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Now showing items 51-56 of 56
Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System
(Elsevier BV, 2017-10-01)
The effects of segmentation algorithms on the measurement of 18F-FDG PET texture parameters in non-small cell lung cancer.
(Springer Science and Business Media LLC, 2017-12-01)
BACKGROUND: Measures of tumour heterogeneity derived from 18-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans are increasingly reported as potential biomarkers of non-small cell ...
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
(NATURE PUBLISHING GROUP, 2017-11-27)
Vps34 PI3K is thought to be the main producer of phosphatidylinositol-3-monophosphate, a lipid that controls intracellular vesicular trafficking. The organismal impact of systemic inhibition of Vps34 kinase activity is not ...
Splicing imbalances in basal-like breast cancer underpin perturbation of cell surface and oncogenic pathways and are associated with patients' survival.
(NATURE PORTFOLIO, 2017-01-06)
Despite advancements in the use of transcriptional information to understand and classify breast cancers, the contribution of splicing to the establishment and progression of these tumours has only recently starting to ...
Global, site-specific analysis of neuronal protein S-acylation.
(NATURE PORTFOLIO, 2017-07-05)
Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins ...
Signatures of positive selection reveal a universal role of chromatin modifiers as cancer driver genes.
(NATURE PORTFOLIO, 2017-10-13)
Tumors are composed of an evolving population of cells subjected to tissue-specific selection, which fuels tumor heterogeneity and ultimately complicates cancer driver gene identification. Here, we integrate cancer cell ...