Browsing Other ICR Research by title
Now showing items 448-467 of 1078
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"I was seen by a radiologist, but unfortunately I can't remember the name and I still have questions. What should I do?" Radiologists should give thoughts to improve service professionalism and patient esteem.
(2020-02-13)BACKGROUND:The aim of the study is to investigate how well patients remember the radiologist's name after a radiological examination, and whether giving the patient a business card improves the patient's perception of the ... -
Ibrutinib in previously treated chronic lymphocytic leukemia patients with autoimmune cytopenias in the RESONATE study
(Springer Science and Business Media LLC, 2017-02) -
Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia
(2014-07)Background In patients with chronic lymphoid leukemia (CLL) or small lymphocytic lymphoma (SLL), a short duration of response to therapy or adverse cytogenetic abnormalities are associated with a poor outcome. We evaluated ... -
Identification of 22 susceptibility loci associated with testicular germ cell tumors.
(2021-07-23)Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without ... -
Identification of different side effects between PARP inhibitors and their polypharmacological multi-target rationale.
(2021-07-30)Aims The aim of this study was to determine the differences and potential mechanistic rationale for observed adverse drug reactions (ADRs) between four approved PARP inhibitors (PARPi).Methods The Medicines and Healthcare ... -
Identification of neutral tumor evolution across cancer types.
(2016-03)Despite extraordinary efforts to profile cancer genomes, interpreting the vast amount of genomic data in the light of cancer evolution remains challenging. Here we demonstrate that neutral tumor evolution results in a ... -
Identification of protein complexes that bind to histone H3 combinatorial modifications using super-SILAC and weighted correlation network analysis.
(2015-02)The large number of chemical modifications that are found on the histone proteins of eukaryotic cells form multiple complex combinations, which can act as recognition signals for reader proteins. We have used peptide capture ... -
Identification of single nucleotide variants using position-specific error estimation in deep sequencing data
(2018-11-23)Background Targeted deep sequencing is a highly effective technology to identify known and novel single nucleotide variants (SNVs) with many applications in translational medicine, disease monitoring and cancer profiling. ... -
Identification of single nucleotide variants using position-specific error estimation in deep sequencing data.
(2019-08-02)Background Targeted deep sequencing is a highly effective technology to identify known and novel single nucleotide variants (SNVs) with many applications in translational medicine, disease monitoring and cancer profiling. ... -
Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase
(WILEY-BLACKWELL, 2007-11)Helicobacter pylori is one of the world’s most successful human pathogens causing gastric ulcers and cancers. A key virulence factor of H. pylori is the Cag pathogenicity island, which encodes a type IV secretion system. ... -
Identifying naturally occurring communities of primary care providers in the English National Health Service in London.
(2020-07-20)Objectives Primary Care Networks (PCNs) are a new organisational hierarchy with wide-ranging responsibilities introduced in the National Health Service (NHS) Long Term Plan. The vision is that PCNs should represent 'natural' ... -
IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer.
Background Activated type 1 insulin-like growth factor receptors (IGF-1Rs) undergo internalisation and nuclear translocation, promoting cell survival. We previously reported that IGF-1R inhibition delays DNA damage repair, ... -
Imaging diagnosis of metastatic breast cancer.
(2020-06-16)Numerous imaging modalities may be used for the staging of women with advanced breast cancer. Although bone scintigraphy and multiplanar-CT are the most frequently used tests, others including PET, MRI and hybrid scans are ... -
Imaging features of primary sites and metastatic patterns of angiosarcoma.
(2021-12-18)Angiosarcomas are rare, aggressive soft tissue sarcomas originating from endothelial cells of lymphatic or vascular origin and associated with a poor prognosis. The clinical and imaging features of angiosarcomas are ... -
Imaging in retroperitoneal soft tissue sarcoma.
(2018-01)Patients with retroperitoneal sarcoma can present to a variety of clinicians with non-specific symptoms and retroperitoneal sarcomas can be incidental findings. Failure to recognize retroperitoneal sarcomas on imaging can ... -
Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945
(AMER ASSOC CANCER RESEARCH, 2008-05-15)The assessment of tissue-specific pharmacodynamics is desirable in the development of tumor-targeted therapies. Plasma deoxyuridine (dUrd) levels, a measure of systemic thymidylate synthase (TS) inhibition, has limited ... -
Immunodeficiency-related lymphoproliferative disorders: Prospective data from the United Kingdom Children’s Cancer Study Group Registry
(2002-08)Clinical data and biological samples were prospectively collected in 42 children with lymphoproliferative disease (LPD) secondary to organ/bone marrow transplant-related immunosuppression (30: 11 liver, 10 heart/lung, 8 ... -
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).
(2014-03)Cereblon (CRBN), the molecular target of lenalidomide and pomalidomide, is a substrate receptor of the cullin ring E3 ubiquitin ligase complex, CRL4(CRBN) . T cell co-stimulation by lenalidomide or pomalidomide is cereblon ... -
Immunomodulatory effects of heat-killed Mycobacterium obuense on human blood dendritic cells
(SAGE Publications, 2017-10)Heat-killed (HK) Mycobacterium obuense is a novel immunomodulator, currently undergoing clinical evaluation as an immunotherapeutic agent in the treatment of cancer. Here, we examined the effect of in vitro exposure to HK ... -
Impact of a national external quality assessment scheme for breast pathology in the UK
(BMJ Publishing Group, 2006)Background: This article presents the results and observed effects of the UK National Health Service Breast Screening Programme (NHSBSP) external quality assurance scheme in breast histopathology. Aims/Methods: The major ...
