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Review: The HSP90 molecular chaperone—an enigmatic ATPase
(Wiley, 2016-08-01)
<jats:title>ABSTRACT</jats:title><jats:p>The HSP90 molecular chaperone is involved in the activation and cellular stabilization of a range of ‘client’ proteins, of which oncogenic protein kinases and nuclear steroid hormone ...
PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).
(Springer Science and Business Media LLC, 2016-08-17)
PARP3 is a member of the ADP-ribosyl transferase superfamily that we show accelerates the repair of chromosomal DNA single-strand breaks in avian DT40 cells. Two-dimensional nuclear magnetic resonance experiments reveal ...
The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins.
(NATURE PUBLISHING GROUP, 2016-04-11)
The Ku-binding motif (KBM) is a short peptide module first identified in APLF that we now show is also present in Werner syndrome protein (WRN) and in Modulator of retrovirus infection homologue (MRI). We also identify a ...