dc.contributor.author | Wang, Y | |
dc.contributor.author | McKay, JD | |
dc.contributor.author | Rafnar, T | |
dc.contributor.author | Wang, Z | |
dc.contributor.author | Timofeeva, MN | |
dc.contributor.author | Broderick, P | |
dc.contributor.author | Zong, X | |
dc.contributor.author | Laplana, M | |
dc.contributor.author | Wei, Y | |
dc.contributor.author | Han, Y | |
dc.contributor.author | Lloyd, A | |
dc.contributor.author | Delahaye-Sourdeix, M | |
dc.contributor.author | Chubb, D | |
dc.contributor.author | Gaborieau, V | |
dc.contributor.author | Wheeler, W | |
dc.contributor.author | Chatterjee, N | |
dc.contributor.author | Thorleifsson, G | |
dc.contributor.author | Sulem, P | |
dc.contributor.author | Liu, G | |
dc.contributor.author | Kaaks, R | |
dc.contributor.author | Henrion, M | |
dc.contributor.author | Kinnersley, B | |
dc.contributor.author | Vallée, M | |
dc.contributor.author | LeCalvez-Kelm, F | |
dc.contributor.author | Stevens, VL | |
dc.contributor.author | Gapstur, SM | |
dc.contributor.author | Chen, WV | |
dc.contributor.author | Zaridze, D | |
dc.contributor.author | Szeszenia-Dabrowska, N | |
dc.contributor.author | Lissowska, J | |
dc.contributor.author | Rudnai, P | |
dc.contributor.author | Fabianova, E | |
dc.contributor.author | Mates, D | |
dc.contributor.author | Bencko, V | |
dc.contributor.author | Foretova, L | |
dc.contributor.author | Janout, V | |
dc.contributor.author | Krokan, HE | |
dc.contributor.author | Gabrielsen, ME | |
dc.contributor.author | Skorpen, F | |
dc.contributor.author | Vatten, L | |
dc.contributor.author | Njølstad, I | |
dc.contributor.author | Chen, C | |
dc.contributor.author | Goodman, G | |
dc.contributor.author | Benhamou, S | |
dc.contributor.author | Vooder, T | |
dc.contributor.author | Välk, K | |
dc.contributor.author | Nelis, M | |
dc.contributor.author | Metspalu, A | |
dc.contributor.author | Lener, M | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Johansson, M | |
dc.contributor.author | Vineis, P | |
dc.contributor.author | Agudo, A | |
dc.contributor.author | Clavel-Chapelon, F | |
dc.contributor.author | Bueno-de-Mesquita, HB | |
dc.contributor.author | Trichopoulos, D | |
dc.contributor.author | Khaw, K-T | |
dc.contributor.author | Johansson, M | |
dc.contributor.author | Weiderpass, E | |
dc.contributor.author | Tjønneland, A | |
dc.contributor.author | Riboli, E | |
dc.contributor.author | Lathrop, M | |
dc.contributor.author | Scelo, G | |
dc.contributor.author | Albanes, D | |
dc.contributor.author | Caporaso, NE | |
dc.contributor.author | Ye, Y | |
dc.contributor.author | Gu, J | |
dc.contributor.author | Wu, X | |
dc.contributor.author | Spitz, MR | |
dc.contributor.author | Dienemann, H | |
dc.contributor.author | Rosenberger, A | |
dc.contributor.author | Su, L | |
dc.contributor.author | Matakidou, A | |
dc.contributor.author | Eisen, T | |
dc.contributor.author | Stefansson, K | |
dc.contributor.author | Risch, A | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Christiani, DC | |
dc.contributor.author | Hung, RJ | |
dc.contributor.author | Brennan, P | |
dc.contributor.author | Landi, MT | |
dc.contributor.author | Houlston, RS | |
dc.contributor.author | Amos, CI | |
dc.date.accessioned | 2018-06-13T09:37:08Z | |
dc.date.issued | 2014-09-11 | |
dc.identifier.citation | Nature genetics, 2014, 46 (7), pp. 736 - 741 | |
dc.identifier.issn | 1061-4036 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1849 | |
dc.identifier.eissn | 1546-1718 | |
dc.identifier.doi | 10.1038/ng.3002 | |
dc.description.abstract | We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and 38,295 controls for follow-up. We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)). We also showed an association between common variation at 3q28 (TP63, rs13314271, OR = 1.13, P = 7.22 × 10(-10)) and lung adenocarcinoma that had been previously reported only in Asians. These findings provide further evidence for inherited genetic susceptibility to lung cancer and its biological basis. Additionally, our analysis demonstrates that imputation can identify rare disease-causing variants with substantive effects on cancer risk from preexisting genome-wide association study data. | |
dc.format | Print-Electronic | |
dc.format.extent | 736 - 741 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
dc.subject | Humans | |
dc.subject | Adenocarcinoma | |
dc.subject | Carcinoma, Squamous Cell | |
dc.subject | Lung Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | BRCA2 Protein | |
dc.subject | Prognosis | |
dc.subject | Risk Factors | |
dc.subject | Case-Control Studies | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Meta-Analysis as Topic | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Checkpoint Kinase 2 | |
dc.title | Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2014-05-08 | |
rioxxterms.versionofrecord | 10.1038/ng.3002 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2014-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature genetics | |
pubs.issue | 7 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.publication-status | Published | |
pubs.volume | 46 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Molecular & Population Genetics | |
dc.contributor.icrauthor | Wang, Yufei | |
dc.contributor.icrauthor | Chubb, Daniel | |
dc.contributor.icrauthor | Kinnersley, Benjamin | |
dc.contributor.icrauthor | Houlston, Richard | |