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dc.contributor.authorFehringer, Gen_US
dc.contributor.authorKraft, Pen_US
dc.contributor.authorPharoah, PDen_US
dc.contributor.authorEeles, RAen_US
dc.contributor.authorChatterjee, Nen_US
dc.contributor.authorSchumacher, FRen_US
dc.contributor.authorSchildkraut, JMen_US
dc.contributor.authorLindström, Sen_US
dc.contributor.authorBrennan, Pen_US
dc.contributor.authorBickeböller, Hen_US
dc.contributor.authorHoulston, RSen_US
dc.contributor.authorLandi, MTen_US
dc.contributor.authorCaporaso, Nen_US
dc.contributor.authorRisch, Aen_US
dc.contributor.authorAmin Al Olama, Aen_US
dc.contributor.authorBerndt, SIen_US
dc.contributor.authorGiovannucci, ELen_US
dc.contributor.authorGrönberg, Hen_US
dc.contributor.authorKote-Jarai, Zen_US
dc.contributor.authorMa, Jen_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorStampfer, MJen_US
dc.contributor.authorStevens, VLen_US
dc.contributor.authorWiklund, Fen_US
dc.contributor.authorWillett, WCen_US
dc.contributor.authorGoode, ELen_US
dc.contributor.authorPermuth, JBen_US
dc.contributor.authorRisch, HAen_US
dc.contributor.authorReid, BMen_US
dc.contributor.authorBezieau, Sen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorChan, ATen_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorHudson, TJen_US
dc.contributor.authorKocarnik, JKen_US
dc.contributor.authorNewcomb, PAen_US
dc.contributor.authorSchoen, REen_US
dc.contributor.authorSlattery, MLen_US
dc.contributor.authorWhite, Een_US
dc.contributor.authorAdank, MAen_US
dc.contributor.authorAhsan, Hen_US
dc.contributor.authorAittomäki, Ken_US
dc.contributor.authorBaglietto, Len_US
dc.contributor.authorBlomquist, Cen_US
dc.contributor.authorCanzian, Fen_US
dc.contributor.authorCzene, Ken_US
dc.contributor.authorDos-Santos-Silva, Ien_US
dc.contributor.authorEliassen, AHen_US
dc.contributor.authorFigueroa, JDen_US
dc.contributor.authorFlesch-Janys, Den_US
dc.contributor.authorFletcher, Oen_US
dc.contributor.authorGarcia-Closas, Men_US
dc.contributor.authorGaudet, MMen_US
dc.contributor.authorJohnson, Nen_US
dc.contributor.authorHall, Pen_US
dc.contributor.authorHazra, Aen_US
dc.contributor.authorHein, Ren_US
dc.contributor.authorHofman, Aen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorIrwanto, Aen_US
dc.contributor.authorJohansson, Men_US
dc.contributor.authorKaaks, Ren_US
dc.contributor.authorKibriya, MGen_US
dc.contributor.authorLichtner, Pen_US
dc.contributor.authorLiu, Jen_US
dc.contributor.authorLund, Een_US
dc.contributor.authorMakalic, Een_US
dc.contributor.authorMeindl, Aen_US
dc.contributor.authorMüller-Myhsok, Ben_US
dc.contributor.authorMuranen, TAen_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorPeeters, PHen_US
dc.contributor.authorPeto, Jen_US
dc.contributor.authorPrentice, RLen_US
dc.contributor.authorRahman, Nen_US
dc.contributor.authorSanchez, MJen_US
dc.contributor.authorSchmidt, DFen_US
dc.contributor.authorSchmutzler, RKen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorTamimi, Ren_US
dc.contributor.authorTravis, RCen_US
dc.contributor.authorTurnbull, Cen_US
dc.contributor.authorUitterlinden, AGen_US
dc.contributor.authorWang, Zen_US
dc.contributor.authorWhittemore, ASen_US
dc.contributor.authorYang, XRen_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorBuchanan, DDen_US
dc.contributor.authorCasey, Gen_US
dc.contributor.authorConti, DVen_US
dc.contributor.authorEdlund, CKen_US
dc.contributor.authorGallinger, Sen_US
dc.contributor.authorHaile, RWen_US
dc.contributor.authorJenkins, Men_US
dc.contributor.authorLe Marchand, Len_US
dc.contributor.authorLi, Len_US
dc.contributor.authorLindor, NMen_US
dc.contributor.authorSchmit, SLen_US
dc.contributor.authorThibodeau, SNen_US
dc.contributor.authorWoods, MOen_US
dc.contributor.authorRafnar, Ten_US
dc.contributor.authorGudmundsson, Jen_US
dc.contributor.authorStacey, SNen_US
dc.contributor.authorStefansson, Ken_US
dc.contributor.authorSulem, Pen_US
dc.contributor.authorChen, YAen_US
dc.contributor.authorTyrer, JPen_US
dc.contributor.authorChristiani, DCen_US
dc.contributor.authorWei, Yen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorHu, Zen_US
dc.contributor.authorShu, XOen_US
dc.contributor.authorShiraishi, Ken_US
dc.contributor.authorTakahashi, Aen_US
dc.contributor.authorBossé, Yen_US
dc.contributor.authorObeidat, Men_US
dc.contributor.authorNickle, Den_US
dc.contributor.authorTimens, Wen_US
dc.contributor.authorFreedman, MLen_US
dc.contributor.authorLi, Qen_US
dc.contributor.authorSeminara, Den_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorGong, Jen_US
dc.contributor.authorPeters, Uen_US
dc.contributor.authorGruber, SBen_US
dc.contributor.authorAmos, CIen_US
dc.contributor.authorSellers, TAen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorHunter, DJen_US
dc.contributor.authorHaiman, CAen_US
dc.contributor.authorHenderson, BEen_US
dc.contributor.authorHung, RJen_US
dc.date.accessioned2016-09-30T15:58:14Z
dc.date.issued2016-09en_US
dc.identifier.citationCancer research, 2016, 76 (17), pp. 5103 - 5114en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/158
dc.identifier.eissn1538-7445en_US
dc.identifier.doi10.1158/0008-5472.can-15-2980en_US
dc.description.abstractIdentifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Cancer Res; 76(17); 5103-14. ©2016 AACR.en_US
dc.formatPrint-Electronicen_US
dc.format.extent5103 - 5114en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectOvarian Cancer Association Consortium (OCAC)en_US
dc.subjectPRACTICAL Consortiumen_US
dc.subjectHereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)en_US
dc.subjectColorectal Transdisciplinary (CORECT) Studyen_US
dc.subjectAfrican American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC)en_US
dc.titleCross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-04-05en_US
rioxxterms.versionofrecord10.1158/0008-5472.can-15-2980en_US
rioxxterms.licenseref.startdate2016-09en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCancer researchen_US
pubs.issue17en_US
pubs.notes12 monthsen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Genetic Susceptibility
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.volume76en_US
pubs.embargo.terms12 monthsen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamGenetic Susceptibilityen_US
icr.researchteamMolecular & Population Geneticsen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorHoulston, Richarden_US
dc.contributor.icrauthorEeles, Rosalinden_US
dc.contributor.icrauthorKote-Jarai, Zsofiaen_US
dc.contributor.icrauthorRahman, Saberaen_US
dc.contributor.icrauthorFletcher, Oliviaen_US


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