Now showing items 1-7 of 7

    • Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab. 

      Alexander, JL; Ibraheim, H; Sheth, B; Little, J; Khan, MS; Richards, C; Hunter, N; Chauhan, D; Ratnakumaran, R; McHugh, K; Pinato, DJ; Nathan, P; Choy, J; Crusz, SM; Furness, A; Turajlic, S; Pickering, L; Larkin, J; Teare, JP; Papa, S; Speight, A; Sharma, A; Powell, N
      Introduction Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated empirically ...
    • Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2. 

      Au, L; Fendler, A; Shepherd, STC; Rzeniewicz, K; Cerrone, M; Byrne, F; Carlyle, E; Edmonds, K; Del Rosario, L; Shon, J; Haynes, WA; Ward, B; Shum, B; Gordon, W; Gerard, CL; Xie, W; Joharatnam-Hogan, N; Young, K; Pickering, L; Furness, AJS; Larkin, J; Harvey, R; Kassiotis, G; Gandhi, S; Crick COVID-19 Consortium; Swanton, C; Fribbens, C; Wilkinson, KA; Wilkinson, RJ; Lau, DK; Banerjee, S; Starling, N; Chau, I; CAPTURE Consortium; Turajlic, S (2021-05-26)
      Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported ...
    • From presentation to paper: Gender disparities in oncological research. 

      Dijksterhuis, WPM; Stroes, CI; Tan, W-L; Ithimakin, S; Calles, A; van Oijen, MGH; Verhoeven, RHA; Barriuso, J; Oosting, SF; Ivankovic, DK; Furness, AJS; Bozovic-Spasojevic, I; Gomez-Roca, C; van Laarhoven, HWM (2020-06)
      Gender disparities in scientific publications have been identified in oncological research. Oral research presentations at major conferences enhance visibility of presenters. The share of women presenting at such podia is ...
    • Has COVID-19 had a greater impact on female than male oncologists? Results of the ESMO Women for Oncology (W4O) Survey. 

      Garrido, P; Adjei, AA; Bajpai, J; Banerjee, S; Berghoff, AS; Choo, SP; Felip, E; Furness, AJS; Garralda, E; Haanen, J; Letsch, A; Linardou, H; Peters, S; Sessa, C; Tabernero, J; Tsang, J; Yang, JC-H; Garassino, MC
      Background European Society for Medical Oncology Women for Oncology (ESMO W4O) research has previously shown under-representation of female oncologists in leadership roles. As early reports suggested disproportionate effects ...
    • Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4<sup>+</sup>PD-1<sup>+</sup> Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma. 

      Alrasheed, N; Lee, L; Ghorani, E; Henry, JY; Conde, L; Chin, M; Galas-Filipowicz, D; Furness, AJS; Chavda, SJ; Richards, H; De-Silva, D; Cohen, OC; Patel, D; Brooks, A; Rodriguez-Justo, M; Pule, M; Herrero, J; Quezada, SA; Yong, KL (2020-07)
      Purpose Immune dysregulation is described in multiple myeloma. While preclinical models suggest a role for altered T-cell immunity in disease progression, the contribution of immune dysfunction to clinical outcomes remains ...
    • Pan-cancer deconvolution of tumour composition using DNA methylation. 

      Chakravarthy, A; Furness, A; Joshi, K; Ghorani, E; Ford, K; Ward, MJ; King, EV; Lechner, M; Marafioti, T; Quezada, SA; Thomas, GJ; Feber, A; Fenton, TR (2018-08-13)
      The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a DNA methylation-based approach to tumour cell fraction deconvolution, we report the integrated ...
    • Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment. 

      Wong, YNS; Joshi, K; Khetrapal, P; Ismail, M; Reading, JL; Sunderland, MW; Georgiou, A; Furness, AJS; Ben Aissa, A; Ghorani, E; Oakes, T; Uddin, I; Tan, WS; Feber, A; McGovern, U; Swanton, C; Freeman, A; Marafioti, T; Briggs, TP; Kelly, JD; Powles, T; Peggs, KS; Chain, BM; Linch, MD; Quezada, SA (2018-11)
      Despite the advances in cancer immunotherapy, only a fraction of patients with bladder cancer exhibit responses to checkpoint blockade, highlighting a need to better understand drug resistance and identify rational ...