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dc.contributor.authorConti, DV
dc.contributor.authorWang, K
dc.contributor.authorSheng, X
dc.contributor.authorBensen, JT
dc.contributor.authorHazelett, DJ
dc.contributor.authorCook, MB
dc.contributor.authorIngles, SA
dc.contributor.authorKittles, RA
dc.contributor.authorStrom, SS
dc.contributor.authorRybicki, BA
dc.contributor.authorNemesure, B
dc.contributor.authorIsaacs, WB
dc.contributor.authorStanford, JL
dc.contributor.authorZheng, W
dc.contributor.authorSanderson, M
dc.contributor.authorJohn, EM
dc.contributor.authorPark, JY
dc.contributor.authorXu, J
dc.contributor.authorStevens, VL
dc.contributor.authorBerndt, SI
dc.contributor.authorHuff, CD
dc.contributor.authorWang, Z
dc.contributor.authorYeboah, ED
dc.contributor.authorTettey, Y
dc.contributor.authorBiritwum, RB
dc.contributor.authorAdjei, AA
dc.contributor.authorTay, E
dc.contributor.authorTruelove, A
dc.contributor.authorNiwa, S
dc.contributor.authorSellers, TA
dc.contributor.authorYamoah, K
dc.contributor.authorMurphy, AB
dc.contributor.authorCrawford, DC
dc.contributor.authorGapstur, SM
dc.contributor.authorBush, WS
dc.contributor.authorAldrich, MC
dc.contributor.authorCussenot, O
dc.contributor.authorPetrovics, G
dc.contributor.authorCullen, J
dc.contributor.authorNeslund-Dudas, C
dc.contributor.authorStern, MC
dc.contributor.authorJarai, Z-K
dc.contributor.authorGovindasami, K
dc.contributor.authorChokkalingam, AP
dc.contributor.authorHsing, AW
dc.contributor.authorGoodman, PJ
dc.contributor.authorHoffmann, T
dc.contributor.authorDrake, BF
dc.contributor.authorHu, JJ
dc.contributor.authorClark, PE
dc.contributor.authorVan Den Eeden, SK
dc.contributor.authorBlanchet, P
dc.contributor.authorFowke, JH
dc.contributor.authorCasey, G
dc.contributor.authorHennis, AJM
dc.contributor.authorHan, Y
dc.contributor.authorLubwama, A
dc.contributor.authorThompson, IM
dc.contributor.authorLeach, R
dc.contributor.authorEaston, DF
dc.contributor.authorSchumacher, F
dc.contributor.authorVan den Berg, DJ
dc.contributor.authorGundell, SM
dc.contributor.authorStram, A
dc.contributor.authorWan, P
dc.contributor.authorXia, L
dc.contributor.authorPooler, LC
dc.contributor.authorMohler, JL
dc.contributor.authorFontham, ETH
dc.contributor.authorSmith, GJ
dc.contributor.authorTaylor, JA
dc.contributor.authorSrivastava, S
dc.contributor.authorEeles, RA
dc.contributor.authorCarpten, J
dc.contributor.authorKibel, AS
dc.contributor.authorMultigner, L
dc.contributor.authorParent, M-E
dc.contributor.authorMenegaux, F
dc.contributor.authorCancel-Tassin, G
dc.contributor.authorKlein, EA
dc.contributor.authorBrureau, L
dc.contributor.authorStram, DO
dc.contributor.authorWatya, S
dc.contributor.authorChanock, SJ
dc.contributor.authorWitte, JS
dc.contributor.authorBlot, WJ
dc.contributor.authorHenderson, BE
dc.contributor.authorHaiman, CA
dc.contributor.authorPRACTICAL/ELLIPSE Consortium,
dc.date.accessioned2018-04-11T13:22:42Z
dc.date.issued2017-08-01
dc.identifier.citationJournal of the National Cancer Institute, 2017, 109 (8)
dc.identifier.issn0027-8874
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1639
dc.identifier.eissn1460-2105
dc.identifier.doi10.1093/jnci/djx084
dc.description.abstractProstate cancer incidence is 1.6-fold higher in African Americans than in other populations. The risk factors that drive this disparity are unknown and potentially consist of social, environmental, and genetic influences. To investigate the genetic basis of prostate cancer in men of African ancestry, we performed a genome-wide association meta-analysis using two-sided statistical tests in 10 202 case subjects and 10 810 control subjects. We identified novel signals on chromosomes 13q34 and 22q12, with the risk-associated alleles found only in men of African ancestry (13q34: rs75823044, risk allele frequency = 2.2%, odds ratio [OR] = 1.55, 95% confidence interval [CI] = 1.37 to 1.76, P = 6.10 × 10-12; 22q12.1: rs78554043, risk allele frequency = 1.5%, OR = 1.62, 95% CI = 1.39 to 1.89, P = 7.50 × 10-10). At 13q34, the signal is located 5' of the gene IRS2 and 3' of a long noncoding RNA, while at 22q12 the candidate functional allele is a missense variant in the CHEK2 gene. These findings provide further support for the role of ancestry-specific germline variation in contributing to population differences in prostate cancer risk.
dc.formatPrint
dc.languageeng
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS INC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectPRACTICAL/ELLIPSE Consortium
dc.subjectChromosomes, Human, Pair 13
dc.subjectChromosomes, Human, Pair 22
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectCase-Control Studies
dc.subjectGene Frequency
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAfrican Continental Ancestry Group
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectInsulin Receptor Substrate Proteins
dc.subjectGenetic Loci
dc.subjectCheckpoint Kinase 2
dc.titleTwo Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.
dc.typeJournal Article
dcterms.dateAccepted2017-04-04
rioxxterms.versionofrecord10.1093/jnci/djx084
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2017-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfJournal of the National Cancer Institute
pubs.issue8
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume109
pubs.embargo.termsNot known
icr.researchteamOncogenetics
dc.contributor.icrauthorEeles, Rosalind


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