dc.contributor.author | Montes, M | |
dc.contributor.author | Becerra, S | |
dc.contributor.author | Sánchez-Álvarez, M | |
dc.contributor.author | Suñé, C | |
dc.date.accessioned | 2018-06-06T09:40:49Z | |
dc.date.issued | 2012-06-01 | |
dc.identifier | http://publications.icr.ac.uk/11763/ | |
dc.identifier.citation | 2012, pp. 104 - 117 | |
dc.identifier.issn | 0378-1119 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1735 | |
dc.description.abstract | The tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing is a key mechanism to increase the number and complexity of proteins encoded by the genome. Evidence gathered in recent years has established that transcription and splicing are physically and functionally coupled and that this coupling may be an essential aspect of the regulation of splicing and alternative splicing. Recent advances in our understanding of transcription and of splicing regulation have uncovered the multiple interactions between components from both types of machinery. These interactions help to explain the functional coupling of RNAPII transcription and pre-mRNA alternative splicing for efficient and regulated gene expression at the molecular level. Recent technological advances, in addition to novel cell and molecular biology approaches, have led to the development of new tools for addressing mechanistic questions to achieve an integrated and global understanding of the functional coupling of RNAPII transcription and pre-mRNA alternative splicing. Here, we review major milestones and insights into RNA polymerase II transcription and pre-mRNA alternative splicing as well as new concepts and challenges that have arisen from multiple genome-wide approaches and analyses at the single-cell resolution. (C) 2012 Elsevier B.V. All rights reserved. | |
dc.format.extent | 104 - 117 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Elsevier BV | |
dc.subject | Processing of RNA Co-transcriptional splicing RNA polymerase II rna-polymerase-ii pre-messenger-rna carboxyl-terminal domain huntingtons-disease pathogenesis pol-ii ww domain in-vivo dna-damage drosophila-melanogaster exon definition | |
dc.title | Functional coupling of transcription and splicing | |
dc.type | Journal Article | |
rioxxterms.licenseref.startdate | 2012-06 | |
rioxxterms.type | Journal Article/Review | |
pubs.notes | ISI Document Delivery No.: 951OV Times Cited: 0 Cited Reference Count: 216 Montes, Marta Becerra, Soraya Sanchez-Alvarez, Miguel Sune, Carlos Spanish Ministry of Science and Innovation[BFU2008-01599, BFU2011-24577]; Foundation for Research and Prevention of AIDS in Spain[FIPSE-36768/08]; Andalusian Government[CVI-4626/2009]; European Region Development Fund, ERDF (FEDER); Spanish Ministry of Education (FPU) This work was supported by grants from the Spanish Ministry of Science and Innovation (BFU2008-01599 and BFU2011-24577), by the Foundation for Research and Prevention of AIDS in Spain (FIPSE-36768/08), and by the Andalusian Government (Excellence Project CVI-4626/2009) to C.S. Support from the European Region Development Fund, ERDF (FEDER) is also acknowledged. M.M. was supported by a fellowship from the Spanish Ministry of Education (FPU program). Elsevier science bv Amsterdam | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Dynamical Cell Systems | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Dynamical Cell Systems | |
pubs.embargo.terms | Not known | |
icr.researchteam | Dynamical Cell Systems | |
dc.contributor.icrauthor | Sanchez Alvarez, Miguel | |