Five endometrial cancer risk loci identified through genome-wide association analysis.

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Publication Date
2016-06Author
Cheng, TH
Thompson, DJ
O'Mara, TA
Painter, JN
Glubb, DM
Flach, S
Lewis, A
French, JD
Freeman-Mills, L
Church, D
Gorman, M
Martin, L
National Study of Endometrial Cancer Genetics Group (NSECG)
Hodgson, S
Webb, PM
Australian National Endometrial Cancer Study Group (ANECS)
Attia, J
Holliday, EG
McEvoy, M
Scott, RJ
Henders, AK
Martin, NG
Montgomery, GW
Nyholt, DR
Ahmed, S
Healey, CS
Shah, M
Dennis, J
Fasching, PA
Beckmann, MW
Hein, A
Ekici, AB
Hall, P
Czene, K
Darabi, H
Li, J
Dörk, T
Dürst, M
Hillemanns, P
Runnebaum, I
Amant, F
Schrauwen, S
Zhao, H
Lambrechts, D
Depreeuw, J
Dowdy, SC
Goode, EL
Fridley, BL
Winham, SJ
Njølstad, TS
Salvesen, HB
Trovik, J
Werner, HM
Ashton, K
Otton, G
Proietto, T
Liu, T
Mints, M
Tham, E
RENDOCAS
Consortium, C
Jun Li, M
Yip, SH
Wang, J
Bolla, MK
Michailidou, K
Wang, Q
Tyrer, JP
Dunlop, M
Houlston, R
Palles, C
Hopper, JL
AOCS Group
Peto, J
Swerdlow, AJ
Burwinkel, B
Brenner, H
Meindl, A
Brauch, H
Lindblom, A
Chang-Claude, J
Couch, FJ
Giles, GG
Kristensen, VN
Cox, A
Cunningham, JM
Pharoah, PDP
Dunning, AM
Edwards, SL
Easton, DF
Tomlinson, I
Spurdle, AB
Type
Journal Article
Metadata
Show full item recordAbstract
We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation and meta-analysis identified five new risk loci of genome-wide significance at likely regulatory regions on chromosomes 13q22.1 (rs11841589, near KLF5), 6q22.31 (rs13328298, in LOC643623 and near HEY2 and NCOA7), 8q24.21 (rs4733613, telomeric to MYC), 15q15.1 (rs937213, in EIF2AK4, near BMF) and 14q32.33 (rs2498796, in AKT1, near SIVA1). We also found a second independent 8q24.21 signal (rs17232730). Functional studies of the 13q22.1 locus showed that rs9600103 (pairwise r(2) = 0.98 with rs11841589) is located in a region of active chromatin that interacts with the KLF5 promoter region. The rs9600103[T] allele that is protective in endometrial cancer suppressed gene expression in vitro, suggesting that regulation of the expression of KLF5, a gene linked to uterine development, is implicated in tumorigenesis. These findings provide enhanced insight into the genetic and biological basis of endometrial cancer.
Open access location
http://www.nature.com/ng/journal/v48/n6/pdf/ng.3562.pdfCollections
Version of record
Subject
National Study of Endometrial Cancer Genetics Group (NSECG)
Australian National Endometrial Cancer Study Group (ANECS)
RENDOCAS
AOCS Group
Chromosomes, Human, Pair 8
Humans
Endometrial Neoplasms
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Female
Promoter Regions, Genetic
Genome-Wide Association Study
Research team
Aetiological Epidemiology
Cancer Genomics
Language
eng
Date accepted
2016-04-08
License start date
2016-06
Citation
Nature genetics, 2016, 48 (6), pp. 667 - 674
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