dc.contributor.author | Fehringer, G | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Pharoah, PD | |
dc.contributor.author | Eeles, RA | |
dc.contributor.author | Chatterjee, N | |
dc.contributor.author | Schumacher, FR | |
dc.contributor.author | Schildkraut, JM | |
dc.contributor.author | Lindström, S | |
dc.contributor.author | Brennan, P | |
dc.contributor.author | Bickeböller, H | |
dc.contributor.author | Houlston, RS | |
dc.contributor.author | Landi, MT | |
dc.contributor.author | Caporaso, N | |
dc.contributor.author | Risch, A | |
dc.contributor.author | Amin Al Olama, A | |
dc.contributor.author | Berndt, SI | |
dc.contributor.author | Giovannucci, EL | |
dc.contributor.author | Grönberg, H | |
dc.contributor.author | Kote-Jarai, Z | |
dc.contributor.author | Ma, J | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Stampfer, MJ | |
dc.contributor.author | Stevens, VL | |
dc.contributor.author | Wiklund, F | |
dc.contributor.author | Willett, WC | |
dc.contributor.author | Goode, EL | |
dc.contributor.author | Permuth, JB | |
dc.contributor.author | Risch, HA | |
dc.contributor.author | Reid, BM | |
dc.contributor.author | Bezieau, S | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Chan, AT | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Hudson, TJ | |
dc.contributor.author | Kocarnik, JK | |
dc.contributor.author | Newcomb, PA | |
dc.contributor.author | Schoen, RE | |
dc.contributor.author | Slattery, ML | |
dc.contributor.author | White, E | |
dc.contributor.author | Adank, MA | |
dc.contributor.author | Ahsan, H | |
dc.contributor.author | Aittomäki, K | |
dc.contributor.author | Baglietto, L | |
dc.contributor.author | Blomquist, C | |
dc.contributor.author | Canzian, F | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Dos-Santos-Silva, I | |
dc.contributor.author | Eliassen, AH | |
dc.contributor.author | Figueroa, JD | |
dc.contributor.author | Flesch-Janys, D | |
dc.contributor.author | Fletcher, O | |
dc.contributor.author | Garcia-Closas, M | |
dc.contributor.author | Gaudet, MM | |
dc.contributor.author | Johnson, N | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Hazra, A | |
dc.contributor.author | Hein, R | |
dc.contributor.author | Hofman, A | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Irwanto, A | |
dc.contributor.author | Johansson, M | |
dc.contributor.author | Kaaks, R | |
dc.contributor.author | Kibriya, MG | |
dc.contributor.author | Lichtner, P | |
dc.contributor.author | Liu, J | |
dc.contributor.author | Lund, E | |
dc.contributor.author | Makalic, E | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Müller-Myhsok, B | |
dc.contributor.author | Muranen, TA | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Peeters, PH | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Prentice, RL | |
dc.contributor.author | Rahman, N | |
dc.contributor.author | Sanchez, MJ | |
dc.contributor.author | Schmidt, DF | |
dc.contributor.author | Schmutzler, RK | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Tamimi, R | |
dc.contributor.author | Travis, RC | |
dc.contributor.author | Turnbull, C | |
dc.contributor.author | Uitterlinden, AG | |
dc.contributor.author | Wang, Z | |
dc.contributor.author | Whittemore, AS | |
dc.contributor.author | Yang, XR | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Buchanan, DD | |
dc.contributor.author | Casey, G | |
dc.contributor.author | Conti, DV | |
dc.contributor.author | Edlund, CK | |
dc.contributor.author | Gallinger, S | |
dc.contributor.author | Haile, RW | |
dc.contributor.author | Jenkins, M | |
dc.contributor.author | Le Marchand, L | |
dc.contributor.author | Li, L | |
dc.contributor.author | Lindor, NM | |
dc.contributor.author | Schmit, SL | |
dc.contributor.author | Thibodeau, SN | |
dc.contributor.author | Woods, MO | |
dc.contributor.author | Rafnar, T | |
dc.contributor.author | Gudmundsson, J | |
dc.contributor.author | Stacey, SN | |
dc.contributor.author | Stefansson, K | |
dc.contributor.author | Sulem, P | |
dc.contributor.author | Chen, YA | |
dc.contributor.author | Tyrer, JP | |
dc.contributor.author | Christiani, DC | |
dc.contributor.author | Wei, Y | |
dc.contributor.author | Shen, H | |
dc.contributor.author | Hu, Z | |
dc.contributor.author | Shu, X-O | |
dc.contributor.author | Shiraishi, K | |
dc.contributor.author | Takahashi, A | |
dc.contributor.author | Bossé, Y | |
dc.contributor.author | Obeidat, M | |
dc.contributor.author | Nickle, D | |
dc.contributor.author | Timens, W | |
dc.contributor.author | Freedman, ML | |
dc.contributor.author | Li, Q | |
dc.contributor.author | Seminara, D | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Gong, J | |
dc.contributor.author | Peters, U | |
dc.contributor.author | Gruber, SB | |
dc.contributor.author | Amos, CI | |
dc.contributor.author | Sellers, TA | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Henderson, BE | |
dc.contributor.author | Hung, RJ | |
dc.contributor.author | Ovarian Cancer Association Consortium (OCAC), | |
dc.contributor.author | PRACTICAL Consortium, | |
dc.contributor.author | Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), | |
dc.contributor.author | Colorectal Transdisciplinary (CORECT) Study, | |
dc.contributor.author | African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC), | |
dc.date.accessioned | 2016-09-30T15:58:14Z | |
dc.date.issued | 2016-09-01 | |
dc.identifier.citation | Cancer research, 2016, 76 (17), pp. 5103 - 5114 | |
dc.identifier.issn | 0008-5472 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/158 | |
dc.identifier.eissn | 1538-7445 | |
dc.identifier.doi | 10.1158/0008-5472.can-15-2980 | |
dc.description.abstract | Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR. | |
dc.format | Print-Electronic | |
dc.format.extent | 5103 - 5114 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | AMER ASSOC CANCER RESEARCH | |
dc.subject | Ovarian Cancer Association Consortium (OCAC) | |
dc.subject | PRACTICAL Consortium | |
dc.subject | Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) | |
dc.subject | Colorectal Transdisciplinary (CORECT) Study | |
dc.subject | African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC) | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Colorectal Neoplasms | |
dc.subject | Ovarian Neoplasms | |
dc.subject | Lung Neoplasms | |
dc.subject | Prostatic Neoplasms | |
dc.subject | Genotype | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Genome-Wide Association Study | |
dc.title | Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-04-05 | |
rioxxterms.versionofrecord | 10.1158/0008-5472.can-15-2980 | |
rioxxterms.licenseref.startdate | 2016-09 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Cancer research | |
pubs.issue | 17 | |
pubs.notes | 12 months | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 76 | |
pubs.embargo.terms | 12 months | |
icr.researchteam | Functional Genetic Epidemiology | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Genetic Susceptibility | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Eeles, Rosalind | |
dc.contributor.icrauthor | Houlston, Richard | |
dc.contributor.icrauthor | Kote-Jarai, Zsofia | |
dc.contributor.icrauthor | Fletcher, Olivia | |
dc.contributor.icrauthor | Garcia-Closas, Montserrat | |
dc.contributor.icrauthor | Turnbull, Clare | |