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Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI.

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Publication Date
2018-04
ICR Author
Robinson, Simon
Author
Walker-Samuel, S
Roberts, TA
Ramasawmy, R
Burrell, JS
Johnson, SP
Siow, BM
Richardson, S
Gonçalves, MR
Pendse, D
Robinson, SP
Pedley, RB
Lythgoe, MF
Type
Journal Article
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Abstract
Several distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel MRI technique named convection-MRI, which uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extravascular flow. Here, we report the results of experiments in flow phantoms, numerical simulations, and tumor xenograft models to investigate the technical feasibility of convection-MRI. We observed a significant correlation between estimates of effective fluid pressure from convection-MRI with gold-standard, invasive measurements of interstitial fluid pressure in mouse models of human colorectal carcinoma. Our results show how convection-MRI can provide insights into the growth and responsiveness to vascular-targeting therapy in colorectal cancers.Significance: A noninvasive method for measuring low-velocity fluid flow caused by raised fluid pressure can be used to assess changes caused by therapy. Cancer Res; 78(7); 1859-72. ©2018 AACR.
URL
https://repository.icr.ac.uk/handle/internal/1656
Collections
  • Radiotherapy and Imaging
Licenseref URL
http://www.rioxx.net/licenses/under-embargo-all-rights-reserved
Version of record
10.1158/0008-5472.can-17-1546
Subject
Cell Line, Tumor
Extracellular Fluid
Animals
Humans
Mice
Mice, Nude
Colorectal Neoplasms
Neovascularization, Pathologic
Magnetic Resonance Imaging
Drug Delivery Systems
Phantoms, Imaging
Models, Biological
Hydrodynamics
Research team
Pre-Clinical MRI
Language
eng
Date accepted
2018-01-05
License start date
2018-04
Citation
Cancer research, 2018, 78 (7), pp. 1859 - 1872

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