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dc.contributor.authorWedge, DC
dc.contributor.authorGundem, G
dc.contributor.authorMitchell, T
dc.contributor.authorWoodcock, DJ
dc.contributor.authorMartincorena, I
dc.contributor.authorGhori, M
dc.contributor.authorZamora, J
dc.contributor.authorButler, A
dc.contributor.authorWhitaker, H
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorAlexandrov, LB
dc.contributor.authorVan Loo, P
dc.contributor.authorMassie, CE
dc.contributor.authorDentro, S
dc.contributor.authorWarren, AY
dc.contributor.authorVerrill, C
dc.contributor.authorBerney, DM
dc.contributor.authorDennis, N
dc.contributor.authorMerson, S
dc.contributor.authorHawkins, S
dc.contributor.authorHowat, W
dc.contributor.authorLu, Y-J
dc.contributor.authorLambert, A
dc.contributor.authorKay, J
dc.contributor.authorKremeyer, B
dc.contributor.authorKaraszi, K
dc.contributor.authorLuxton, H
dc.contributor.authorCamacho, N
dc.contributor.authorMarsden, L
dc.contributor.authorEdwards, S
dc.contributor.authorMatthews, L
dc.contributor.authorBo, V
dc.contributor.authorLeongamornlert, D
dc.contributor.authorMcLaren, S
dc.contributor.authorNg, A
dc.contributor.authorYu, Y
dc.contributor.authorZhang, H
dc.contributor.authorDadaev, T
dc.contributor.authorThomas, S
dc.contributor.authorEaston, DF
dc.contributor.authorAhmed, M
dc.contributor.authorBancroft, E
dc.contributor.authorFisher, C
dc.contributor.authorLivni, N
dc.contributor.authorNicol, D
dc.contributor.authorTavaré, S
dc.contributor.authorGill, P
dc.contributor.authorGreenman, C
dc.contributor.authorKhoo, V
dc.contributor.authorVan As, N
dc.contributor.authorKumar, P
dc.contributor.authorOgden, C
dc.contributor.authorCahill, D
dc.contributor.authorThompson, A
dc.contributor.authorMayer, E
dc.contributor.authorRowe, E
dc.contributor.authorDudderidge, T
dc.contributor.authorGnanapragasam, V
dc.contributor.authorShah, NC
dc.contributor.authorRaine, K
dc.contributor.authorJones, D
dc.contributor.authorMenzies, A
dc.contributor.authorStebbings, L
dc.contributor.authorTeague, J
dc.contributor.authorHazell, S
dc.contributor.authorCorbishley, C
dc.contributor.authorCAMCAP Study Group
dc.contributor.authorde Bono, J
dc.contributor.authorAttard, G
dc.contributor.authorIsaacs, W
dc.contributor.authorVisakorpi, T
dc.contributor.authorFraser, M
dc.contributor.authorBoutros, PC
dc.contributor.authorBristow, RG
dc.contributor.authorWorkman, P
dc.contributor.authorSander, C
dc.contributor.authorTCGA Consortium
dc.contributor.authorHamdy, FC
dc.contributor.authorFutreal, A
dc.contributor.authorMcDermott, U
dc.contributor.authorAl-Lazikani, B
dc.contributor.authorLynch, AG
dc.contributor.authorBova, GS
dc.contributor.authorFoster, CS
dc.contributor.authorBrewer, DS
dc.contributor.authorNeal, DE
dc.contributor.authorCooper, CS
dc.contributor.authorEeles, RA
dc.date.accessioned2018-05-02T13:26:47Z
dc.date.issued2018-05
dc.identifier.citationNature genetics, 2018, 50 (5), pp. 682 - 692
dc.identifier.issn1061-4036
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1666
dc.identifier.eissn1546-1718
dc.identifier.doi10.1038/s41588-018-0086-z
dc.description.abstractProstate cancer represents a substantial clinical challenge because it is difficult to predict outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 primary and metastatic prostate cancer samples. From joint analysis of these cancers with those from previous studies (930 cancers in total), we found evidence for 22 previously unidentified putative driver genes harboring coding mutations, as well as evidence for NEAT1 and FOXA1 acting as drivers through noncoding mutations. Through the temporal dissection of aberrations, we identified driver mutations specifically associated with steps in the progression of prostate cancer, establishing, for example, loss of CHD1 and BRCA2 as early events in cancer development of ETS fusion-negative cancers. Computational chemogenomic (canSAR) analysis of prostate cancer mutations identified 11 targets of approved drugs, 7 targets of investigational drugs, and 62 targets of compounds that may be active and should be considered candidates for future clinical trials.
dc.formatPrint-Electronic
dc.format.extent682 - 692
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectCAMCAP Study Group
dc.subjectTCGA Consortium
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectDisease Progression
dc.subjectBRCA2 Protein
dc.subjectMutation
dc.subjectOncogenes
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectHepatocyte Nuclear Factor 3-alpha
dc.subjectHigh-Throughput Nucleotide Sequencing
dc.titleSequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.
dc.typeJournal Article
dcterms.dateAccepted2018-02-22
rioxxterms.versionofrecord10.1038/s41588-018-0086-z
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2018-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature genetics
pubs.issue5
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Computational Biology and Chemogenomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Stereotactic and Precision Body Radiotherapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Stereotactic and Precision Body Radiotherapy/Stereotactic and Precision Body Radiotherapy (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Computational Biology and Chemogenomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Stereotactic and Precision Body Radiotherapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Stereotactic and Precision Body Radiotherapy/Stereotactic and Precision Body Radiotherapy (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume50
pubs.embargo.termsNot known
icr.researchteamComputational Biology and Chemogenomicsen_US
icr.researchteamProstate Cancer Targeted Therapy Groupen_US
icr.researchteamOncogeneticsen_US
icr.researchteamStereotactic and Precision Body Radiotherapyen_US
dc.contributor.icrauthorAl-Lazikani, Bissanen
dc.contributor.icrauthorAhmed, Mahbublen
dc.contributor.icrauthorThwaites, Alisonen
dc.contributor.icrauthorEeles, Rosalinden
dc.contributor.icrauthorFisher, Cyrilen
dc.contributor.icrauthorvan As, Nicken
dc.contributor.icrauthorWorkman, Paulen
dc.contributor.icrauthorKote-Jarai, Zsofiaen
dc.contributor.icrauthorDe Bono, Johannen
dc.contributor.icrauthorKumar, Pardeepen


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