dc.contributor.author | Claus, EB | |
dc.contributor.author | Cornish, AJ | |
dc.contributor.author | Broderick, P | |
dc.contributor.author | Schildkraut, JM | |
dc.contributor.author | Dobbins, SE | |
dc.contributor.author | Holroyd, A | |
dc.contributor.author | Calvocoressi, L | |
dc.contributor.author | Lu, L | |
dc.contributor.author | Hansen, HM | |
dc.contributor.author | Smirnov, I | |
dc.contributor.author | Walsh, KM | |
dc.contributor.author | Schramm, J | |
dc.contributor.author | Hoffmann, P | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | Jöckel, K-H | |
dc.contributor.author | Swerdlow, A | |
dc.contributor.author | Larsen, SB | |
dc.contributor.author | Johansen, C | |
dc.contributor.author | Simon, M | |
dc.contributor.author | Bondy, M | |
dc.contributor.author | Wrensch, M | |
dc.contributor.author | Houlston, RS | |
dc.contributor.author | Wiemels, JL | |
dc.date.accessioned | 2018-05-17T15:05:30Z | |
dc.date.issued | 2018-10-09 | |
dc.identifier.citation | Neuro-oncology, 2018, 20 (11), pp. 1485 - 1493 | |
dc.identifier.issn | 1522-8517 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1675 | |
dc.identifier.eissn | 1523-5866 | |
dc.identifier.doi | 10.1093/neuonc/noy077 | |
dc.description.abstract | BACKGROUND: Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31. METHODS: To identify a susceptibility locus for meningioma, we conducted a meta-analysis of 2 GWAS, imputed using a merged reference panel from the 1000 Genomes Project and UK10K data, with validation in 2 independent sample series totaling 2138 cases and 12081 controls. RESULTS: We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges. CONCLUSIONS: This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma. | |
dc.format | Print | |
dc.format.extent | 1485 - 1493 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | OXFORD UNIV PRESS INC | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Chromosomes, Human, Pair 11 | |
dc.subject | Humans | |
dc.subject | Meningioma | |
dc.subject | Meningeal Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Prognosis | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Follow-Up Studies | |
dc.subject | Genotype | |
dc.subject | Linkage Disequilibrium | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Young Adult | |
dc.subject | Genetic Loci | |
dc.subject | Biomarkers, Tumor | |
dc.title | Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-05-08 | |
rioxxterms.versionofrecord | 10.1093/neuonc/noy077 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
rioxxterms.licenseref.startdate | 2018-10 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Neuro-oncology | |
pubs.issue | 11 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.publication-status | Published | |
pubs.volume | 20 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Cancer Genomics | |
dc.contributor.icrauthor | Cornish, Alexander | |
dc.contributor.icrauthor | Broderick, Peter | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Houlston, Richard | |