Browsing Other ICR Research by publication type "Thesis or Dissertation"
Now showing items 1-14 of 14
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Development of chemical tool compounds targeting the non-catalytic functions of tankyrase
(Institute of Cancer Research (University Of London), 2023-06-16)Tankyrase (TNKS1 and TNKS2) is a promising target in anti-cancer drug discovery due to its role in regulating cellular processes which are dysregulated in cancer. In addition to catalysing the poly(ADP-ribosyl)ation of ... -
Development of novel therapeutic strategies in relapsed advanced/metastatic non-small cell lung cancer
(Institute of Cancer Research (University Of London), 2022-02-28)Recent advances in the treatment of advanced NSCLC include introduction of targeted therapies and immune-checkpoint inhibitors, leading to improvements in survival outcomes. However, significant new challenges and questions ... -
Evaluating MRI biomarkers of tumour hypoxia
(Institute of Cancer Research (University Of London), 2020-12-31)Tumour hypoxia is associated with resistance to radiotherapy and chemotherapy, and represents a major challenge in the treatment of head and neck squamous cell carcinoma (HNSCC). Non-invasive imaging methods to repeatedly ... -
Functional characterisation of EGFR mutations in cancer
(Institute of Cancer Research (University Of London), 2021-08-31)Large-scale pan-cancer sequencing of tumour samples has identified a plethora of epidermal growth factor (EGFR) mutations along the full length of the gene. However, clinical studies have demonstrated that distinct mutations ... -
Identifying common immunological mechanisms in fibrosis: an immunophenotypic analysis of the capsular response to silicone
(Institute of Cancer Research (University Of London), 2023-08-01)Silicone is implanted widely in aesthetic and reconstructive surgery. The resultant immune response is poorly understood but implicated in two divergent capsular pathologies: fibrosis (capsular contracture, CC) and ... -
An in vivo investigation of dynamic contrast-enhanced ultrasound (DCE-US) imaging for the assessment of tumour response to radiotherapy
(Institute of Cancer Research (University Of London), 2022-08-22)Imaging biomarkers of early response to cancer therapy can facilitate more effective treatment adaptation and improve cancer management. These biomarkers can detect functional, structural or molecular tumour changes that ... -
Investigating determinants of sensitivity and resistance to T cell redirecting antibodies in colorectal cancer through patient derived organoid models
(Institute of Cancer Research (University Of London), 2023-06-12)Most colorectal cancers (CRCs) do not respond to treatment with immune-checkpoint-inhibitors due to modest mutation loads, low cytotoxic T cell infiltrates, and immunosuppressive microenvironments. The CEA-TCB bispecific ... -
Local therapeutic approaches for the management of recurrent gynaecological cancer
(Institute of Cancer Research (University Of London), 2022-02-28)Surgery, radiotherapy and chemotherapy combinations are used to treat recurrent gynaecological malignancy. Stereotactic body radiotherapy (SBRT) delivered to the involved surgical margin could improve clinical outcomes ... -
Markers predictive of response, resistance and relapse in colorectal cancer
(Institute of Cancer Research (University Of London), 2021-05-31)Response to neo-adjuvant chemo-radiotherapy (CRT) in locally advanced rectal cancer varies. Circulating tumour DNA (ctDNA) has emerged as a surrogate marker of the tumour genome. I hypothesised that ctDNA could be an early ... -
Measuring tumour evolution at the genetic and epigenetic level in individual patients from cancer genomic data
(Institute of Cancer Research (University Of London), 2020-01-31)High-throughput genomic data from cancers uncovered high intra and inter-tumour heterogeneity and subclonal architecture of cancer cell populations. If we consider cells as asexually reproducing individuals, we can apply ... -
Molecular mechanisms of PARP inhibitor sensitivity in primary triple negative breast cancer
(Institute of Cancer Research (University Of London), 2021-08-31)Triple negative breast cancer (TNBC) encompasses molecularly different subgroups, with a subgroup harbouring evidence of defective homologous recombination (HR) DNA repair. At present there are no biomarkers available in ... -
Reference dosimetry of MRI-guided radiotherapy machines
(Institute of Cancer Research (University Of London), 2021-09-30)A cutting-edge cancer treatment modality, that integrates MRI guidance and delivery of radiotherapy (MRIgRT), sets a new standard for personalised radiotherapy. There are, however, aspects around the accurate determination ... -
Roles of cancer associated fibroblasts in squamous cell carcinoma
(Institute of Cancer Research (University Of London), 2021-03-31)Cancer associated fibroblasts (CAFs) play a key role in the tumour microenvironment (TME) of squamous cell carcinoma. Influenced by cues from cancer cells, CAFS remodel the extracellular matrix and secrete cytokines and ... -
Structural investigation of NTC and of the coupling between splicing and polyadenylation
(Institute of Cancer Research (University Of London), 2022-10-31)This PhD thesis is composed of two parts. The first and foremost part describes the reconstitution, isolation and analysis of human complexes involved in the coupling between splicing and polyadenylation, with a special ...
