Search
Now showing items 21-26 of 26
The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C.
(CELL PRESS, 2016-12-15)
The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle. It catalyzes the production of the Mitotic Checkpoint Complex ...
Follow-up after treatment for head and neck cancer: United Kingdom National Multidisciplinary Guidelines.
(CAMBRIDGE UNIV PRESS, 2016-05-01)
This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. In the absence of high-level evidence base for follow-up practices, the duration and ...
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).
(Springer Science and Business Media LLC, 2016-08-17)
PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal ...
Study of Plasmodium falciparum DHHC palmitoyl transferases identifies a role for PfDHHC9 in gametocytogenesis.
(WILEY, 2016-11-01)
Palmitoylation is the post-translational reversible addition of the acyl moiety, palmitate, to cysteine residues of proteins and is involved in regulating protein trafficking, localization, stability and function. The ...
The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.
(NATURE PUBLISHING GROUP, 2016-04-11)
The Ku-binding motif (KBM) is a short peptide module first identified in APLF that we now show is also present in Werner syndrome protein (WRN) and in Modulator of retrovirus infection homologue (MRI). We also identify a ...
OpenMS: a flexible open-source software platform for mass spectrometry data analysis.
(NATURE PORTFOLIO, 2016-08-30)
High-resolution mass spectrometry (MS) has become an important tool in the life sciences, contributing to the diagnosis and understanding of human diseases, elucidating biomolecular structural information and characterizing ...