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dc.identifier.citation2012, pp. 104 - 117en_US
dc.description.abstractThe tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing is a key mechanism to increase the number and complexity of proteins encoded by the genome. Evidence gathered in recent years has established that transcription and splicing are physically and functionally coupled and that this coupling may be an essential aspect of the regulation of splicing and alternative splicing. Recent advances in our understanding of transcription and of splicing regulation have uncovered the multiple interactions between components from both types of machinery. These interactions help to explain the functional coupling of RNAPII transcription and pre-mRNA alternative splicing for efficient and regulated gene expression at the molecular level. Recent technological advances, in addition to novel cell and molecular biology approaches, have led to the development of new tools for addressing mechanistic questions to achieve an integrated and global understanding of the functional coupling of RNAPII transcription and pre-mRNA alternative splicing. Here, we review major milestones and insights into RNA polymerase II transcription and pre-mRNA alternative splicing as well as new concepts and challenges that have arisen from multiple genome-wide approaches and analyses at the single-cell resolution. (C) 2012 Elsevier B.V. All rights reserved.en_US
dc.format.extent104 - 117en_US
dc.subjectProcessing of RNA Co-transcriptional splicing RNA polymerase II rna-polymerase-ii pre-messenger-rna carboxyl-terminal domain huntingtons-disease pathogenesis pol-ii ww domain in-vivo dna-damage drosophila-melanogaster exon definitionen_US
dc.titleFunctional coupling of transcription and splicingen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
pubs.notesISI Document Delivery No.: 951OV Times Cited: 0 Cited Reference Count: 216 Montes, Marta Becerra, Soraya Sanchez-Alvarez, Miguel Sune, Carlos Spanish Ministry of Science and Innovation[BFU2008-01599, BFU2011-24577]; Foundation for Research and Prevention of AIDS in Spain[FIPSE-36768/08]; Andalusian Government[CVI-4626/2009]; European Region Development Fund, ERDF (FEDER); Spanish Ministry of Education (FPU) This work was supported by grants from the Spanish Ministry of Science and Innovation (BFU2008-01599 and BFU2011-24577), by the Foundation for Research and Prevention of AIDS in Spain (FIPSE-36768/08), and by the Andalusian Government (Excellence Project CVI-4626/2009) to C.S. Support from the European Region Development Fund, ERDF (FEDER) is also acknowledged. M.M. was supported by a fellowship from the Spanish Ministry of Education (FPU program). Elsevier science bv Amsterdamen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Dynamical Cell Systems
pubs.embargo.termsNot knownen_US
icr.researchteamDynamical Cell Systemsen_US
dc.contributor.icrauthorSanchez Alvarez, Miguelen_US

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