stage III BRAF V600-mutant melanoma. However, there is still a lack of head-to-head comparative ... -
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.
Au, L; Hatipoglu, E; Robert de Massy, M; Litchfield, K; Beattie, G; et al. (CELL PRESS, 2021-11-08)ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma (ccRCC) aiming to understand the mechanism ... -
Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study.
Chesney, J; Lewis, KD; Kluger, H; Hamid, O; Whitman, E; et al. (BMJ PUBLISHING GROUP, 2022-12-01)BACKGROUND: Patients with advanced melanoma have limited treatment options after progression on immune checkpoint inhibitors (ICI). Lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, ... -
Female leadership in oncology-has progress stalled? Data from the ESMO W4O authorship and monitoring studies.
Berghoff, AS; Sessa, C; Yang, JC-H; Tsourti, Z; Tsang, J; et al. (ELSEVIER, 2021-12-01)BACKGROUND: Exploratory research showed that female oncologists are frequently under-represented in leadership roles. European Society for Medical Oncology (ESMO) Women for Oncology (W4O) therefore implemented gender ... -
From presentation to paper: Gender disparities in oncological research.
Dijksterhuis, WPM; Stroes, CI; Tan, W-L; Ithimakin, S; Calles, A; et al. (WILEY, 2020-06-01)Gender disparities in scientific publications have been identified in oncological research. Oral research presentations at major conferences enhance visibility of presenters. The share of women presenting at such podia is ... -
Has COVID-19 had a greater impact on female than male oncologists? Results of the ESMO Women for Oncology (W4O) Survey.
Garrido, P; Adjei, AA; Bajpai, J; Banerjee, S; Berghoff, AS; et al. (ELSEVIER, 2021-06-16)BACKGROUND: European Society for Medical Oncology Women for Oncology (ESMO W4O) research has previously shown under-representation of female oncologists in leadership roles. As early reports suggested disproportionate ... -
Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4+PD-1+ Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma.
Alrasheed, N; Lee, L; Ghorani, E; Henry, JY; Conde, L; et al. (AMER ASSOC CANCER RESEARCH, 2020-07-01)PURPOSE: Immune dysregulation is described in multiple myeloma. While preclinical models suggest a role for altered T-cell immunity in disease progression, the contribution of immune dysfunction to clinical outcomes remains ... -
Multiple paternity in superfetatious live-bearing fishes.
Dekker, ML; van Son, LM; Leon-Kloosterziel, KM; Hagmayer, A; Furness, AI; et al. (WILEY, 2022-05-25)Superfetation, the ability to carry several overlapping broods at different developmental stages, has evolved independently multiple times within the live-bearing fish family Poeciliidae. Even though superfetation is ... -
Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis.
Alexander, JL; Ibraheim, H; Richards, C; Shum, B; Pavlidis, P; et al. (BMJ PUBLISHING GROUP, 2022-09-01)INTRODUCTION: Systemic corticosteroids are the mainstay of treatment for immune checkpoint inhibitor induced (CPI) colitis but are associated with complications including life-threatening infection. The topically acting ... -
Pan-cancer deconvolution of tumour composition using DNA methylation.
Chakravarthy, A; Furness, A; Joshi, K; Ghorani, E; Ford, K; et al. (NATURE PUBLISHING GROUP, 2018-08-13)The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a DNA methylation-based approach to tumour cell fraction deconvolution, we report the integrated ... -
The reproductive ecology drivers of egg attendance in amphibians.
Furness, AI; Capellini, I (WILEY, 2022-10-01)Parental care is extremely diverse but, despite much research, why parental care evolves is poorly understood. Here we address this outstanding question using egg attendance, the simplest and most common care form in many ... -
Terrestrial reproduction and parental care drive rapid evolution in the trade-off between offspring size and number across amphibians.
Furness, AI; Venditti, C; Capellini, I; Jennions MD (Public Library of Science (PLoS), 2022-01-01)The trade-off between offspring size and number is central to life history strategies. Both the evolutionary gain of parental care or more favorable habitats for offspring development are predicted to result in fewer, ... -
Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment.
Wong, YNS; Joshi, K; Khetrapal, P; Ismail, M; Reading, JL; et al. (ROCKEFELLER UNIV PRESS, 2018-11-05)Despite the advances in cancer immunotherapy, only a fraction of patients with bladder cancer exhibit responses to checkpoint blockade, highlighting a need to better understand drug resistance and identify rational ...