dc.contributor.author | Girardi, F | |
dc.contributor.author | Barnes, DR | |
dc.contributor.author | Barrowdale, D | |
dc.contributor.author | Frost, D | |
dc.contributor.author | Brady, AF | |
dc.contributor.author | Miller, C | |
dc.contributor.author | Henderson, A | |
dc.contributor.author | Donaldson, A | |
dc.contributor.author | Murray, A | |
dc.contributor.author | Brewer, C | |
dc.contributor.author | Pottinger, C | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Eccles, D | |
dc.contributor.author | EMBRACE, | |
dc.contributor.author | Lalloo, F | |
dc.contributor.author | Gregory, H | |
dc.contributor.author | Cook, J | |
dc.contributor.author | Eason, J | |
dc.contributor.author | Adlard, J | |
dc.contributor.author | Barwell, J | |
dc.contributor.author | Ong, KR | |
dc.contributor.author | Walker, L | |
dc.contributor.author | Izatt, L | |
dc.contributor.author | Side, LE | |
dc.contributor.author | Kennedy, MJ | |
dc.contributor.author | Tischkowitz, M | |
dc.contributor.author | Rogers, MT | |
dc.contributor.author | Porteous, ME | |
dc.contributor.author | Morrison, PJ | |
dc.contributor.author | Eeles, R | |
dc.contributor.author | Davidson, R | |
dc.contributor.author | Snape, K | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Antoniou, AC | |
dc.date.accessioned | 2018-04-11T09:21:57Z | |
dc.date.issued | 2018-12-01 | |
dc.identifier.citation | Genetics in medicine : official journal of the American College of Medical Genetics, 2018, 20 (12), pp. 1575 - 1582 | |
dc.identifier.issn | 1098-3600 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1637 | |
dc.identifier.eissn | 1530-0366 | |
dc.identifier.doi | 10.1038/gim.2018.44 | |
dc.description.abstract | PURPOSE: BRCA1/BRCA2 predictive test negatives are proven noncarriers of a BRCA1/BRCA2 mutation that is carried by their relatives. The risk of developing breast cancer (BC) or epithelial ovarian cancer (EOC) in these women is uncertain. The study aimed to estimate risks of invasive BC and EOC in a large cohort of BRCA1/BRCA2 predictive test negatives. METHODS: We used cohort analysis to estimate incidences, cumulative risks, and standardized incidence ratios (SIRs). RESULTS: A total of 1,895 unaffected women were eligible for inclusion in the BC risk analysis and 1,736 in the EOC risk analysis. There were 23 incident invasive BCs and 2 EOCs. The cumulative risk of invasive BC was 9.4% (95% confidence interval (CI) 5.9-15%) by age 85 years and the corresponding risk of EOC was 0.6% (95% CI 0.2-2.6%). The SIR for invasive BC was 0.93 (95% CI 0.62-1.40) in the overall cohort, 0.85 (95% CI 0.48-1.50) in noncarriers from BRCA1 families, and 1.03 (95% CI 0.57-1.87) in noncarriers from BRCA2 families. The SIR for EOC was 0.79 (95% CI 0.20-3.17) in the overall cohort. CONCLUSION: Our results did not provide evidence for elevated risks of invasive BC or EOC in BRCA1/BRCA2 predictive test negatives. | |
dc.format | Print-Electronic | |
dc.format.extent | 1575 - 1582 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | EMBRACE | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Ovarian Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | BRCA1 Protein | |
dc.subject | BRCA2 Protein | |
dc.subject | Risk Assessment | |
dc.subject | Risk Factors | |
dc.subject | Germ-Line Mutation | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.title | Risks of breast or ovarian cancer in BRCA1 or BRCA2 predictive test negatives: findings from the EMBRACE study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-01-12 | |
rioxxterms.versionofrecord | 10.1038/gim.2018.44 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-sa/4.0 | |
rioxxterms.licenseref.startdate | 2018-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Genetics in medicine : official journal of the American College of Medical Genetics | |
pubs.issue | 12 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 20 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Eeles, Rosalind | |