Recent submissions
Now showing items 141-160 of 622
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What Resources do NHS Commissioning Organisations Use to Support Antimicrobial Stewardship in Primary Care in England?
(MDPI AG, 2020-04-02)Professional education and public engagement are fundamental components of any antimicrobial stewardship (AMS) strategy. The National Institute for Health and Care Excellence (NICE), Public Health England (PHE), Health ... -
Structure of the human RAD17-RFC clamp loader and 9-1-1 checkpoint clamp bound to a dsDNA-ssDNA junction.
(OXFORD UNIV PRESS, 2022-08-12)The RAD9-RAD1-HUS1 (9-1-1) clamp forms one half of the DNA damage checkpoint system that signals the presence of substantial regions of single-stranded DNA arising from replication fork collapse or resection of DNA double ... -
Mini-mesohepatectomy for tumours at the hepatocaval confluence: A cases series and review of the literature.
(ELSEVIER SCI LTD, 2022-06-30)Liver lesions located adjacent to the middle hepatic vein (MHV) at the hepatocaval confluence are rare. Mini-mesohepatectomy (MMH) allows resection of these lesions with preservation of liver parenchymal volume thus reducing ... -
Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment (ICON8): overall survival results from an open-label, randomised, controlled, phase 3 trial.
(ELSEVIER SCIENCE INC, 2022-07-01)BACKGROUND: Standard-of-care first-line chemotherapy for epithelial ovarian cancer is carboplatin and paclitaxel administered once every 3 weeks. The JGOG 3016 trial reported significant improvement in progression-free and ... -
100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care - Preliminary Report.
(MASSACHUSETTS MEDICAL SOC, 2021-11-11)BACKGROUND: The U.K. 100,000 Genomes Project is in the process of investigating the role of genome sequencing in patients with undiagnosed rare diseases after usual care and the alignment of this research with health care ... -
An environmentally friendly alternative to single-use plastics for radiotherapy bladder preparation.
(Elsevier BV, 2021-06-01)More than 60,000 plastic cups were used annually for bladder preparation in one radiotherapy centre. As an alternative, patients were provided with a specifically designed reusable water bottle, aiming to reduce waste and ... -
A Comparison of Real-World Treatment Patterns and Clinical Outcomes in Patients Receiving First-Line Therapy for Unresectable Advanced Gastric or Gastroesophageal Junction Cancer Versus Esophageal Adenocarcinomas.
(SPRINGER, 2020-11-26)INTRODUCTION: Management of locally advanced, unresectable, or metastatic (adv/met) esophageal adenocarcinoma (EAC) follows clinical guidance for gastric cancer (GC) and gastroesophageal junction cancer (GEJC). However, ... -
Appropriately smoothing prevalence data to inform estimates of growth rate and reproduction number.
(ELSEVIER, 2022-06-22)The time-varying reproduction number (Rt) can change rapidly over the course of a pandemic due to changing restrictions, behaviours, and levels of population immunity. Many methods exist that allow the estimation of Rt ... -
Impact of centralization of prostate cancer services on the choice of radical treatment.
(WILEY, 2022-06-20)OBJECTIVE: To assess the impact of centralization of prostate cancer surgery and radiotherapy services on the choice of prostate cancer treatment. PATIENTS AND METHODS: This national population-based study used linked ... -
Starting CT-guided robotic interventional oncology at a UK centre.
(BRITISH INST RADIOLOGY, 2022-06-01)OBJECTIVE: A commercially available CT-guided robot offers enhanced abilities in planning, targeting, and confirming accurate needle placement. In this short communication, we describe our first UK experience of robotic ... -
A Delphi consensus statement for digital surgery.
(NATURE PORTFOLIO, 2022-07-19)The use of digital technology is increasing rapidly across surgical specialities, yet there is no consensus for the term 'digital surgery'. This is critical as digital health technologies present technical, governance, and ... -
Association Study between Polymorphisms in DNA Methylation-Related Genes and Testicular Germ Cell Tumor Risk.
(AMER ASSOC CANCER RESEARCH, 2022-09-02)BACKGROUND: Testicular germ cell tumors (TGCT), histologically classified as seminomas and nonseminomas, are believed to arise from primordial gonocytes, with the maturation process blocked when they are subjected to DNA ... -
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
(NATURE PORTFOLIO, 2020-01-16)Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential ... -
"The Longest Way Round Is The Shortest Way Home": An Overhaul of Surgical Ward Rounds.
(SPRINGER, 2018-04-01)BACKGROUND: Ward rounds, a keystone of hospital surgical practice, have recently been under the spotlight. Poor-quality ward rounds can lead to a greater number of adverse events, thereby cascading to an increased financial ... -
Advanced practice roles of therapeutic radiographers/radiation therapists: A systematic literature review.
(ELSEVIER SCI LTD, 2022-08-01)INTRODUCTION: Advances in Radiotherapy (RT) technology and increase of complexity in cancer care have enabled the implementation of new treatment techniques. Subsequently, a greater level of autonomy, responsibility, and ... -
An in vivo investigation of dynamic contrast-enhanced ultrasound (DCE-US) imaging for the assessment of tumour response to radiotherapy
(Institute of Cancer Research (University Of London), 2022-08-22)Imaging biomarkers of early response to cancer therapy can facilitate more effective treatment adaptation and improve cancer management. These biomarkers can detect functional, structural or molecular tumour changes that ... -
Reclassification of clinically-detected sequence variants: Framework for genetic clinicians and clinical scientists by CanVIG-UK (Cancer Variant Interpretation Group UK).
(ELSEVIER SCIENCE INC, 2022-06-03)PURPOSE: Variant classifications may change over time, driven by emergence of fresh or contradictory evidence or evolution in weighing or combination of evidence items. For variant classifications above the actionability ... -
Does the addition of whole-body MRI to routine imaging influence real-world treatment decisions in metastatic breast cancer?
(BMC, 2022-06-07)BACKGROUND: The assessment of metastatic breast cancer (MBC) can be limited with routine imaging such as computed tomography (CT) especially in bone-only or bone-predominant disease. This analysis investigates the effects ... -
De-escalating Surgery Among Patients with HER2 + and Triple Negative Breast Cancer.
(SPRINGER, 2022-07-27)PURPOSE OF REVIEW: De-escalation of surgery has been central in the evolution of multidisciplinary management of breast cancer. Advances in oncology and increasing use of neoadjuvant chemotherapy (NACT) have opened ...