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Functional coupling of transcription and splicing

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Date
2012-06
ICR Author
Sanchez Alvarez, Miguel
Type
Journal Article
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Abstract
The tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing is a key mechanism to increase the number and complexity of proteins encoded by the genome. Evidence gathered in recent years has established that transcription and splicing are physically and functionally coupled and that this coupling may be an essential aspect of the regulation of splicing and alternative splicing. Recent advances in our understanding of transcription and of splicing regulation have uncovered the multiple interactions between components from both types of machinery. These interactions help to explain the functional coupling of RNAPII transcription and pre-mRNA alternative splicing for efficient and regulated gene expression at the molecular level. Recent technological advances, in addition to novel cell and molecular biology approaches, have led to the development of new tools for addressing mechanistic questions to achieve an integrated and global understanding of the functional coupling of RNAPII transcription and pre-mRNA alternative splicing. Here, we review major milestones and insights into RNA polymerase II transcription and pre-mRNA alternative splicing as well as new concepts and challenges that have arisen from multiple genome-wide approaches and analyses at the single-cell resolution. (C) 2012 Elsevier B.V. All rights reserved.
URI
https://repository.icr.ac.uk/handle/internal/1735
Collections
  • Cancer Biology
Subject
Processing of RNA Co-transcriptional splicing RNA polymerase II rna-polymerase-ii pre-messenger-rna carboxyl-terminal domain huntingtons-disease pathogenesis pol-ii ww domain in-vivo dna-damage drosophila-melanogaster exon definition
Research team
Dynamical Cell Systems
Language
eng
License start date
2012-06
Citation
2012, pp. 104 - 117

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